GR3022358T3 - Beta retinoic acid response elements compositions and assays - Google Patents
Beta retinoic acid response elements compositions and assaysInfo
- Publication number
- GR3022358T3 GR3022358T3 GR960402829T GR960402829T GR3022358T3 GR 3022358 T3 GR3022358 T3 GR 3022358T3 GR 960402829 T GR960402829 T GR 960402829T GR 960402829 T GR960402829 T GR 960402829T GR 3022358 T3 GR3022358 T3 GR 3022358T3
- Authority
- GR
- Greece
- Prior art keywords
- response elements
- retinoic acid
- assays
- beta
- acid response
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- High Energy & Nuclear Physics (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/438,757 US5091518A (en) | 1989-11-16 | 1989-11-16 | Beta retinoic acid response elements compositions and assays |
PCT/US1990/006626 WO1991007488A1 (en) | 1989-11-16 | 1990-11-13 | Beta retinoic acid response elements compositions and assays |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3022358T3 true GR3022358T3 (en) | 1997-04-30 |
Family
ID=23741886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR960402829T GR3022358T3 (en) | 1989-11-16 | 1997-01-23 | Beta retinoic acid response elements compositions and assays |
Country Status (11)
Country | Link |
---|---|
US (1) | US5091518A (el) |
EP (1) | EP0502979B1 (el) |
JP (1) | JPH05504474A (el) |
AT (1) | ATE148166T1 (el) |
AU (1) | AU637871B2 (el) |
CA (1) | CA2072644A1 (el) |
DE (1) | DE69029812T2 (el) |
DK (1) | DK0502979T3 (el) |
ES (1) | ES2095931T3 (el) |
GR (1) | GR3022358T3 (el) |
WO (1) | WO1991007488A1 (el) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260432A (en) * | 1989-06-22 | 1993-11-09 | Sloan-Kettering Institute For Cancer Research | Human gamma retinoic acid receptor DNA |
US6492137B1 (en) * | 1989-11-16 | 2002-12-10 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
US5091518A (en) * | 1989-11-16 | 1992-02-25 | The Salk Institute For Biological Studies | Beta retinoic acid response elements compositions and assays |
US5861274A (en) * | 1990-03-22 | 1999-01-19 | The Salk Institute For Biological Studies | Nucleic acids encoding peroxisome proliferator-activated receptor |
US6440681B1 (en) | 1990-04-03 | 2002-08-27 | Merck & Co., Inc. | Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors |
US5369028A (en) * | 1990-04-03 | 1994-11-29 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
WO1992006715A1 (en) * | 1990-10-12 | 1992-04-30 | Seragen, Inc. | Mammalian model of a malignant disorder |
WO1992011365A1 (en) * | 1990-12-21 | 1992-07-09 | The Rockefeller University | Liver enriched transcription factor |
WO1992016658A1 (en) * | 1991-03-18 | 1992-10-01 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
SE500453C2 (sv) * | 1991-10-07 | 1994-06-27 | Karobio Ab | Ett in vitro förfarande för utvärdering av en substans effekter |
EP0552612A3 (en) * | 1992-01-22 | 1993-10-20 | Hoffmann La Roche | Methods for determining and isolating compounds which bind directly to nucleosolic proteins |
US5756448A (en) * | 1992-02-26 | 1998-05-26 | The General Hospital Corporation | Constitute activator of retinoid (CAR) receptor polypeptides |
US6989242B1 (en) | 1992-02-26 | 2006-01-24 | The General Hospital Coporation | Car receptors and related molecules and methods |
ES2229216T3 (es) * | 1993-03-08 | 2005-04-16 | MERCK & CO., INC. | Composiciones de receptores nicotinicos neurales humanos de acetilcolina y procedimientos que emplean las mismas. |
WO1995013299A1 (en) * | 1993-11-08 | 1995-05-18 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
JPH10502256A (ja) * | 1994-07-01 | 1998-03-03 | ザ ソールク インスチチュート フォア バイオロジカル スタディズ | 哺乳動物のペルオキシソーム増殖物質活性化受容体およびその使用 |
US5702914A (en) * | 1994-12-21 | 1997-12-30 | The Salk Institute For Biological Studies | Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements |
FR2732035B1 (fr) * | 1995-03-23 | 1997-05-30 | Agronomique Inst Nat Rech | Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede |
US6485967B1 (en) | 1995-06-07 | 2002-11-26 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid |
FR2735371B1 (fr) * | 1995-06-19 | 1997-07-18 | Cird Galderma | Procede pour identifier des composes antagonistes des recepteurs rars |
US6489441B1 (en) | 1995-09-01 | 2002-12-03 | The Salk Institute For Biological Studies | Transcriptional co-repressor that interacts with nuclear hormone receptors |
WO1997034144A1 (de) * | 1996-03-14 | 1997-09-18 | Schering Aktiengesellschaft | Verfahren zum nachweis der wirkung von testsubstanzen unter verwendung von hühner-urokinase |
JP2002505573A (ja) | 1997-04-24 | 2002-02-19 | アンスティテュ ナショナル デュ ラ サンテ エ デュ ラ ルシェルシュ メディカル | マトリックスメタロプロテイナーゼ遺伝子の発現を調節することにおける使用のための方法および組成物 |
US6387673B1 (en) | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
AU1395999A (en) * | 1997-11-10 | 1999-05-31 | Salk Institute For Biological Studies, The | Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases |
CN106480024B (zh) * | 2015-08-30 | 2020-10-20 | 南通大学附属医院 | 受维甲酸调控的具有浓度依赖效应的重组启动子及其使用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02500161A (ja) * | 1986-08-01 | 1990-01-25 | ジェネテイックス・インスティテュート・インコーポレイテッド | 異種遺伝子の高水準誘導発現 |
US5091518A (en) * | 1989-11-16 | 1992-02-25 | The Salk Institute For Biological Studies | Beta retinoic acid response elements compositions and assays |
EP0514488B1 (en) * | 1990-02-09 | 2000-09-13 | The Salk Institute For Biological Studies | Retinoid receptor compositions and methods |
CA2075192A1 (en) * | 1990-03-22 | 1991-09-23 | Anthony E. Oro | Insect retinoid receptor compositions and methods |
-
1989
- 1989-11-16 US US07/438,757 patent/US5091518A/en not_active Expired - Lifetime
-
1990
- 1990-11-13 CA CA002072644A patent/CA2072644A1/en not_active Abandoned
- 1990-11-13 ES ES91901044T patent/ES2095931T3/es not_active Expired - Lifetime
- 1990-11-13 WO PCT/US1990/006626 patent/WO1991007488A1/en active IP Right Grant
- 1990-11-13 AU AU69568/91A patent/AU637871B2/en not_active Ceased
- 1990-11-13 EP EP91901044A patent/EP0502979B1/en not_active Expired - Lifetime
- 1990-11-13 AT AT91901044T patent/ATE148166T1/de not_active IP Right Cessation
- 1990-11-13 JP JP3501472A patent/JPH05504474A/ja active Pending
- 1990-11-13 DK DK91901044.7T patent/DK0502979T3/da active
- 1990-11-13 DE DE69029812T patent/DE69029812T2/de not_active Expired - Fee Related
-
1997
- 1997-01-23 GR GR960402829T patent/GR3022358T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1991007488A1 (en) | 1991-05-30 |
AU637871B2 (en) | 1993-06-10 |
EP0502979A1 (en) | 1992-09-16 |
EP0502979B1 (en) | 1997-01-22 |
ATE148166T1 (de) | 1997-02-15 |
DE69029812D1 (de) | 1997-03-06 |
DE69029812T2 (de) | 1997-06-05 |
AU6956891A (en) | 1991-06-13 |
US5091518A (en) | 1992-02-25 |
ES2095931T3 (es) | 1997-03-01 |
CA2072644A1 (en) | 1991-05-17 |
EP0502979A4 (en) | 1993-02-10 |
DK0502979T3 (da) | 1997-04-07 |
JPH05504474A (ja) | 1993-07-15 |
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