GB967492A - 4-(5-nitro-2-furyl)thiazoles - Google Patents
4-(5-nitro-2-furyl)thiazolesInfo
- Publication number
- GB967492A GB967492A GB3451/60A GB345160A GB967492A GB 967492 A GB967492 A GB 967492A GB 3451/60 A GB3451/60 A GB 3451/60A GB 345160 A GB345160 A GB 345160A GB 967492 A GB967492 A GB 967492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- general formula
- furyl
- prepared
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0967492/C1/1> (wherein R1 represents a hydrogen atom or an alkyl radical, and R2 represents a dialkylamino, pyridylamino, guanidino, phenyl or dialkyl-aminophenyl radical, or a 2-, 3- or 4- pyridyl radical, optionally substituted by one or two alkyl radicals, or by a halogen atom or by a hydroxy radical and an alkyl radical) and acid addition and quaternary salts thereof, and their preparation by (a) reacting a compound of the general formula: <FORM:0967492/C1/2> (wherein Y represents a halogen atom) with a compound of the general formula R2.CS.NHR3 (wherein R3 represents a hydrogen atom or a C1-5 alkyl radical), or (b) reacting a compound of the general formula: <FORM:0967492/C1/3> or an acid addition or quaternary salt thereof, with an acyl nitrate and treating the resulting intermediate with a base, optionally followed in either case by conversion to an acid addition or quaternary salt where such a salt is not obtained directly. 5-Nitro -2- furyl chloromethyl ketone is prepared by treating an etheral solution of 5-nitro -2- furyl diazomethyl ketone with dry hydrogen chloride. 2,6-Dimethylthionicotinamide is prepared by saturating a solution of 3-cyano-2, 6-dimethylpyridine in ethanolic ammonia with hydrogen sulphide. 4,6-Dimethylthionicotinamide and 2-hydroxy -6- methylthionicotinamide are prepared similarly. 4-(2-Furyl) -2- (3-pyridyl) thiazole is prepared by heating 2-chloroacetylfuran with thionicotinamide in ethanol. The compounds of the invention possess antibacterial and antiprotozoal activity. According to the Provisional Specification, R2 may represent an amino, hydrocarbon or heterocyclic radical, which may optionally be substituted.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE599556D BE599556A (en) | 1960-02-01 | ||
GB3451/60A GB967492A (en) | 1960-02-01 | 1960-02-01 | 4-(5-nitro-2-furyl)thiazoles |
US83385A US3074954A (en) | 1960-02-01 | 1961-01-18 | Heterocyclic compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3451/60A GB967492A (en) | 1960-02-01 | 1960-02-01 | 4-(5-nitro-2-furyl)thiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
GB967492A true GB967492A (en) | 1964-08-26 |
Family
ID=9758579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3451/60A Expired GB967492A (en) | 1960-02-01 | 1960-02-01 | 4-(5-nitro-2-furyl)thiazoles |
Country Status (3)
Country | Link |
---|---|
US (1) | US3074954A (en) |
BE (1) | BE599556A (en) |
GB (1) | GB967492A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298743A (en) * | 1979-09-11 | 1981-11-03 | Merck & Co., Inc. | 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones |
US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2481673A (en) * | 1945-03-01 | 1949-09-13 | Eastman Kodak Co | 2-amino-and 2-alkylthio-4-(2-furyl)-thiazoles |
US2992225A (en) * | 1959-09-14 | 1961-07-11 | Abbott Lab | Certain 4-(5-nitro-2-furyl)-thiazoles |
-
0
- BE BE599556D patent/BE599556A/xx unknown
-
1960
- 1960-02-01 GB GB3451/60A patent/GB967492A/en not_active Expired
-
1961
- 1961-01-18 US US83385A patent/US3074954A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US3074954A (en) | 1963-01-22 |
BE599556A (en) |
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