GB975379A - Preparation of ª‡-aminobenzylpenicillin and salts thereof - Google Patents

Preparation of ª‡-aminobenzylpenicillin and salts thereof

Info

Publication number
GB975379A
GB975379A GB3179162A GB3179162A GB975379A GB 975379 A GB975379 A GB 975379A GB 3179162 A GB3179162 A GB 3179162A GB 3179162 A GB3179162 A GB 3179162A GB 975379 A GB975379 A GB 975379A
Authority
GB
United Kingdom
Prior art keywords
salts
aminobenzylpenicillin
toxic salt
preparation
ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3179162A
Inventor
Maurice John Soulal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB3179162A priority Critical patent/GB975379A/en
Priority to ES0290518A priority patent/ES290518A1/en
Priority to BR15132163A priority patent/BR6351321D0/en
Priority to CH976963A priority patent/CH419134A/en
Priority to DK382963A priority patent/DK104060C/en
Priority to SE901263A priority patent/SE324776B/xx
Publication of GB975379A publication Critical patent/GB975379A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a -Aminobenzylpenicillin, or a non-toxic salt thereof, is produced by reacting a -bromobenzylpenicillin, or a non-toxic salt thereof, with hexamethylene tetramine. Specified salts are the sodium, potassium, calcium, aluminium, ammonium and substituted ammonium salts, e.g. salts of triethylamine procaine, dibenzylamine, N-benzyl-beta-phenethylamine, lephenamine, N,N1-dibenzylethylenediamine, dehydroabietylamine and N,N1-bis-dehydroabietylethylenediamine. The a -aminobenzylpenicillin is an antibacterial agent for human and animal use, e.g. mastitis in cattle, and is a nutritional supplement in animal feeds. Specifications 873,049 and 880,042 are referred to
GB3179162A 1962-08-18 1962-08-18 Preparation of ª‡-aminobenzylpenicillin and salts thereof Expired GB975379A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB3179162A GB975379A (en) 1962-08-18 1962-08-18 Preparation of ª‡-aminobenzylpenicillin and salts thereof
ES0290518A ES290518A1 (en) 1962-08-18 1963-08-01 Preparation of -aminobenzylpenicillin and salts thereof
BR15132163A BR6351321D0 (en) 1962-08-18 1963-08-01 AMINOBENZYLPENICILLIN PREPARATION PROCESS
CH976963A CH419134A (en) 1962-08-18 1963-08-07 Process for the preparation of α-amino-benzylpenicillin and non-toxic salts thereof
DK382963A DK104060C (en) 1962-08-18 1963-08-09 Process for the preparation of α-aminobenzylpenicillin or salts thereof.
SE901263A SE324776B (en) 1962-08-18 1963-08-16

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3179162A GB975379A (en) 1962-08-18 1962-08-18 Preparation of ª‡-aminobenzylpenicillin and salts thereof

Publications (1)

Publication Number Publication Date
GB975379A true GB975379A (en) 1964-11-18

Family

ID=10328458

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3179162A Expired GB975379A (en) 1962-08-18 1962-08-18 Preparation of ª‡-aminobenzylpenicillin and salts thereof

Country Status (6)

Country Link
BR (1) BR6351321D0 (en)
CH (1) CH419134A (en)
DK (1) DK104060C (en)
ES (1) ES290518A1 (en)
GB (1) GB975379A (en)
SE (1) SE324776B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB873049A (en) * 1958-10-06 1961-07-19 Beecham Res Lab Improvements in or relating to penicillin derivatives

Also Published As

Publication number Publication date
DK104060C (en) 1966-03-28
ES290518A1 (en) 1963-10-16
SE324776B (en) 1970-06-15
CH419134A (en) 1966-08-31
BR6351321D0 (en) 1973-07-17

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