GB968410A - Fluorescent compositions for the internal examination of animals - Google Patents
Fluorescent compositions for the internal examination of animalsInfo
- Publication number
- GB968410A GB968410A GB19342/61A GB1934261A GB968410A GB 968410 A GB968410 A GB 968410A GB 19342/61 A GB19342/61 A GB 19342/61A GB 1934261 A GB1934261 A GB 1934261A GB 968410 A GB968410 A GB 968410A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- compound
- aryl group
- animals
- fluorescent compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 241001465754 Metazoa Species 0.000 title abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 3
- 239000007850 fluorescent dye Substances 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000962 organic group Chemical group 0.000 abstract 2
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 abstract 2
- -1 2,4 - di - anilino, 1,3,5 - triazinyl Chemical group 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005027 hydroxyaryl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 235000010603 pastilles Nutrition 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 1
- 239000011118 polyvinyl acetate Substances 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000021286 stilbenes Nutrition 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Optics & Photonics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A composition for use in the internal examination of animals particularly humans either living or dead comprises at least one fluorescent compound which absorbs ultra-violet radiation in the range of from 3000 to 3800 Angstroms, re-emits in the range of from 4000 to 5500 Angstroms and contains a carbon-carbon double bond adjacent to at least one aryl group, said aryl group containing, as substituents, one or more carboxylic acid or sulphonic acid groups, or a salt of such a compound, together with a carrier or diluent. The salt may be an alkali metal or ammonium salt or a salt formed from the group \sLN, R1, R2, R3, R4, wherein R1 is alkyl, aryl, hydroxyalkyl or hydroxyaryl and R2, R3 and R4 represent hydrogen or any of the groups representable by R1. The fluorescent compound may be a compound of formula <FORM:0968410/C4-C5/1> wherein R5 is an organic group attached to the nitrogen via a carbon atom, e.g. -COR10, wherein R10 represents an aryl group or <FORM:0968410/C4-C5/2> in which R6, R7, R8 and R9 represents hydrogen or organic groups. For administration to living animals, 1 to 13% of the fluorescent compound in a parenteral solvent such as water. The compositions may also be used as aqueous solutions buffered at pH 7.0. Other carriers are polyvinyl acetate, diethylene glycol and monoethanolamine. They may be administered in the form of cakes, pastilles, tablets, pills, capsules, dragees and other oral preparations; rectal preparations and parental preparations. They may be introduced into the hollow organs and excretory and secretory passages. The examination of the fluorescence produced by the compositions of the invention can be carried out visually, microscopically, photographically or photometrically. Specific examples, in general, are of stilbene derivatives, e.g. 2,21-disulphonic - 4,41 - bis(2,4 - di - anilino, 1,3,5 - triazinyl, 6-amino)stilbene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR828335A FR1265968A (en) | 1960-05-27 | 1960-05-27 | New method of examining the vascular system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB968410A true GB968410A (en) | 1964-09-02 |
Family
ID=8732239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19342/61A Expired GB968410A (en) | 1960-05-27 | 1961-05-29 | Fluorescent compositions for the internal examination of animals |
Country Status (2)
| Country | Link |
|---|---|
| FR (2) | FR1265968A (en) |
| GB (1) | GB968410A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2000403A1 (en) * | 1968-01-18 | 1969-09-05 | Sumitomo Chemical Co |
-
1960
- 1960-05-27 FR FR828335A patent/FR1265968A/en not_active Expired
- 1960-07-13 FR FR832863A patent/FR670M/fr active Active
-
1961
- 1961-05-29 GB GB19342/61A patent/GB968410A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2000403A1 (en) * | 1968-01-18 | 1969-09-05 | Sumitomo Chemical Co |
Also Published As
| Publication number | Publication date |
|---|---|
| FR670M (en) | 1961-07-17 |
| FR1265968A (en) | 1961-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES388803A1 (en) | Fibre-reactive dyestuffs | |
| DE3177205D1 (en) | INDUSTRIAL COMPOUNDS APPLICABLE AS INTERMEDIATE PRODUCTS IN THE PRODUCTION OF 4-HYDROXY 3-QUINOLINCARBOXAMIDE DERIVATIVES SUBSTITUTED IN POSITION 2 AND THE PRODUCTION OF THESE INTERIM PRODUCTS. | |
| GB925429A (en) | Indole derivatives | |
| GB1111989A (en) | 2',3'-dideoxyriboside-2',3'-olefins | |
| ES438138A1 (en) | Thioxanthone carboxylic acids and derivatives | |
| GB968410A (en) | Fluorescent compositions for the internal examination of animals | |
| ATE16278T1 (en) | HYDROXYBENZYLAMINO-ARYL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS. | |
| ES390163A1 (en) | Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding) | |
| ES448629A1 (en) | Benzoxazole derivatives, process for their preparation and their use as optical brighteners | |
| GB858792A (en) | New pyridazine derivatives and processes for their manufacture | |
| GB1008849A (en) | Basically substituted triazolidines, processes for their manufacture and pharmaceutical preparations containing them | |
| CH608785A5 (en) | Process for producing new N-acylglutamines | |
| ATE14120T1 (en) | SULFIMINE, THEIR SALTS AND THEIR PRODUCTION, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS. | |
| GB986644A (en) | Novel derivatives of salicylic acid and preparations thereof | |
| ES392355A1 (en) | D-homosteroid imides and a process for the preparation thereof | |
| CH614940A5 (en) | Process for the preparation of new terpenoaromatic amidines | |
| GB2010824A (en) | 4-amino-6,7-dialkoxy-2- substituted quinazolines | |
| ES396174A1 (en) | Phenylethanolamine derivatives | |
| ES393554A1 (en) | Thiazole derivatives and a process for the manufacture thereof | |
| ES397246A1 (en) | Procedure for the obtaining of diazepine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| GB1412663A (en) | 2- 4-biphenylyl- tetrahydrofurans and pharmaceutical compositions containing them | |
| GB1004927A (en) | Improvements in or relating to amino-ketones, their preparation and compositions containing them | |
| GB1109959A (en) | Dioxolan, oxathiolan and dithiolan derivatives | |
| ES389292A1 (en) | Process for the manufacture of optically active bicycloalkane derivatives | |
| GB1036278A (en) | Piperidine derivatives |