GR3034317T3 - Glycerolipidic compounds used for the transfer of an active substance into a target cell - Google Patents

Glycerolipidic compounds used for the transfer of an active substance into a target cell

Info

Publication number
GR3034317T3
GR3034317T3 GR20000402004T GR20000402004T GR3034317T3 GR 3034317 T3 GR3034317 T3 GR 3034317T3 GR 20000402004 T GR20000402004 T GR 20000402004T GR 20000402004 T GR20000402004 T GR 20000402004T GR 3034317 T3 GR3034317 T3 GR 3034317T3
Authority
GR
Greece
Prior art keywords
active substance
glycerolipidic
transfer
target cell
alkyl
Prior art date
Application number
GR20000402004T
Other languages
English (en)
Inventor
Rainer Bischoff
Denis Heissler
Abdesslame Nazih
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9701475A external-priority patent/FR2759367A1/fr
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of GR3034317T3 publication Critical patent/GR3034317T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
GR20000402004T 1997-02-10 2000-08-31 Glycerolipidic compounds used for the transfer of an active substance into a target cell GR3034317T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9701475A FR2759367A1 (fr) 1997-02-10 1997-02-10 Glycerolipides cationiques et complexes de glycerolipides cationiques et de substances actives, notamment pour la transfection de cellules
FR9715805A FR2759382A1 (fr) 1997-02-10 1997-12-12 Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
PCT/FR1998/000250 WO1998034910A1 (fr) 1997-02-10 1998-02-10 Composes glycerolipidiques utiles pour le transfert d'une substance active dans une cellule cible

Publications (1)

Publication Number Publication Date
GR3034317T3 true GR3034317T3 (en) 2000-12-29

Family

ID=26233309

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402004T GR3034317T3 (en) 1997-02-10 2000-08-31 Glycerolipidic compounds used for the transfer of an active substance into a target cell

Country Status (13)

Country Link
US (2) US6218370B1 (el)
EP (1) EP0901463B1 (el)
JP (1) JP2000510869A (el)
AT (1) ATE193886T1 (el)
AU (1) AU727204B2 (el)
CA (1) CA2251999A1 (el)
DE (1) DE69800178T2 (el)
DK (1) DK0901463T3 (el)
ES (1) ES2149043T3 (el)
FR (1) FR2759382A1 (el)
GR (1) GR3034317T3 (el)
PT (1) PT901463E (el)
WO (1) WO1998034910A1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759382A1 (fr) * 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
US6849272B1 (en) * 1999-04-21 2005-02-01 Massachusetts Institute Of Technology Endosomolytic agents and cell delivery systems
EP1052288A1 (en) * 1999-05-10 2000-11-15 Transgene S.A. Complex for transferring an anionic substance of interest into a cell
EP1052287A3 (en) * 1999-05-10 2003-07-09 Transgene S.A. Complex for transferring an anionic substance of interest into a cell
WO2001042200A1 (en) * 1999-12-10 2001-06-14 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US20030229037A1 (en) * 2000-02-07 2003-12-11 Ulrich Massing Novel cationic amphiphiles
GB0106041D0 (en) * 2001-03-12 2001-05-02 Cancer Res Ventures Ltd Lipids and liposomes
US20070111201A1 (en) * 2001-04-30 2007-05-17 Benjamin Doranz Reverse transfection of cell arrays for structural and functional analyses of proteins
CA2447548A1 (en) * 2001-05-15 2002-11-21 Transgene S.A. Complexes for transferring substances of interest into a cell
WO2003099830A2 (en) * 2002-05-24 2003-12-04 Neopharm, Inc. Cardiolipin compositions, methods of preparation and use
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof
CA2532783C (en) 2003-07-21 2013-09-17 Transgene S.A. Polypeptide having an improved cytosine deaminase activity
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
WO2005039558A1 (en) * 2003-10-24 2005-05-06 Transgene S.A. Targeted delivery of therapeutically active compounds
WO2005056752A2 (en) 2003-10-24 2005-06-23 Gencia Corporation Methods and compositions for delivering polynucleotides
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
ATE445274T1 (de) * 2004-08-05 2009-10-15 Lg Electronics Inc Unterbrechung der benutzung des frequenzschichtkonvergenzverfahrens
GB0425556D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd Novel compounds
JP5172188B2 (ja) * 2007-03-28 2013-03-27 富士フイルム株式会社 フッ素置換アルキル基を有するグリセリド化合物
US8357531B2 (en) 2007-07-03 2013-01-22 Transgene S.A. Immortalized avian cell lines
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.
US8470977B2 (en) 2008-03-14 2013-06-25 Transgene S.A. Antibody against the CSF-1R
BRPI1006179A2 (pt) 2009-01-13 2016-02-23 Transgène S A uso de uma fração de ácidos nucleicos mitocondriais, composição adjuvante, composição de vacina, e, kit da parte
CN110418650A (zh) 2016-11-16 2019-11-05 免疫治疗有限公司 用于治疗过敏的核酸
AU2018263923A1 (en) 2017-05-02 2019-10-31 Immunomic Therapeutics, Inc. LAMP (lysosomal associated membrane protein) constructs comprising cancer antigens
WO2019222281A1 (en) 2018-05-15 2019-11-21 Immunomic Therapeutics, Inc Improved lamp constructs comprising allergens
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
CA3153850A1 (en) 2019-10-18 2021-04-22 Teri Heiland Improved lamp constructs comprising cancer antigens
AU2020385683A1 (en) 2019-11-18 2022-06-30 Janssen Biotech, Inc. Vaccines based on mutant CALR and JAK2 and their uses
US20230035403A1 (en) 2020-07-06 2023-02-02 Janssen Biotech, Inc. Method For Determining Responsiveness To Prostate Cancer Treatment
US20230024133A1 (en) 2020-07-06 2023-01-26 Janssen Biotech, Inc. Prostate Neoantigens And Their Uses
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2023201201A1 (en) 2022-04-10 2023-10-19 Immunomic Therapeutics, Inc. Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2958076B2 (ja) * 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
CA2156289C (en) * 1993-02-19 2006-01-03 Junichi Yano Drug composition containing nucleic acid copolymer
DE19521412A1 (de) * 1995-06-14 1996-12-19 Boehringer Mannheim Gmbh Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
GB9512363D0 (en) * 1995-06-17 1995-08-16 Bass Plc Liquid containers and method of manufacture thereof
FR2759382A1 (fr) * 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique

Also Published As

Publication number Publication date
ATE193886T1 (de) 2000-06-15
AU6626698A (en) 1998-08-26
EP0901463B1 (fr) 2000-06-14
DE69800178D1 (de) 2000-07-20
DK0901463T3 (da) 2000-10-23
US6218370B1 (en) 2001-04-17
AU727204B2 (en) 2000-12-07
US6743781B2 (en) 2004-06-01
EP0901463A1 (fr) 1999-03-17
DE69800178T2 (de) 2001-02-15
JP2000510869A (ja) 2000-08-22
ES2149043T3 (es) 2000-10-16
WO1998034910A1 (fr) 1998-08-13
FR2759382A1 (fr) 1998-08-14
PT901463E (pt) 2000-12-29
CA2251999A1 (fr) 1998-08-13
US20010036927A1 (en) 2001-11-01

Similar Documents

Publication Publication Date Title
GR3034317T3 (en) Glycerolipidic compounds used for the transfer of an active substance into a target cell
HU9500503D0 (en) Derivatives of valproic and 2-valproenoic acid amides and use anticonvulsants
NZ290757A (en) Delivery of nucleic acid into a cell
CA2222329A1 (en) 4-substituted-phenyl-boronic acids as enzyme stabilizers
AP9701007A0 (en) Substituted azetidin-2-ones for treatment of atherosclerosis.
NZ335157A (en) N-(aryl/heteroaryl) amino acid derivatives and methods for inhibiting beta-amyloid peptide release or its synthesis
ES8704470A1 (es) Procedimiento para la determinacion optica de la lipasa
MXPA03000547A (es) Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
TW238304B (en) A process for the preparation of 1-substituted-5(4H)-tetrazolinones
ES8800287A1 (es) Procedimiento de preparar copolimeros formadores de pelicula
MX170732B (es) Composicion de derivados de succinimida y su uso
MX9605737A (es) Transfeccion de celulas.
EP1028721A4 (en) N, N'-BIS (SULFONYL) HYDRAZINES FOR USE AS ANTINEOPLASTIC AGENTS
EA200001107A1 (ru) ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
ES8303434A1 (es) Procedimiento para la obtencion de amidas del ester de acido fosforico (fosfonico).
AU4458897A (en) Improved method for the determination of lipase
TW328083B (en) New derivatives of β-methoxy acrylic acid, their preparation process and their use as pesticides
ATE61341T1 (de) N-substituierte, estergruppen enthaltende acrylamide.
ES451762A1 (es) Procedimiento para la obtencion de esteres de acidos fosfo- ricos.
DE3665587D1 (en) Oximino phosphoric-acid derivatives, process for their preparation and their use as pesticides
PT1230223E (pt) Derivados de oligobenzimidazoles e a sua utilizacao como agentes de transfeccao de adn
DE3561948D1 (en) Oximinophosphoric acid derivatives, process for their preparation and their use as pesticides
DE59505456D1 (de) Avivagemittel mit verbessertem wiederbenetzungsvermögen
ES481741A1 (es) Procedimiento para la obtencion de o-(amino alquil) oximas diaromaticas.
TW340847B (en) Compound of ether series and herbicidal agents containing the said compound as effective component

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees