GR1000321B - Ανασυνδυασμενες διαλυτες πρωτεινες για την μεταβολη της ορμονικ σ εκκρισεως. - Google Patents

Ανασυνδυασμενες διαλυτες πρωτεινες για την μεταβολη της ορμονικ σ εκκρισεως.

Info

Publication number
GR1000321B
GR1000321B GR890100540A GR890100540A GR1000321B GR 1000321 B GR1000321 B GR 1000321B GR 890100540 A GR890100540 A GR 890100540A GR 890100540 A GR890100540 A GR 890100540A GR 1000321 B GR1000321 B GR 1000321B
Authority
GR
Greece
Prior art keywords
gene encodes
hybrid particle
antigenic
particle immunogens
immunogens
Prior art date
Application number
GR890100540A
Other languages
English (en)
Other versions
GR890100540A (en
Inventor
C Scott Chappel
P Noreen Nugent
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of GR890100540A publication Critical patent/GR890100540A/el
Publication of GR1000321B publication Critical patent/GR1000321B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Μία ανασυνδυασμένη διαλυτή πρωτεϊνη που παράγεται από την έκφραση δύο γονιδίων, που ρυθμίζονται από έναν απλό προαγωγό, που έχει σαν αποτέλεσμα να μεταβάλει την ορμονική έκκριση, όταν διοχετεύεται σε μία θεραπευτική αποτελεσματική δόση. Ενα γονίδιο κωδικοποιεί την παραγωγή μιας ισχυρά αντιγονικής, υδροφιλικής πρωτεϊνης, όπως το επιφανειακό αντιγόνο της ηπατίτιδος Β, και το άλλο γονίδιο κωδικοποιεί ένα πεπτίδιο, το οποίο μόνο του δεν είναι ουσιαστικά αντιγονικό, όπως η ορμόνη απελευθερώνουσα την ωχρινοποιητική ορμόνη.ω
GR890100540A 1988-08-30 1989-08-30 Ανασυνδυασμενες διαλυτες πρωτεινες για την μεταβολη της ορμονικ σ εκκρισεως. GR1000321B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24655888A 1988-08-30 1988-08-30

Publications (2)

Publication Number Publication Date
GR890100540A GR890100540A (en) 1990-08-22
GR1000321B true GR1000321B (el) 1992-06-25

Family

ID=22931196

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100540A GR1000321B (el) 1988-08-30 1989-08-30 Ανασυνδυασμενες διαλυτες πρωτεινες για την μεταβολη της ορμονικ σ εκκρισεως.

Country Status (9)

Country Link
EP (1) EP0396653A1 (el)
JP (1) JPH03502584A (el)
AU (1) AU629237B2 (el)
DK (1) DK106590A (el)
FI (1) FI902151A0 (el)
GR (1) GR1000321B (el)
IL (1) IL91462A0 (el)
WO (1) WO1990002187A1 (el)
ZA (1) ZA896628B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
GB9101550D0 (en) * 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
JPH05339295A (ja) * 1991-12-05 1993-12-21 Agency Of Ind Science & Technol 抗体の作成方法
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
DE60017211T2 (de) * 1999-02-17 2005-06-02 Pfizer Products Inc., Groton Fusionsproteine mit Trägern welche eine doppelte Immunantwort induzieren
AU2001259452A1 (en) 2000-05-05 2001-11-20 Aphton Corporation Chimeric peptide immunogens their preparation and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963691A (en) * 1974-10-07 1976-06-15 Merck & Co., Inc. Synthetic antigens of luteinizing hormone releasing hormone
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
ATE70308T1 (de) * 1984-09-12 1991-12-15 Chiron Corp Hybridpartikel-immunogene.
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
WO1986007383A1 (en) * 1985-06-04 1986-12-18 Biotechnology Research Partners, Ltd. Autoantigen vaccines
GB8525615D0 (en) * 1985-10-17 1985-11-20 Hoffmann La Roche Polypeptides

Also Published As

Publication number Publication date
AU4076189A (en) 1990-03-23
ZA896628B (en) 1991-04-24
WO1990002187A1 (en) 1990-03-08
FI902151A0 (fi) 1990-04-27
JPH03502584A (ja) 1991-06-13
GR890100540A (en) 1990-08-22
IL91462A0 (en) 1990-04-29
DK106590D0 (da) 1990-04-30
DK106590A (da) 1990-04-30
AU629237B2 (en) 1992-10-01
EP0396653A1 (en) 1990-11-14

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