GR3037059T3 - Desosamino derivatives of macrolides as immunosuppressants and antifungal agents. - Google Patents

Desosamino derivatives of macrolides as immunosuppressants and antifungal agents.

Info

Publication number
GR3037059T3
GR3037059T3 GR20010401931T GR20010401931T GR3037059T3 GR 3037059 T3 GR3037059 T3 GR 3037059T3 GR 20010401931 T GR20010401931 T GR 20010401931T GR 20010401931 T GR20010401931 T GR 20010401931T GR 3037059 T3 GR3037059 T3 GR 3037059T3
Authority
GR
Greece
Prior art keywords
macrolides
pct
desosamino
immunosuppressants
derivatives
Prior art date
Application number
GR20010401931T
Other languages
English (en)
Inventor
James R Hauske
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of GR3037059T3 publication Critical patent/GR3037059T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR20010401931T 1992-03-02 2001-10-30 Desosamino derivatives of macrolides as immunosuppressants and antifungal agents. GR3037059T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84435092A 1992-03-02 1992-03-02
PCT/US1993/000426 WO1993018042A1 (en) 1992-03-02 1993-01-27 Desosamino derivatives of macrolides as immunosuppressants and antifungal agents

Publications (1)

Publication Number Publication Date
GR3037059T3 true GR3037059T3 (en) 2002-01-31

Family

ID=25292478

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010401931T GR3037059T3 (en) 1992-03-02 2001-10-30 Desosamino derivatives of macrolides as immunosuppressants and antifungal agents.

Country Status (12)

Country Link
US (2) US5506233A (el)
EP (1) EP0629203B1 (el)
JP (1) JPH07500613A (el)
AT (1) ATE205496T1 (el)
CA (1) CA2131371A1 (el)
DE (1) DE69330747T2 (el)
DK (1) DK0629203T3 (el)
ES (1) ES2160593T3 (el)
FI (1) FI944014A (el)
GR (1) GR3037059T3 (el)
PT (1) PT629203E (el)
WO (1) WO1993018042A1 (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182004C1 (ru) * 2001-02-22 2002-05-10 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственный препарат для парентерального применения
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
PL374059A1 (en) 2002-02-13 2005-09-19 Teva Gyogyszergyar Reszvenytarsasag Method for extracting a macrolide from biomatter
US7232486B2 (en) * 2003-03-31 2007-06-19 TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság Crystallization and purification of macrolides
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
US7160867B2 (en) 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
KR20060052874A (ko) * 2003-07-24 2006-05-19 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 정제 방법
EP2583678A3 (en) 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
TW200637834A (en) * 2004-12-22 2006-11-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying macrolides
CA2588480A1 (en) * 2005-01-05 2006-08-10 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous tacrolimus and preparation thereof
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
TW200815458A (en) * 2006-03-15 2008-04-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for purifying Tacrolimus
JP2009203162A (ja) * 2006-06-05 2009-09-10 Astellas Pharma Inc マクロライド化合物の新規製造法
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
AU6286690A (en) * 1989-08-18 1991-04-03 Fisons Plc Macrocyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
EP0466365A3 (en) * 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism

Also Published As

Publication number Publication date
DE69330747D1 (de) 2001-10-18
US5506233A (en) 1996-04-09
ES2160593T3 (es) 2001-11-16
JPH07500613A (ja) 1995-01-19
PT629203E (pt) 2002-01-30
DE69330747T2 (de) 2002-05-29
CA2131371A1 (en) 1993-09-16
DK0629203T3 (da) 2001-11-12
WO1993018042A1 (en) 1993-09-16
EP0629203A1 (en) 1994-12-21
FI944014A0 (fi) 1994-09-01
EP0629203B1 (en) 2001-09-12
ATE205496T1 (de) 2001-09-15
FI944014A (fi) 1994-09-01
US5563135A (en) 1996-10-08

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Legal Events

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