GR1005093B - Αναλογα της σκυφοστατινης και ενδιαμεσα για την παραγωγη αυτων - Google Patents
Αναλογα της σκυφοστατινης και ενδιαμεσα για την παραγωγη αυτωνInfo
- Publication number
- GR1005093B GR1005093B GR20050100044A GR20050100044A GR1005093B GR 1005093 B GR1005093 B GR 1005093B GR 20050100044 A GR20050100044 A GR 20050100044A GR 20050100044 A GR20050100044 A GR 20050100044A GR 1005093 B GR1005093 B GR 1005093B
- Authority
- GR
- Greece
- Prior art keywords
- scyphostatin
- intermediates
- production
- analogues
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά στη σύνθεση της σκυφοστατίνης καθώς και αναλόγων αυτής. Ειδικότερα η παρούσα εφεύρεση αφορά στη σύνθεση του εποξυκυκλοεξενικού πυρήνα της σκυφοστατίνης και παραγώγων αυτού. Αυτές οι χημικές ενώσεις αναμένεται να είναι ισχυροί και εκλεκτικοί παρεμποδιστές του ενζύμου ουδέτερη σφιγκομυελινάση (N-SMase) και επομένως να έχουνφαρμακευτική χρήση για την αντιμετώπιση ασθενειώνόπως μόλυνση από τον ιό ανθρώπινης ανοσοανεπάρκειας (HIV), νευροεκφυλιστικές ασθένειες, φλεγμονώδεις ασθένειες, ισχαιμία, αποπληξία ή αρτηριοσκλήρυνση.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20050100044A GR1005093B (el) | 2005-02-01 | 2005-02-01 | Αναλογα της σκυφοστατινης και ενδιαμεσα για την παραγωγη αυτων |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20050100044A GR1005093B (el) | 2005-02-01 | 2005-02-01 | Αναλογα της σκυφοστατινης και ενδιαμεσα για την παραγωγη αυτων |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1005093B true GR1005093B (el) | 2006-01-13 |
Family
ID=37502727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20050100044A GR1005093B (el) | 2005-02-01 | 2005-02-01 | Αναλογα της σκυφοστατινης και ενδιαμεσα για την παραγωγη αυτων |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1005093B (el) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105555775A (zh) * | 2013-09-13 | 2016-05-04 | 比亚尔-波特拉&Ca有限公司 | 制备用于治疗心血管疾病的药物及其中使用的中间体的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1234816A1 (de) * | 2001-02-23 | 2002-08-28 | Hans-Peter Dr. Deigner | Scyphostatin-Analoga als SMase-Inhibitoren |
-
2005
- 2005-02-01 GR GR20050100044A patent/GR1005093B/el not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1234816A1 (de) * | 2001-02-23 | 2002-08-28 | Hans-Peter Dr. Deigner | Scyphostatin-Analoga als SMase-Inhibitoren |
Non-Patent Citations (3)
Title |
---|
INOUE, MUNENORI ET AL: "Total synthesis of (+)-scyphostatin, A potent and specific inhibitor of neutral sphingomyelinase", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION , 43(32), 4207-4209 CODEN: ACIEF5; ISSN: 1433-7851, 2004, XP002346651 * |
PITSINOS, EMMANUEL N. ET AL: "Synthesis and evaluation of three novel scyphostatin analogs as neutral sphingomyelinase inhibitors", CHEMBIOCHEM , 4(11), 1223-1225 CODEN: CBCHFX; ISSN: 1439-4227, 2003, XP002346652 * |
TANAKA, MASAHIRO ET AL: "Structural Elucidation of Scyphostatin, an Inhibitor of Membrane-Bound Neutral Sphingomyelinase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 119(33), 7871-7872 CODEN: JACSAT; ISSN: 0002-7863, 1997, XP002346653 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105555775A (zh) * | 2013-09-13 | 2016-05-04 | 比亚尔-波特拉&Ca有限公司 | 制备用于治疗心血管疾病的药物及其中使用的中间体的方法 |
US10329268B2 (en) | 2013-09-13 | 2019-06-25 | Bial-Portela & Ca, S.A. | Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PG | Patent granted | ||
ML | Lapse due to non-payment of fees |