GB986644A - Novel derivatives of salicylic acid and preparations thereof - Google Patents
Novel derivatives of salicylic acid and preparations thereofInfo
- Publication number
- GB986644A GB986644A GB1420662A GB1420662A GB986644A GB 986644 A GB986644 A GB 986644A GB 1420662 A GB1420662 A GB 1420662A GB 1420662 A GB1420662 A GB 1420662A GB 986644 A GB986644 A GB 986644A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- formula
- salicylic acid
- solvent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000004885 piperazines Chemical class 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 abstract 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE630639D BE630639A (enrdf_load_stackoverflow) | 1962-04-12 | ||
| GB1420662A GB986644A (en) | 1962-04-12 | 1962-04-12 | Novel derivatives of salicylic acid and preparations thereof |
| CH415463A CH421971A (fr) | 1962-04-12 | 1963-04-02 | Préparation de nouveaux dérivés de l'acide salicylique |
| DK170563A DK103300C (da) | 1962-04-12 | 1963-04-10 | Fremgangsmåde til fremstilling af N-benzylpiperazinderivater eller deres syreadditionssalte. |
| ES286931A ES286931A1 (es) | 1962-04-12 | 1963-04-10 | Procedimiento de preparación de nuevos derivados del ácido salicílico |
| DK525063A DK105028C (da) | 1962-04-12 | 1963-04-10 | Fremgangsmåde til fremstilling N-benzyl-piperazinderivater eller syreadditionssalte heraf. |
| BR14839863A BR6348398D0 (pt) | 1962-04-12 | 1963-04-10 | Preparacao de novos derivados do acido salicilico |
| FR931508A FR1355173A (fr) | 1962-04-12 | 1963-04-12 | Préparation de nouveaux dérivés de l'acide salicylique |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1420662A GB986644A (en) | 1962-04-12 | 1962-04-12 | Novel derivatives of salicylic acid and preparations thereof |
| GB3018062 | 1962-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB986644A true GB986644A (en) | 1965-03-17 |
Family
ID=26250389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1420662A Expired GB986644A (en) | 1962-04-12 | 1962-04-12 | Novel derivatives of salicylic acid and preparations thereof |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE630639A (enrdf_load_stackoverflow) |
| BR (1) | BR6348398D0 (enrdf_load_stackoverflow) |
| CH (1) | CH421971A (enrdf_load_stackoverflow) |
| DK (2) | DK105028C (enrdf_load_stackoverflow) |
| ES (1) | ES286931A1 (enrdf_load_stackoverflow) |
| FR (1) | FR1355173A (enrdf_load_stackoverflow) |
| GB (1) | GB986644A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189033A (en) * | 1990-10-08 | 1993-02-23 | Imperial Chemical Industries Plc | Tricyclic heterocycles |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1351946A2 (en) | 2000-09-01 | 2003-10-15 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| JP2006523681A (ja) | 2003-03-24 | 2006-10-19 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | Ｄｎａ−ｐｋ阻害剤としてのキサントン、チオキサントンおよびアクリジノン |
-
0
- BE BE630639D patent/BE630639A/xx unknown
-
1962
- 1962-04-12 GB GB1420662A patent/GB986644A/en not_active Expired
-
1963
- 1963-04-02 CH CH415463A patent/CH421971A/fr unknown
- 1963-04-10 ES ES286931A patent/ES286931A1/es not_active Expired
- 1963-04-10 DK DK525063A patent/DK105028C/da active
- 1963-04-10 BR BR14839863A patent/BR6348398D0/pt unknown
- 1963-04-10 DK DK170563A patent/DK103300C/da active
- 1963-04-12 FR FR931508A patent/FR1355173A/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189033A (en) * | 1990-10-08 | 1993-02-23 | Imperial Chemical Industries Plc | Tricyclic heterocycles |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1355173A (fr) | 1964-03-13 |
| BE630639A (enrdf_load_stackoverflow) | |
| DK105028C (da) | 1966-08-08 |
| CH421971A (fr) | 1966-10-15 |
| DK103300C (da) | 1965-12-13 |
| ES286931A1 (es) | 1963-07-01 |
| BR6348398D0 (pt) | 1973-06-12 |
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