GR3037074T3 - Protein kinase c inhibitors - Google Patents

Protein kinase c inhibitors

Info

Publication number
GR3037074T3
GR3037074T3 GR20010401946T GR20010401946T GR3037074T3 GR 3037074 T3 GR3037074 T3 GR 3037074T3 GR 20010401946 T GR20010401946 T GR 20010401946T GR 20010401946 T GR20010401946 T GR 20010401946T GR 3037074 T3 GR3037074 T3 GR 3037074T3
Authority
GR
Greece
Prior art keywords
beta
protein kinase
inhibitors
isozyme
present
Prior art date
Application number
GR20010401946T
Other languages
English (en)
Inventor
James Ronald Gillig
Michael Robert Jirousek
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/263,912 external-priority patent/US5481003A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of GR3037074T3 publication Critical patent/GR3037074T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR20010401946T 1994-06-22 2001-10-30 Protein kinase c inhibitors GR3037074T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/263,912 US5481003A (en) 1994-06-22 1994-06-22 Protein kinase C inhibitors
US08/404,218 US5491242A (en) 1994-06-22 1995-03-15 Protein kinase C inhibitors
PCT/US1995/007791 WO1995035294A1 (en) 1994-06-22 1995-06-19 Protein kinase c inhibitors

Publications (1)

Publication Number Publication Date
GR3037074T3 true GR3037074T3 (en) 2002-01-31

Family

ID=26950130

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010401946T GR3037074T3 (en) 1994-06-22 2001-10-30 Protein kinase c inhibitors

Country Status (11)

Country Link
US (1) US5491242A (el)
EP (1) EP0766682B1 (el)
JP (1) JPH10502910A (el)
AT (1) ATE203991T1 (el)
AU (1) AU2866995A (el)
DE (1) DE69522109T2 (el)
DK (1) DK0766682T3 (el)
ES (1) ES2159318T3 (el)
GR (1) GR3037074T3 (el)
PT (1) PT766682E (el)
WO (1) WO1995035294A1 (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919946A (en) * 1996-03-20 1999-07-06 Eli Lilly And Company Synthesis of indolylmaleimides
UA54427C2 (uk) * 1996-05-01 2003-03-17 Елі Ліллі Енд Компані Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
NZ332645A (en) 1996-05-01 2000-07-28 Lilly Co Eli use of a bis-indolylmaleimide derivative for treating VEGF related diseases
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
US6093709A (en) * 1996-08-22 2000-07-25 Eli Lilly And Company Therapeutic treatment for sexual dysfunctions
US6107327A (en) * 1996-08-30 2000-08-22 Eli Lilly And Company Therapeutic treatment for HIV infection
US5962446A (en) * 1996-08-30 1999-10-05 Eli Lilly And Company Therapetutic treatment for human T cell lymphotrophic virus type 1 infection
US6093740A (en) * 1997-04-30 2000-07-25 Eli Lilly And Company Therapeutic treatment for skin disorders
CA2227688C (en) 1998-01-16 2007-07-31 James W. Critchfield Methods and compositions for inhibition of viral replication
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases
US6291446B1 (en) 1998-03-05 2001-09-18 Eli Lilly And Company Therapeutic treatment for cytomegalovirus infection
US6225301B1 (en) 1998-03-05 2001-05-01 Eli Lilly And Company Therapeutic treatment for renal dysfunction
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6492406B1 (en) * 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6284783B1 (en) 1999-06-09 2001-09-04 The Uab Research Foundation Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
DE10244453A1 (de) 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US8592368B2 (en) 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0513881D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0329667D0 (en) 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
WO2006108270A1 (en) * 2005-04-11 2006-10-19 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
WO2007033374A2 (en) 2005-09-16 2007-03-22 Schering Corporation Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor
GB0605691D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic Compounds
CN101558062A (zh) 2006-12-19 2009-10-14 诺瓦提斯公司 作为激酶抑制剂的吲哚基马来酰亚胺衍生物
CN104398508B (zh) * 2014-11-28 2017-06-13 上海交通大学 双吲哚马来酰亚胺衍生物在制备治疗慢性粒细胞白血病药物中的应用
CN104693198B (zh) * 2014-12-13 2017-03-08 浙江工业大学 3‑(1,2,4‑三氮唑并[4,3‑a]吡啶‑3‑基)‑4‑(1H‑吲哚‑3‑基)马来酰亚胺类衍生物及其制备方法和应用
CN106146475B (zh) * 2016-06-01 2019-05-17 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
EP0303697B1 (en) * 1987-03-09 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE3914764A1 (de) * 1989-05-05 1990-11-08 Goedecke Ag Maleinimid-derivate und deren verwendung als arzneimittel
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
WO1993018765A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
US5589472A (en) * 1992-09-25 1996-12-31 Vice; Susan F. Diindolo compounds and pharmaceutical compositions containing them
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren

Also Published As

Publication number Publication date
PT766682E (pt) 2001-11-30
DE69522109T2 (de) 2002-04-18
DK0766682T3 (da) 2001-10-08
EP0766682A1 (en) 1997-04-09
EP0766682A4 (en) 1997-09-10
DE69522109D1 (de) 2001-09-13
WO1995035294A1 (en) 1995-12-28
EP0766682B1 (en) 2001-08-08
AU2866995A (en) 1996-01-15
ATE203991T1 (de) 2001-08-15
JPH10502910A (ja) 1998-03-17
ES2159318T3 (es) 2001-10-01
US5491242A (en) 1996-02-13

Similar Documents

Publication Publication Date Title
GR3037074T3 (en) Protein kinase c inhibitors
HK1008183A1 (en) Protein kinase c inhibitors.
DE69626660D1 (en) 2-alkylpyrrolidine
CA2376596A1 (en) Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
WO2001079460A3 (en) Polypeptides having haloperoxidase activity
WO2001079458A3 (en) Polypeptides having haloperoxidase activity
AU2002366641A1 (en) Methods for inhibiting ocular processes
PL330496A1 (en) Methods of and compositions for treating and preventing tumours, disorders associated with tumours as well as cachexy
PL327994A1 (en) Cyclopylin rotamasic activity inhibitors
WO1999061581A3 (en) Sphingosine kinase, cloning, expression and methods of use
ES2088771A1 (es) Metodo para mejorar la acividad reproductora en verracos utilizando alimento para los verracos reproductores.
DE3861462D1 (de) Gasfeuerzeugstruktur, geeignet zur andrueckmontage seiner hauptteile.
GR3034369T3 (en) Alcoholic instant beverage mixture, its production and use
AU4779599A (en) Methods of inhibiting (helicobacter pylori)
IL139303A0 (en) Treatment of arthritis and other similar conditions
IL142255A0 (en) Method of treating heparin-induced thrombocytopenia
ZA200102727B (en) Method of treating sickle cell disease or thalassemia.
CA2193703A1 (en) Protein kinase c inhibitors
EP0646651A3 (en) Method for improving the treatment of leather.
EP1112367B8 (de) Mittel und verfahren zur veränderung des glutaminstoffwechsels in pflanzen, insbesondere in zuckerrüben
UA32363A (uk) Спосіб лікування хронічного алкоголізму

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees