GB988526A - Diazabicyclooctanes - Google Patents

Diazabicyclooctanes

Info

Publication number
GB988526A
GB988526A GB2315762A GB2315762A GB988526A GB 988526 A GB988526 A GB 988526A GB 2315762 A GB2315762 A GB 2315762A GB 2315762 A GB2315762 A GB 2315762A GB 988526 A GB988526 A GB 988526A
Authority
GB
United Kingdom
Prior art keywords
acyl
alkyl
general formula
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2315762A
Inventor
Giorgio Cignarella
Emilio Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Priority to GB2315762A priority Critical patent/GB988526A/en
Priority to DK253963A priority patent/DK122524B/en
Priority to ES288611A priority patent/ES288611A1/en
Priority to BE633541A priority patent/BE633541A/en
Priority to SE655663A priority patent/SE329169B/xx
Priority to CH742063A priority patent/CH435306A/en
Priority to AT481063A priority patent/AT245575B/en
Priority to CH1677166A priority patent/CH470398A/en
Priority to DE19631595909 priority patent/DE1595909B2/en
Priority to FI122163A priority patent/FI46256C/en
Publication of GB988526A publication Critical patent/GB988526A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises a process for the preparation of compounds of general formula <FORM:0988526/C2/1> wherein either R or R1 represents an acyl radical and the other represents, hydrogen, alkyl, aryl, aralkyl, cycloallyl-alkyl (the alkyl portion contains 1 to 8 carbon atoms), or an aralkenyl optionally substituted by alkyl, alkoxy, nitro or chloro, by subjecting a compound of general formula <FORM:0988526/C2/2> wherein X is an acyl radical to debenzylation by catalytic hydrogenation under pressure, optionally submitting the product to rearrangement of the acyl group from N8 to N3, the action of an acidic or basic catalyst, for example by (a) heating to between 60 DEG and 140 DEG C. for 5 to 8 hours, (b) by refluxing in an alkanol water solution with hydrochloric acid, or (c) treating in an alkanol water solution at room temperature with an alkali metal hydroxide, and the resulting compound of formula <FORM:0988526/C2/3> wherein either X or Y is acyl and the other is hydrogen, is reacted with a compound of formula R halogen, where R has the above meaning other than acyl. N8 - Acyl - 3 - benzyl - 3,8 - diazabicyclo-[3,2,1]-octanes of the second general formula above are prepared by acylating 3-benzyl-3,8-diazabicyclo-[3,2,1]-octane. Specifications 937,183 and 949,088 are referred to.
GB2315762A 1962-06-15 1962-06-15 Diazabicyclooctanes Expired GB988526A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB2315762A GB988526A (en) 1962-06-15 1962-06-15 Diazabicyclooctanes
DK253963A DK122524B (en) 1962-06-15 1963-05-29 Process for the preparation of 3,8-diazabicyclo- (3,2,1) -octanes.
ES288611A ES288611A1 (en) 1962-06-15 1963-05-31 Procedure for preparation of 3,8-diazabiciclo- (3,2,1) -octanos (Machine-translation by Google Translate, not legally binding)
BE633541A BE633541A (en) 1962-06-15 1963-06-12 Diazabicyclo-octanes
SE655663A SE329169B (en) 1962-06-15 1963-06-13
CH742063A CH435306A (en) 1962-06-15 1963-06-14 Process for preparing diazabicyclo-octanes
AT481063A AT245575B (en) 1962-06-15 1963-06-14 Process for the preparation of new 3,8-diazabicyclo- [3,2,1] -octanes
CH1677166A CH470398A (en) 1962-06-15 1963-06-14 Process for preparing diazabicyclo-octanes
DE19631595909 DE1595909B2 (en) 1962-06-15 1963-06-14 3,8-Diazabicyclo square bracket to 3,2,1 square bracket to octane and a process for their preparation. Eliminated from: 1243689
FI122163A FI46256C (en) 1962-06-15 1963-06-15 Method for the preparation of 3,8-diazabicyclo [3.2.1] octanes.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2315762A GB988526A (en) 1962-06-15 1962-06-15 Diazabicyclooctanes

Publications (1)

Publication Number Publication Date
GB988526A true GB988526A (en) 1965-04-07

Family

ID=10191086

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2315762A Expired GB988526A (en) 1962-06-15 1962-06-15 Diazabicyclooctanes

Country Status (9)

Country Link
AT (1) AT245575B (en)
BE (1) BE633541A (en)
CH (1) CH435306A (en)
DE (1) DE1595909B2 (en)
DK (1) DK122524B (en)
ES (1) ES288611A1 (en)
FI (1) FI46256C (en)
GB (1) GB988526A (en)
SE (1) SE329169B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521776A (en) 2004-11-30 2008-06-26 ノイロサーチ アクティーゼルスカブ Novel diazabicyclic aryl derivatives as cholinergic ligands

Also Published As

Publication number Publication date
FI46256B (en) 1972-10-31
BE633541A (en) 1963-10-21
DE1595909B2 (en) 1974-07-04
SE329169B (en) 1970-10-05
DE1595909A1 (en) 1970-02-26
FI46256C (en) 1973-02-12
ES288611A1 (en) 1963-11-01
CH435306A (en) 1967-05-15
AT245575B (en) 1966-03-10
DK122524B (en) 1972-03-13

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