GR1006780B - Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους - Google Patents

Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους

Info

Publication number
GR1006780B
GR1006780B GR20090100219A GR20090100219A GR1006780B GR 1006780 B GR1006780 B GR 1006780B GR 20090100219 A GR20090100219 A GR 20090100219A GR 20090100219 A GR20090100219 A GR 20090100219A GR 1006780 B GR1006780 B GR 1006780B
Authority
GR
Greece
Prior art keywords
spheroids
pellets
granules
rapidly disintegrating
producing rapidly
Prior art date
Application number
GR20090100219A
Other languages
English (en)
Inventor
Original Assignee
Specifar Abee ���������� ������� ��� ������������� ���������
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Specifar Abee ���������� ������� ��� ������������� ��������� filed Critical Specifar Abee ���������� ������� ��� ������������� ���������
Priority to GR20090100219A priority Critical patent/GR1006780B/el
Priority to CA2757752A priority patent/CA2757752A1/en
Priority to PCT/EP2009/056618 priority patent/WO2010115475A1/en
Priority to US13/263,613 priority patent/US20120027822A1/en
Publication of GR1006780B publication Critical patent/GR1006780B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά σε διεργασίες παραγωγής ταχέως αποσαθρούμενων σφαιριδίων, κοκκίων ή/και μειγμάτων τους, τα οποία αποσαθρώνονται σε χρόνο μικρότερο των 15 λεπτών, όπου τα σφαιρίδια περιέχουν τουλάχιστον μία φαρμακολογία δραστική ουσία έναν παράγοντασφαιροποίησης, μία στερεή Πολυαιθυλενογλυκόλη (ΠΕΓ) με μέσο μοριακό βάρος (ΜΒ) μεγαλύτερο του 1.000 και η διεργασία χαρακτηρίζεται από την παρουσία ενός σταδίου άμεσης σφαιροποίησης που λαμβάνει χώρα σε μία διάταξη ρευστής κλίνης με ρότορα, εφαρμόζοντας υδατικά συνδετικά μέσα και η θερμοκρασία κατά τη διεργασία δεν υπερβαίνει το σημείο τήξεως τηςστερεής ΠΕΓ.
GR20090100219A 2009-04-10 2009-04-10 Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους GR1006780B (el)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GR20090100219A GR1006780B (el) 2009-04-10 2009-04-10 Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους
CA2757752A CA2757752A1 (en) 2009-04-10 2009-05-29 Process for producing rapidly disintegrating spheroids (pellets), granules and/or mixtures thereof
PCT/EP2009/056618 WO2010115475A1 (en) 2009-04-10 2009-05-29 Process for producing rapidly disintegrating spheroids (pellets), granules and/or mixtures thereof
US13/263,613 US20120027822A1 (en) 2009-04-10 2009-05-29 Process for Producing Rapidly Disintegrating Spheroids (Pellets), Granules and/or Mixtures Thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20090100219A GR1006780B (el) 2009-04-10 2009-04-10 Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους

Publications (1)

Publication Number Publication Date
GR1006780B true GR1006780B (el) 2010-05-20

Family

ID=41337095

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20090100219A GR1006780B (el) 2009-04-10 2009-04-10 Διεργασια παραγωγης ταχεως αποσαθρουμενων σφαιριδιων, κοκκιων και/'η μιγματων τους

Country Status (4)

Country Link
US (1) US20120027822A1 (el)
CA (1) CA2757752A1 (el)
GR (1) GR1006780B (el)
WO (1) WO2010115475A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CN106860408B (zh) * 2015-12-14 2021-06-22 山东新时代药业有限公司 一种格列美脲片
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
WO2022154687A1 (ru) * 2021-01-14 2022-07-21 Общество C Ограниченной Ответственностью "Новамедика" Фармацевтическая композиция, включающая эзомепразол
CN114504580B (zh) * 2021-12-28 2024-04-16 湖南醇健制药科技有限公司 一种大批量制备熊去氧胆酸制剂的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1972336A1 (en) * 2007-03-19 2008-09-24 LEK Pharmaceuticals D.D. Hot-melt micropellets

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1972336A1 (en) * 2007-03-19 2008-09-24 LEK Pharmaceuticals D.D. Hot-melt micropellets

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KRISTENSEN J: "Investigation of a 2-Step Agglomeration Process Performed in a Rotary Processor Using Polyethylene Glycol Solutions as the Primary Binder Liquid", AAPS PHARMSCITECH, vol. 7, no. 4, 27 October 2006 (2006-10-27), American Association of Pharmaceutical Scientists, pages E1 - E8, XP002560845 *
LAOHAVICHIEN A ET AL: "Effect of binders, disintegrants and their interactions on fluidized bed produced tablet characteristics", PHARMAZEUTISCHE INDUSTRIE, AULENDORF, DE, vol. 62, no. 12, 1 January 2000 (2000-01-01), pages 992 - 998, XP009109920, ISSN: 0031-711X *
NICKLASSON F, ALDERBORN G: "Modulation of the tabletting behaviour of microcrystalline cellulose pellets by the incorporation of polyethylene glycol", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES., vol. 9, 24 June 1999 (1999-06-24), ELSEVIER, AMSTERDAM., pages 57 - 65, XP002560846 *

Also Published As

Publication number Publication date
CA2757752A1 (en) 2010-10-14
US20120027822A1 (en) 2012-02-02
WO2010115475A1 (en) 2010-10-14

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Effective date: 20141104