GR1000477B - Νεο μονοκλωνικο αντισωμα κατα νεου αντιγονου που σχετιζεται με ανθρωπινους ογκους. - Google Patents
Νεο μονοκλωνικο αντισωμα κατα νεου αντιγονου που σχετιζεται με ανθρωπινους ογκους.Info
- Publication number
- GR1000477B GR1000477B GR900100221A GR900100221A GR1000477B GR 1000477 B GR1000477 B GR 1000477B GR 900100221 A GR900100221 A GR 900100221A GR 900100221 A GR900100221 A GR 900100221A GR 1000477 B GR1000477 B GR 1000477B
- Authority
- GR
- Greece
- Prior art keywords
- tumors
- novel
- human
- antibodies against
- new antigen
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 210000004881 tumor cell Anatomy 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 210000001215 vagina Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ένα νέο μονοκλωνικό αντίσωμα που ενώνεται ισχυρά με πρωτεϊνικό αντιγόνο συνδεόμενο με αν?ρώπινους όγκους συμπεριλαμβανομένων καρκινωμάτων --------- - του κόλπου και των πνευμόνων. Το αντίσωμα ενώνεται με φυσιολογικά αν?ρώπινα κύτταρα σε πολύ μικρότερο βα?μό σε σχέση με ογκικά κύτταρα. Το αντίσωμα χρησιμοποείται και σε διαγνωστικές με?όδους όπως η ανίχνευση κακοή?ων κυττάρων που συνδέονται με όγκους και σε ?εραπευτικές με?όδους για τη ?εραπεία ασ?ενών με όγκο. Περιγράφεται επίσης ένα νέο γλυκοπρωτεϊνικό αντιγόνο M.B. 66.000 Daltons που ευρίσκεται στην κυτταρική επιφάνεια αν?ρώπινων ογκικών κυτττάρων. Η αμινοτερματική αλληλουχία αμινοξέων του αντιγόνου αυτού είναι: 1 5 10 15 20 X-E-L-T-I-L-H-T-N-D-V-H-S-R-L-E-Q-T-S-X όπου το Χ παριστάνει ένα μη ταυτοποιημένο αμινοξύ. ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/339,142 US5171665A (en) | 1989-04-17 | 1989-04-17 | Monoclonal antibody to novel antigen associated with human tumors |
Publications (2)
Publication Number | Publication Date |
---|---|
GR900100221A GR900100221A (en) | 1991-09-27 |
GR1000477B true GR1000477B (el) | 1992-07-30 |
Family
ID=23327694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR900100221A GR1000477B (el) | 1989-04-17 | 1990-03-23 | Νεο μονοκλωνικο αντισωμα κατα νεου αντιγονου που σχετιζεται με ανθρωπινους ογκους. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5171665A (el) |
EP (1) | EP0597829A1 (el) |
JP (1) | JPH04505102A (el) |
KR (1) | KR920700692A (el) |
AU (1) | AU639458B2 (el) |
CA (1) | CA2014304A1 (el) |
FI (1) | FI914908A0 (el) |
GR (1) | GR1000477B (el) |
IL (1) | IL93840A (el) |
NZ (1) | NZ233325A (el) |
PT (1) | PT93776A (el) |
WO (1) | WO1990012594A1 (el) |
Families Citing this family (111)
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US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
US7820180B2 (en) | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
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US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4713352A (en) * | 1981-08-31 | 1987-12-15 | Sloan-Kettering Institute For Cancer Reseach | Monoclonal antibody panel for early diagnosis and therapy of renal carcinoma |
US4612282A (en) * | 1981-12-15 | 1986-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Monoclonal antibodies reactive with human breast cancer |
US4507391A (en) * | 1982-04-02 | 1985-03-26 | Sloan-Kettering Institute For Cancer Research | Method for detecting the presence of GD3 ganglioside |
US4713351A (en) * | 1983-01-28 | 1987-12-15 | The University Of Rochester | Monoclonal antibody directed to an antigen derived from human ovarian tumors and a radioimmunoassay using the antibody |
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
ZA858371B (en) * | 1984-11-02 | 1987-03-25 | Oncogen | Monoclonal antibodies for human non-small cell lung carcinomas |
IL76877A (en) * | 1984-11-02 | 1991-11-21 | Oncogen | Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies |
US4708930A (en) * | 1984-11-09 | 1987-11-24 | Coulter Corporation | Monoclonal antibody to a human carcinoma tumor associated antigen |
US4906562A (en) * | 1984-12-21 | 1990-03-06 | Oncogen | Monocolonal antibodies and antigen for human non-small cell lung carcinomas |
US4935495A (en) * | 1984-12-21 | 1990-06-19 | Oncogen | Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5185432A (en) * | 1986-02-26 | 1993-02-09 | Oncogen | Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas |
EP0323802A3 (en) * | 1987-12-24 | 1989-07-26 | Sandoz Ag | Monoclonal antibodies against, and cell surface antigen of, lung carcinoma |
DE3809236A1 (de) * | 1988-03-18 | 1989-09-28 | Lohmann Therapie Syst Lts | Verwendung von ketogruppenhaltigen zyklischen verbindungen |
US5171666A (en) * | 1988-04-22 | 1992-12-15 | Eli Lilly And Company | Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas |
US5134075A (en) * | 1989-02-17 | 1992-07-28 | Oncogen Limited Partnership | Monoclonal antibody to novel antigen associated with human tumors |
GB8925900D0 (en) * | 1989-11-16 | 1990-01-04 | Ici Plc | Reactive dyes |
-
1989
- 1989-04-17 US US07/339,142 patent/US5171665A/en not_active Expired - Lifetime
-
1990
- 1990-03-22 IL IL9384090A patent/IL93840A/en not_active IP Right Cessation
- 1990-03-23 GR GR900100221A patent/GR1000477B/el unknown
- 1990-03-26 KR KR1019910701368A patent/KR920700692A/ko not_active Application Discontinuation
- 1990-03-26 EP EP90908763A patent/EP0597829A1/en not_active Withdrawn
- 1990-03-26 AU AU56714/90A patent/AU639458B2/en not_active Ceased
- 1990-03-26 WO PCT/US1990/001621 patent/WO1990012594A1/en not_active Application Discontinuation
- 1990-03-26 JP JP2508122A patent/JPH04505102A/ja active Pending
- 1990-04-10 CA CA002014304A patent/CA2014304A1/en not_active Abandoned
- 1990-04-12 NZ NZ233325A patent/NZ233325A/en unknown
- 1990-04-16 PT PT93776A patent/PT93776A/pt not_active Application Discontinuation
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1991
- 1991-10-17 FI FI914908A patent/FI914908A0/fi not_active Application Discontinuation
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GR900100221A (en) | 1991-09-27 |
NZ233325A (en) | 1992-04-28 |
KR920700692A (ko) | 1992-08-10 |
US5171665A (en) | 1992-12-15 |
AU639458B2 (en) | 1993-07-29 |
IL93840A (en) | 1995-07-31 |
EP0597829A4 (en) | 1992-02-27 |
PT93776A (pt) | 1991-02-08 |
FI914908A0 (fi) | 1991-10-17 |
AU5671490A (en) | 1990-11-16 |
EP0597829A1 (en) | 1994-05-25 |
CA2014304A1 (en) | 1990-10-17 |
JPH04505102A (ja) | 1992-09-10 |
IL93840A0 (en) | 1990-12-23 |
WO1990012594A1 (en) | 1990-11-01 |
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