GR20010100601A - Προτυπα αναφορας για τον προσδιορισμο της καθαροτητας ή σταθεροτητας της μιλεινικης αμλοδιπινης και διεργασιες για αυτα. - Google Patents

Προτυπα αναφορας για τον προσδιορισμο της καθαροτητας ή σταθεροτητας της μιλεινικης αμλοδιπινης και διεργασιες για αυτα.

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Publication number
GR20010100601A
GR20010100601A GR20010100601A GR2001100601A GR20010100601A GR 20010100601 A GR20010100601 A GR 20010100601A GR 20010100601 A GR20010100601 A GR 20010100601A GR 2001100601 A GR2001100601 A GR 2001100601A GR 20010100601 A GR20010100601 A GR 20010100601A
Authority
GR
Greece
Prior art keywords
purity
determining
stability
reference standards
amlodipine maleate
Prior art date
Application number
GR20010100601A
Other languages
English (en)
Other versions
GR1004672B (el
Inventor
Frantisek Picha
Petrus Franciscus Antonius Bakker
Theodorus Hendricus Antonius Peters
Jacobus Maria Lemmens
Original Assignee
Bioorganics B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29740329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR20010100601(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioorganics B.V. filed Critical Bioorganics B.V.
Publication of GR20010100601A publication Critical patent/GR20010100601A/el
Publication of GR1004672B publication Critical patent/GR1004672B/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
    • G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)

Abstract

ασπαρτική αμλοδιπίνη και το μηλεϊναμίδιο της αμλοδιπίνης χρησιμοποιούνται ως πρότυπα αναφοράς ή ως δείκτες στο προσδιορισμό της καθαρότητας ουσιών μηλεϊνικής αμλοδιπίνης και προϊόντων. ΰ
GR20010100601A 2000-12-29 2001-12-28 Προτυπα αναφορας για τον προσδιορισμο της καθαροτητας ή σταθεροτητας της μιλεινικης αμλοδιπινης και διεργασιες για αυτα. GR1004672B (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25860100P 2000-12-29 2000-12-29
US80934701A 2001-03-16 2001-03-16
PCT/NL2001/000605 WO2002054062A2 (en) 2000-12-29 2001-08-15 Reference standards and processes for determining the purity or stability of amlodipine maleate
BE2001/0713A BE1014456A6 (nl) 2000-12-29 2001-11-05 Referentiestandaarden voor het bepalen van de zuiverheid of stabiliteit van amlodipinemaleaat en werkwijzen daarvoor.

Publications (2)

Publication Number Publication Date
GR20010100601A true GR20010100601A (el) 2002-10-09
GR1004672B GR1004672B (el) 2004-09-13

Family

ID=29740329

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010100601A GR1004672B (el) 2000-12-29 2001-12-28 Προτυπα αναφορας για τον προσδιορισμο της καθαροτητας ή σταθεροτητας της μιλεινικης αμλοδιπινης και διεργασιες για αυτα.

Country Status (12)

Country Link
US (1) US6830933B2 (el)
EP (1) EP1346214A2 (el)
BE (1) BE1014456A6 (el)
CA (2) CA2433284A1 (el)
DE (1) DE20116639U1 (el)
DK (2) DK200300348U4 (el)
FI (1) FI6789U1 (el)
GB (1) GB2371862B (el)
GR (1) GR1004672B (el)
HU (1) HUP0105457A3 (el)
IE (1) IES20011106A2 (el)
WO (1) WO2002054062A2 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053541A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate
WO2007069264A2 (en) * 2005-12-15 2007-06-21 Alembic Limited Reference standards for determining the purity of telithromycin and processes therefor
CA2680277A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0809893A2 (pt) * 2007-05-01 2014-09-30 Chemagis Ltd Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
CA2685488A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
EP0244944A2 (en) 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
EP0963980A2 (en) * 1998-06-10 1999-12-15 The Wellcome Foundation Limited 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine"
WO2002053134A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Pharmaceutical compositions comprising amlodipine maleate
US20020143046A1 (en) * 2000-12-29 2002-10-03 Peters Theodorus H. A. Process for making amlodipine, derivatives therof, and precursors therefor

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US4983740A (en) * 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) * 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
ZA9810320B (en) 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
PL189666B1 (pl) 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
CZ20031779A3 (cs) 2000-12-29 2004-10-13 Bioorganicsáb@V Způsob přípravy amlodipinuŹ jeho derivátů a jejich prekurzorů

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
US4572909A (en) 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
EP0244944A2 (en) 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
US4879303A (en) 1986-04-04 1989-11-07 Pfizer Inc. Pharmaceutically acceptable salts
EP0963980A2 (en) * 1998-06-10 1999-12-15 The Wellcome Foundation Limited 1,2,4-Triazine derivative, its preparation and its use as reference marker for testing purity and stability of "lamotrigine"
WO2002053134A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Pharmaceutical compositions comprising amlodipine maleate
US20020143046A1 (en) * 2000-12-29 2002-10-03 Peters Theodorus H. A. Process for making amlodipine, derivatives therof, and precursors therefor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PANDYA K K ET AL: "Detection and determination of total amlodipine by high-performance thin-layer chromatography: a useful technique for pharmacokinetic studies", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 667, no. 2, 19 May 1995 (1995-05-19), pages 315 - 320, XP004043869, ISSN: 0378-4347 *
SZIKSZAY Z ET AL: "QUANTITATIVE PURITY TEST FOR PHTHALOYL-AMLODIPINE BY PERSONAL OPLC", JPC. JOURNAL OF PLANAR CHROMATOGRAPHY, MODERN TLC, HUETHIG, HEIDELBERG, DE, vol. 11, no. 6, 16 May 1988 (1988-05-16), pages 428 - 432, XP008007919, ISSN: 0933-4173 *
TATAR S ET AL: "Determination of amlodipine in human plasma by high-performance liquid chromatography with fluorescence detection", JOURNAL OF CHROMATOGRAPHY. BIOMEDICAL APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 758, no. 2, 15 July 2001 (2001-07-15), pages 305 - 310, XP004242085, ISSN: 0378-4347 *
ZMITEK J ET AL: "SOURCES OF IMPURITIES - INVESTIGATION OF 4-(2-CHLOROPHENYL)-3-ETHOXYC ARBONYL-5-METHOXYCARBONYL-6-METHYL-2-Ä(2-PHTHALIMIDOETHOXY)METHYLÜ-1, 4-DIHYDROPYRIDINE TRACES FORMATION DURING THE SYNTHESIS OF AMLODIPINE BESYLATE", ACTA CHIMICA SLOVENICA, SLOVENSKO KEMIJSKO DRUSTVO, LJUBLJANA, SI, vol. 47, no. 1, 2000, pages 63 - 68, XP001105759, ISSN: 1318-0207 *

Also Published As

Publication number Publication date
US20020137223A1 (en) 2002-09-26
GB2371862B (en) 2004-07-14
DK200300348U4 (da) 2004-04-23
DK200300349U3 (da) 2004-03-12
GB2371862A (en) 2002-08-07
HU0105457D0 (en) 2002-02-28
CA2366398A1 (en) 2002-06-29
FI6789U1 (fi) 2005-09-14
BE1014456A6 (nl) 2003-10-07
DE20116639U1 (de) 2002-01-17
GB0131113D0 (en) 2002-02-13
CA2433284A1 (en) 2002-07-11
WO2002054062A2 (en) 2002-07-11
EP1346214A2 (en) 2003-09-24
DK200300348U1 (da) 2003-12-12
HUP0105457A3 (en) 2003-12-29
FIU20030477U0 (fi) 2003-12-17
WO2002054062A3 (en) 2003-05-22
HUP0105457A2 (en) 2002-10-28
GR1004672B (el) 2004-09-13
US6830933B2 (en) 2004-12-14
IES20011106A2 (en) 2002-12-30

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