GEP20146006B - Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide - Google Patents

Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide

Info

Publication number
GEP20146006B
GEP20146006B GEAP201012498A GEAP2010012498A GEP20146006B GE P20146006 B GEP20146006 B GE P20146006B GE AP201012498 A GEAP201012498 A GE AP201012498A GE AP2010012498 A GEAP2010012498 A GE AP2010012498A GE P20146006 B GEP20146006 B GE P20146006B
Authority
GE
Georgia
Prior art keywords
dimethyl
butyramide
phenyl
morpholin
stable forms
Prior art date
Application number
GEAP201012498A
Other languages
English (en)
Inventor
De Diego Heidi Lopez
Karin Liltorp
Svend Treppendahl
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42237259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP20146006(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of GEP20146006B publication Critical patent/GEP20146006B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GEAP201012498A 2009-05-11 2010-05-11 Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide GEP20146006B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200900597 2009-05-11

Publications (1)

Publication Number Publication Date
GEP20146006B true GEP20146006B (en) 2014-01-10

Family

ID=42237259

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201012498A GEP20146006B (en) 2009-05-11 2010-05-11 Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide

Country Status (23)

Country Link
EP (1) EP2430008A2 (de)
JP (1) JP2012526152A (de)
KR (1) KR20120022934A (de)
CN (1) CN102459208A (de)
AR (1) AR076556A1 (de)
AU (1) AU2010246724B2 (de)
BR (1) BRPI1013930A2 (de)
CA (1) CA2761383A1 (de)
CL (1) CL2011002814A1 (de)
CO (1) CO6460741A2 (de)
CR (1) CR20110590A (de)
DO (1) DOP2011000351A (de)
EA (1) EA201171381A1 (de)
GE (1) GEP20146006B (de)
IL (1) IL216148A0 (de)
MA (1) MA33351B1 (de)
MX (1) MX2011011885A (de)
NZ (1) NZ596738A (de)
SG (1) SG175968A1 (de)
TN (1) TN2011000557A1 (de)
TW (1) TW201041857A (de)
WO (1) WO2010130260A2 (de)
ZA (1) ZA201108112B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119490430A (zh) 2019-08-02 2025-02-21 H.隆德贝克有限公司 用于在癫痫或癫痫发作中使用的作为Kv7钾通道开放剂的醇衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI349666B (en) * 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
BRPI0716715B1 (pt) * 2006-08-23 2021-07-06 Xenon Pharmaceuticals, Inc Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
EP2185149A1 (de) * 2007-08-01 2010-05-19 H. Lundbeck A/S Verwendung von kncq-kaliumkanal-öffnern zur verringerung von symptomen oder zur behandlung von erkrankungen oder störungen mit unterbrechung des dopaminergen systems

Also Published As

Publication number Publication date
SG175968A1 (en) 2011-12-29
IL216148A0 (en) 2012-01-31
MA33351B1 (fr) 2012-06-01
TW201041857A (en) 2010-12-01
BRPI1013930A2 (pt) 2019-09-24
CA2761383A1 (en) 2010-11-18
NZ596738A (en) 2013-04-26
CN102459208A (zh) 2012-05-16
EP2430008A2 (de) 2012-03-21
WO2010130260A2 (en) 2010-11-18
JP2012526152A (ja) 2012-10-25
MX2011011885A (es) 2011-12-06
TN2011000557A1 (en) 2013-05-24
CO6460741A2 (es) 2012-06-15
AR076556A1 (es) 2011-06-22
KR20120022934A (ko) 2012-03-12
CL2011002814A1 (es) 2012-04-13
WO2010130260A3 (en) 2011-06-16
AU2010246724A1 (en) 2011-12-08
EA201171381A1 (ru) 2012-05-30
CR20110590A (es) 2012-02-22
WO2010130260A9 (en) 2012-10-18
ZA201108112B (en) 2013-01-30
DOP2011000351A (es) 2012-01-31
AU2010246724B2 (en) 2013-03-21

Similar Documents

Publication Publication Date Title
PL3795573T3 (pl) Niektóre triazolopirazyny, ich kompozycje i sposoby ich zastosowania
MX339878B (es) Nuevas formas solidas de clorhidrato de bendamustina.
EP2437602A4 (de) Ophthalmische formulierungen, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung
IL238395B (en) Soluble attachment components of human serum, preparations and methods for their production
MX2011010012A (es) NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS.
GEP20146114B (en) New crystalline form vi of agomelatine, preparation method and application thereof
MX341825B (es) Compuestos de heteroarilo y usos de los mismos.
PH12012501306A1 (en) Oral care compositions
IL211541A0 (en) Co-crystal compositions, methods of producing the same and uses thereof
IL222930B (en) Chlorotoxin variants, conjugates and methods for their use
PH12013500500A1 (en) Fused heteroaryls and their uses
IL220343B (en) Polymer and protein conjugates and their use to create cross-linked structures
PL3461503T3 (pl) Sposoby podawania tetrahydrobiopteryny, związane z nią kompozycie i sposoby pomiaru
EP2638096A4 (de) Polyketaladdukte sowie herstellungsverfahren und verwendungsverfahren dafür
IL214754A0 (en) Compositions , synthesis, and methods of utilizing arylpiperazine derivatives
MY161868A (en) Anti-bv8 antibodies and uses thereof
WO2011086584A3 (en) Improved process for the preparation of amide intermediates and their use thereof
BRPI0920995A2 (pt) catalisador de metal carregado e método de preparação do mesmo.
MX336742B (es) Inhibidores de amida hidrolasa de acido graso.
MY151100A (en) Salts of n-[6-cis-2, 6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy)[1,1?-biphenyl]-3-carboxamide
GB201210536D0 (en) Composition, use and method of preparation thereof
EP2296675A4 (de) Aus echinoderm gewonnene extrakte, herstellungsverfahren und ihre verwendungen
WO2010111421A3 (en) Isoform nell-1 peptide
ZA201108112B (en) Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide
GEP20207101B (en) ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF β-AMINO-α- HYDROXY AMIDES