GR35517B - METHOD FOR THE MANUFACTURE OF MAIN PRODUCTS OF DIVENZOXEPINE. - Google Patents
METHOD FOR THE MANUFACTURE OF MAIN PRODUCTS OF DIVENZOXEPINE.Info
- Publication number
- GR35517B GR35517B GR670135517A GR670135517A GR35517B GR 35517 B GR35517 B GR 35517B GR 670135517 A GR670135517 A GR 670135517A GR 670135517 A GR670135517 A GR 670135517A GR 35517 B GR35517 B GR 35517B
- Authority
- GR
- Greece
- Prior art keywords
- alkyl
- alkoxy
- general formula
- acyloxyalkyl
- salts
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
έθοδος δια την παρασκευήν βασικών παραγώγων της διβενζοξεπίνης του γενικού τύπου Ι: [*] εις τον οποίον Χ σημαίνει οξυμεθυλενομάδα, R1 σημαίνει υδρογόνον, εν άτομον αλογόνου, μίαν κατωτέραν αλκυλο-, αλκόξυ-, τριφθοριομέθυλο-, ή μίαν αλκυλομέρκαπτομάδα, R2 και R3 σημαίνουν υδρογόνον, μίαν άλκυλο-αλκένυλο-, υδρόξυαλκυλο-, αλκόξυάλκυλο- ή ακυλοξυαλκυλομάδα, οπότε R2 και R3, επίσης επίσης και ομού, δύνανται να σχηματίσουν ένα πυρρολίδινο- πιπερίδινο-, μορφόλινο- και πιπεραζινο-δακτύλιον, όστις ενδεχομένως είναι υποκατεστημένος δι' αλκυλο-, αλκόξυ-,αλκόξυαλκυλο-, ακυλοξυαλκυλο-, αρυλο ή αραλκυλομάδων, ως και των αλάτων των παραγώγων τούτων μετά φαρμακολογικώς επιτρεπτών οξέων, χαρακτηριζομένη εκτου ότι, φέρομεν εις αντίδρασιν ουσίας του γενικού τύπου ΙΙ: [*] εις τον οποίον R1 και Χ έχουν την ανωτέρω δοθείσαν σημασίαν, και το R4 σημαίνει εν άτομον χλωρίου, ή εν άτομον βρωμίου, ή το υπόλοιποντου τοσυλοξέος, μετ' αμινών του γενικού τύπου ΙΙΙ: [*] εις τον οποίον R2 και R3 έχουν την ανωτέρω αναφερθείσαν σημασίαν, και τας ούτω λαμβανομένας ενώσεις μετατρέπομεν, ενδεχομένως, κατά γνωστόν καθ'εαυτόν τρόπον, εις τα άλατα αυτών μετά φαρμακολογικώς επιτρεπτών οξέων. Method for the preparation of basic dibenzoxepine derivatives of general formula I: [*] wherein X means oxymethylene group, R 1 means hydrogen, in a halogen atom, a lower alkyl-, alkoxy-, trifluoromethyl-, or an alkylmercapto group, R 2 and R 3 mean hydrogen, an alkyl-alkyloxy-alkyl, alkoxy, wherein R 2 and R 3, as well as together, may form a pyrrolidine-piperidine-, morpholine- and piperazino-ring, which may be substituted by alkyl-, alkoxy-, alkoxyalkyl-, acyloxyalkyl, acyloxyalkyl or as well as the salts of these derivatives with pharmacologically acceptable acids, characterized in that they are reacting with a substance of general formula II: [*] wherein R 1 and X have the above meaning, and R 4 means in the chlorine atom, or in the bromine atom, or the residual tosyloic acid, with amines of general formula III: [*] wherein R2 and R3 have the above-mentioned significance, and the compounds thus obtained are optionally converted, in a manner known per se, to their salts with pharmacologically acceptable acids.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR670135517A GR35517B (en) | 1967-04-27 | 1967-04-27 | METHOD FOR THE MANUFACTURE OF MAIN PRODUCTS OF DIVENZOXEPINE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR670135517A GR35517B (en) | 1967-04-27 | 1967-04-27 | METHOD FOR THE MANUFACTURE OF MAIN PRODUCTS OF DIVENZOXEPINE. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR35517B true GR35517B (en) | 1968-09-28 |
Family
ID=36887973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR670135517A GR35517B (en) | 1967-04-27 | 1967-04-27 | METHOD FOR THE MANUFACTURE OF MAIN PRODUCTS OF DIVENZOXEPINE. |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR35517B (en) |
-
1967
- 1967-04-27 GR GR670135517A patent/GR35517B/en unknown
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