GB976532A - Sulphonamides - Google Patents

Sulphonamides

Info

Publication number
GB976532A
GB976532A GB1170261A GB1170261A GB976532A GB 976532 A GB976532 A GB 976532A GB 1170261 A GB1170261 A GB 1170261A GB 1170261 A GB1170261 A GB 1170261A GB 976532 A GB976532 A GB 976532A
Authority
GB
United Kingdom
Prior art keywords
sulphamoyl
fluoro
benzoyl chloride
acid
converting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1170261A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH569360A external-priority patent/CH393325A/en
Priority claimed from CH1390460A external-priority patent/CH409975A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB976532A publication Critical patent/GB976532A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises sulphonamides of the formula <FORM:0976532/C1/1> and their acid addition salts, wherein A is a methylene or ethylene group and B is a nitrogen, oxygen or sulphur containing heterocyclic group attached to A through one of its carbon atoms, and the preparation of these compounds by reacting a 3-sulphamoyl-4-halo-benzoyl chloride with a carbinol B-A-OH and converting to a salt such as the hydrochloride, hydrobromide, sulphate, citrate, oxalate, tartrate, succinate, maleate, acetate, benzoate, hexahydrobenzoate, methanesulphanate, fumarate, gallate or hydroiodide, if desired. Examples describe tetra-hydrofuryl-, tetrahydropyranyl-, pyridyl-(21, 31 and 41)-, quinolyl-(21 and 41)- and thienyl -(21)-methyl esters and the 11-methyl-piperidyl-(21)-ethyl esters of the 3-sulphamoyl-4-chloro (and 4-fluoro)-benzoic acids. 3-Sulphamoyl-4-fluoro-benzoyl chloride used as a starting material is made by treating 4-fluorobenzoic acid with chlorosulphonic acid, treating the resulting 3-chlorosulphonyl-4-fluoro-benzoic acid with ammonia to give the corresponding 3-sulphamoyl compound and converting to the benzoyl chloride by reaction with thionyl chloride Pharmaceutical preparation having diuretic and saliuretic activity comprise the above compounds of the invention in admixture with an inert carrier.
GB1170261A 1960-05-18 1961-03-30 Sulphonamides Expired GB976532A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH569360A CH393325A (en) 1960-05-18 1960-05-18 Process for the preparation of sulfonamides
CH1002360 1960-09-05
CH1390460A CH409975A (en) 1960-05-18 1960-12-13 Process for the preparation of sulfonamides
CH141861 1961-02-07

Publications (1)

Publication Number Publication Date
GB976532A true GB976532A (en) 1964-11-25

Family

ID=27428178

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1170261A Expired GB976532A (en) 1960-05-18 1961-03-30 Sulphonamides

Country Status (2)

Country Link
ES (1) ES267411A1 (en)
GB (1) GB976532A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531488A (en) * 1966-05-12 1970-09-29 Bayer Ag Disulphonamides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531488A (en) * 1966-05-12 1970-09-29 Bayer Ag Disulphonamides

Also Published As

Publication number Publication date
ES267411A1 (en) 1961-11-16

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