GB972003A - New imidazolidine compounds - Google Patents
New imidazolidine compoundsInfo
- Publication number
- GB972003A GB972003A GB42088/62A GB4208862A GB972003A GB 972003 A GB972003 A GB 972003A GB 42088/62 A GB42088/62 A GB 42088/62A GB 4208862 A GB4208862 A GB 4208862A GB 972003 A GB972003 A GB 972003A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- alkyl
- group
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:0972003/C1/1> wherein R1 is a phenyl, aralkyl, or halogen-, the halogenated alkyl-, acyl-, alkyl- or alkoxy-substituted phenyl or aralkyl radical, R2 and R3, which may be the same or different, are hydrogen atoms or alkyl or aryl radicals, R4 and R5, which may be the same or different, are alkyl radicals or may be alkylene radicals linked either directly or through an oxygen, sulphur or nitrogen atom, the nitrogen atom having attached thereto an alkyl or hydroxyalkyl radical, Y is a branched or unbranched alkylene radical, and X is an oxygen or sulphur atom or an imino-group, and acid addition salts thereof. These compounds may be prepared by (1) converting a compound of formula <FORM:0972003/C1/2> to its alkali metal salt and reacting this with a compound of formula <FORM:0972003/C1/3> wherein Z is the residue of an organic or inorganic acid and R6 and R7 have the same values as R4 and R5 with the exception of alkylene groups linked through an N-hydroxyalkyl group, (2) reacting compounds of formula <FORM:0972003/C1/4> wherein V is a reactive substituent, for example a chlorine atom, with an amine of formula HNR4R5, (3) catalytic hydrogenation of a compound of formula <FORM:0972003/C1/5> wherein X1 is an oxygen atom or an imino group and Y1 is an alkylene group having one carbon atom less than the desired group Y, in the presence of an amine of formula HNR6R7, or by catalytic hydrogenation to the primary amine followed by alkylation, or (4) cyclization of compounds of formula <FORM:0972003/C1/6> by reaction with carbonic acid dialkyl esters, chloroformic acid esters, cyanogen halides, phosgene, thiophosgene, carbon disulphide or cyanic acid. The compounds of the invention have analgesic, cataleptic and anti-emetic properties.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0035302 | 1961-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB972003A true GB972003A (en) | 1964-10-07 |
Family
ID=7095946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42088/62A Expired GB972003A (en) | 1961-11-07 | 1962-11-07 | New imidazolidine compounds |
Country Status (4)
| Country | Link |
|---|---|
| AT (3) | AT245568B (en) |
| CH (4) | CH427827A (en) |
| FR (1) | FR2288M (en) |
| GB (1) | GB972003A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459757A (en) * | 1965-10-22 | 1969-08-05 | American Cyanamid Co | Imidazolidines |
| US3728355A (en) * | 1970-09-21 | 1973-04-17 | Monsanto Co | 3-carbocyclic-5,5-dialkyl-2-imidazolidinethiones |
| US4988723A (en) * | 1988-06-02 | 1991-01-29 | Fujisawa Pharmaceutical Co., Ltd. | Benzopyran derivatives and their use as anti-hypertensives |
| WO2022129020A1 (en) | 2020-12-16 | 2022-06-23 | Nouryon Chemicals International B.V. | Manufacture of nitrile compounds |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19822678A1 (en) * | 1998-05-20 | 1999-11-25 | Bayer Ag | New 1,3-diaza-2-oxo-cycloalkane derivatives, useful as pre- or post-emergence, total or selective herbicides |
-
1962
- 1962-10-31 CH CH1637066A patent/CH427827A/en unknown
- 1962-10-31 CH CH1637166A patent/CH427828A/en unknown
- 1962-10-31 CH CH1636966A patent/CH427826A/en unknown
- 1962-10-31 CH CH1278262A patent/CH426850A/en unknown
- 1962-11-07 GB GB42088/62A patent/GB972003A/en not_active Expired
- 1962-11-07 AT AT669463A patent/AT245568B/en active
- 1962-11-07 AT AT669363A patent/AT245567B/en active
- 1962-11-07 AT AT669563A patent/AT244957B/en active
-
1963
- 1963-01-25 FR FR922701A patent/FR2288M/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459757A (en) * | 1965-10-22 | 1969-08-05 | American Cyanamid Co | Imidazolidines |
| US3728355A (en) * | 1970-09-21 | 1973-04-17 | Monsanto Co | 3-carbocyclic-5,5-dialkyl-2-imidazolidinethiones |
| US4988723A (en) * | 1988-06-02 | 1991-01-29 | Fujisawa Pharmaceutical Co., Ltd. | Benzopyran derivatives and their use as anti-hypertensives |
| WO2022129020A1 (en) | 2020-12-16 | 2022-06-23 | Nouryon Chemicals International B.V. | Manufacture of nitrile compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2288M (en) | 1964-01-20 |
| CH427828A (en) | 1967-01-15 |
| AT245568B (en) | 1966-03-10 |
| CH426850A (en) | 1966-12-31 |
| CH427827A (en) | 1967-01-15 |
| CH427826A (en) | 1967-01-15 |
| AT245567B (en) | 1966-03-10 |
| AT244957B (en) | 1966-02-10 |
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