GR3007427T3 - - Google Patents
Info
- Publication number
- GR3007427T3 GR3007427T3 GR920403233T GR920403233T GR3007427T3 GR 3007427 T3 GR3007427 T3 GR 3007427T3 GR 920403233 T GR920403233 T GR 920403233T GR 920403233 T GR920403233 T GR 920403233T GR 3007427 T3 GR3007427 T3 GR 3007427T3
- Authority
- GR
- Greece
- Prior art keywords
- disulphide
- cystine
- molar excess
- creatine kinase
- methyl
- Prior art date
Links
- 102000004420 Creatine Kinase Human genes 0.000 abstract 2
- 108010042126 Creatine kinase Proteins 0.000 abstract 2
- ZTVZLYBCZNMWCF-UHFFFAOYSA-N homocystine Chemical compound [O-]C(=O)C([NH3+])CCSSCCC([NH3+])C([O-])=O ZTVZLYBCZNMWCF-UHFFFAOYSA-N 0.000 abstract 2
- WQABAGNOIRGXHH-WHFBIAKZSA-N (2r)-2-amino-3-[[(2r)-2-amino-3-methoxy-3-oxopropyl]disulfanyl]propanoic acid Chemical compound COC(=O)[C@@H](N)CSSC[C@H](N)C(O)=O WQABAGNOIRGXHH-WHFBIAKZSA-N 0.000 abstract 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- XYONNSVDNIRXKZ-UHFFFAOYSA-N S-methyl methanethiosulfonate Chemical compound CSS(C)(=O)=O XYONNSVDNIRXKZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 abstract 1
- 229940099500 cystamine Drugs 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853540076 DE3540076A1 (de) | 1985-11-12 | 1985-11-12 | Verfahren zur stabilisierung von creatinkinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3007427T3 true GR3007427T3 (enExample) | 1993-07-30 |
Family
ID=6285753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR920403233T GR3007427T3 (enExample) | 1985-11-12 | 1993-03-23 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4931392A (enExample) |
| EP (1) | EP0222380B1 (enExample) |
| JP (1) | JPS62118887A (enExample) |
| AT (1) | ATE87030T1 (enExample) |
| DE (2) | DE3540076A1 (enExample) |
| ES (1) | ES2054609T3 (enExample) |
| GR (1) | GR3007427T3 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2028593C (en) * | 1989-10-31 | 2007-08-21 | Douglas R. Brandt | Stabilized enzyme compositions |
| DE4011084A1 (de) * | 1990-04-05 | 1991-10-10 | Boehringer Mannheim Gmbh | Saccharid-modifizierte, wasserloesliche proteine |
| US5217890A (en) * | 1991-08-20 | 1993-06-08 | Eastman Kodak Company | Stabilized composition containing creatine kinase and protein having blocked sulfhydryl groups |
| US5298406A (en) * | 1992-09-14 | 1994-03-29 | E. I. Du Pont De Nemours And Company | Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes |
| US5405769A (en) * | 1993-04-08 | 1995-04-11 | National Research Council Of Canada | Construction of thermostable mutants of a low molecular mass xylanase |
| AU678613B2 (en) * | 1993-09-22 | 1997-06-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
| US5849301A (en) * | 1993-09-22 | 1998-12-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents |
| US6309646B1 (en) | 1996-05-09 | 2001-10-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates |
| DE19627075A1 (de) * | 1996-07-05 | 1998-01-15 | Boehringer Mannheim Gmbh | Modifizierte Lactatdehydrogenase, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| CA2296770A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US5981249A (en) * | 1998-02-05 | 1999-11-09 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising creatine kinase M and creatine kinase B |
| CA2359345A1 (en) * | 1999-01-14 | 2000-07-20 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| DE60118621T2 (de) * | 2000-10-27 | 2007-05-03 | The Johns Hopkins University | Verfahren zur bestimmung der nitrosylierung von proteinen |
| EP1405907A3 (en) * | 2002-07-22 | 2004-10-13 | Roche Diagnostics GmbH | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| CA2433479A1 (en) * | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| CN105264384B (zh) * | 2013-05-06 | 2018-04-27 | 生物辐射实验室股份有限公司 | 参比材料中不稳定分析物的稳定化 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876501A (en) * | 1973-05-17 | 1975-04-08 | Baxter Laboratories Inc | Binding enzymes to activated water-soluble carbohydrates |
| US4339533A (en) * | 1980-07-30 | 1982-07-13 | Technicon Instruments Corporation | Stabilization of creatine kinase (CK) and its application as a reference standard |
| US4652524A (en) * | 1980-10-02 | 1987-03-24 | Ivan E. Modrovich | Soluble stabilized enzymes |
-
1985
- 1985-11-12 DE DE19853540076 patent/DE3540076A1/de not_active Ceased
-
1986
- 1986-11-12 EP EP86115699A patent/EP0222380B1/de not_active Expired - Lifetime
- 1986-11-12 ES ES86115699T patent/ES2054609T3/es not_active Expired - Lifetime
- 1986-11-12 AT AT86115699T patent/ATE87030T1/de not_active IP Right Cessation
- 1986-11-12 JP JP61267907A patent/JPS62118887A/ja active Granted
- 1986-11-12 DE DE8686115699T patent/DE3688041D1/de not_active Expired - Fee Related
-
1989
- 1989-05-15 US US07/355,039 patent/US4931392A/en not_active Expired - Fee Related
-
1993
- 1993-03-23 GR GR920403233T patent/GR3007427T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0222380B1 (de) | 1993-03-17 |
| US4931392A (en) | 1990-06-05 |
| JPH0335920B2 (enExample) | 1991-05-29 |
| ATE87030T1 (de) | 1993-04-15 |
| JPS62118887A (ja) | 1987-05-30 |
| DE3688041D1 (de) | 1993-04-22 |
| ES2054609T3 (es) | 1994-08-16 |
| EP0222380A2 (de) | 1987-05-20 |
| EP0222380A3 (en) | 1989-01-04 |
| DE3540076A1 (de) | 1987-05-14 |
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