GB965352A - Production of a callikrein inactivator from insulin wastes - Google Patents
Production of a callikrein inactivator from insulin wastesInfo
- Publication number
- GB965352A GB965352A GB4609862A GB4609862A GB965352A GB 965352 A GB965352 A GB 965352A GB 4609862 A GB4609862 A GB 4609862A GB 4609862 A GB4609862 A GB 4609862A GB 965352 A GB965352 A GB 965352A
- Authority
- GB
- United Kingdom
- Prior art keywords
- callikrein
- inactivator
- insulin
- precipitating
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000937 inactivator Effects 0.000 title abstract 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 239000002699 waste material Substances 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 230000001376 precipitating effect Effects 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- ZNPFTBFMCCMMJJ-UHFFFAOYSA-N 2-hydroxy-3,5-disulfobenzoic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1O ZNPFTBFMCCMMJJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 229910021380 Manganese Chloride Inorganic materials 0.000 abstract 1
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 210000001557 animal structure Anatomy 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000011565 manganese chloride Substances 0.000 abstract 1
- 235000002867 manganese chloride Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 229940062190 pancreas extract Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF35630A DE1161658B (de) | 1961-12-22 | 1961-12-22 | Gewinnung des Kallikrein-Inaktivators aus Insulin-Abfaellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB965352A true GB965352A (en) | 1964-07-29 |
Family
ID=7096079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4609862A Expired GB965352A (en) | 1961-12-22 | 1962-12-06 | Production of a callikrein inactivator from insulin wastes |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH449850A (enrdf_load_stackoverflow) |
| DE (1) | DE1161658B (enrdf_load_stackoverflow) |
| DK (1) | DK103411C (enrdf_load_stackoverflow) |
| FR (1) | FR1345316A (enrdf_load_stackoverflow) |
| GB (1) | GB965352A (enrdf_load_stackoverflow) |
| NL (1) | NL287049A (enrdf_load_stackoverflow) |
| SE (1) | SE323170B (enrdf_load_stackoverflow) |
-
0
- NL NL287049D patent/NL287049A/xx unknown
-
1961
- 1961-12-22 DE DEF35630A patent/DE1161658B/de active Pending
-
1962
- 1962-11-20 CH CH1357162A patent/CH449850A/de unknown
- 1962-12-06 GB GB4609862A patent/GB965352A/en not_active Expired
- 1962-12-20 DK DK556762A patent/DK103411C/da active
- 1962-12-21 SE SE13893/62A patent/SE323170B/xx unknown
- 1962-12-21 FR FR919513A patent/FR1345316A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE323170B (enrdf_load_stackoverflow) | 1970-04-27 |
| CH449850A (de) | 1968-01-15 |
| FR1345316A (fr) | 1963-12-06 |
| NL287049A (enrdf_load_stackoverflow) | |
| DE1161658B (de) | 1964-01-23 |
| DK103411C (da) | 1965-12-27 |
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