ES397246A1 - Procedure for the obtaining of diazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining diazepine derivatives of general formula I **(See formula)** wherein R1 represents hydrogen or an alkyl group with 1 to 3 carbon atoms, R2 means the hydroxyl group, an alkoxy or alkanoyloxy group, in each case with 1 to 6 carbon atoms, a mono- or diarylmethoxy group, a group 2-oxacycloalkoxy with 5 to 7 ring members or a fluorine atom and A means an alkylene group with 1 to 3 carbon atoms, and rings B and C may be substituted by halogen of atomic number up to 35, trifluoromethyl groups, alkyl or alkoxy with 1 to 6 carbon atoms, as well as the 5-oxides of the compounds of general formula I and the addition salts of the compounds of general formula I and their 5-oxides with inorganic and organic acids, characterized in that a compound of general formula II **(See formula)** wherein X stands for the mercapto group, a lower alkoxy or alkylthio group which is optionally activated by a substituent, or an amino group, in each case given mono- or disubstituted, R1 has the meaning indicated in formula I and rings B and C, may be substituted as indicated under formula I, condensed with a compound of general formula III R'2 - A - CO - NH - NH2 (III) in which R'2 has the meaning indicated in formula I for R2, with the exception of alkanoyloxy groups with 1 to 6 carbon atoms, and A has the meaning indicated in formula I and, optionally, a product of the process obtained, whose residue R'2 is a monoarylmethoxy or diarylmethoxy group, or a 2-oxacycloalkoxy group, is cleaved to a compound of general formula I, whose residue R2 is the hydroxyl group, and/or if desired, a product of the process, whose residue R'2 is the hydroxyl group, is acylated to a compound of general formula I whose residue R2 is an alkanoyloxy group with 1 to 6 carbon atoms, and/or, if desired, a product of the obtained process is oxidized its 5-oxide and/or if desired a reaction product obtained is transformed into an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)