GB960167A - Improvements in or relating to diagnostic compositions - Google Patents

Improvements in or relating to diagnostic compositions

Info

Publication number
GB960167A
GB960167A GB30938/61A GB3093861A GB960167A GB 960167 A GB960167 A GB 960167A GB 30938/61 A GB30938/61 A GB 30938/61A GB 3093861 A GB3093861 A GB 3093861A GB 960167 A GB960167 A GB 960167A
Authority
GB
United Kingdom
Prior art keywords
composition
glucose
oxidation
hydrogen peroxide
dihydroxybenzaldazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30938/61A
Inventor
William Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Priority to US218868A priority Critical patent/US3233974A/en
Publication of GB960167A publication Critical patent/GB960167A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/30—2,2'-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid), i.e. ABTS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A composition for detecting glucose in urine comprises glucose oxidase, an oxidation-catalyst, and an indicator which is oxidized by hydrogen peroxide, changes colour on oxidation and has the general formula AR-X-AR wherein Ar is a phenyl group which may have one or more hydroxy and methoxy substituents and X is the radical -(CH=CH)m-CH=(N-N)n=CH-(CH=CH)p-in which m, n and p are each each to 0 or to 1, and a catalyst for causing the oxidation of the indicator by hydrogen peroxide. The glucose oxidase converts glucose to gluoconic acid in the presence of atmospheric oxygen and at the same time forms hydrogen peroxide. Suitable indicators are 4,41-dihydroxystilbene, 4,41-dihydroxybenzaldazine, vanillinazine, 3,31,5,51-tetramethoxy-4, 41-dihydroxybenzaldazine, 3,31-dimethoxy-4,41-dihydroxystilbene, and bis-gamma(4-hydroxyphenyl)acroleinazine. Splinters, sticks or strips of wood, paper or cellulose acetate may be impregnated with the composition; or the composition may be applied to glass, metal or plastic using gelatin as adhesive. Such test pieces will change colour when moistened with a glucose-containing liquid. Suitable catalysts are peroxidase, catalase, blood, hemin, uroferriporphrin chloride, and a mixture of potassium iodide and sodium molybdate. A buffer composition, e.g. citric acid/sodium citrate may be added to the test composition in order to keep the pH of the reactants at a predetermined value. Gelatine, dog plasma, bovine albumin, egg albumin and casein may be incorporated in the compositions. Specification 808,742 is referred to.
GB30938/61A 1961-08-28 1961-08-28 Improvements in or relating to diagnostic compositions Expired GB960167A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US218868A US3233974A (en) 1961-08-28 1962-08-23 Diagnostic compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2149470A 1970-03-20 1970-03-20

Publications (1)

Publication Number Publication Date
GB960167A true GB960167A (en) 1964-06-10

Family

ID=21804551

Family Applications (2)

Application Number Title Priority Date Filing Date
GB30938/61A Expired GB960167A (en) 1961-08-28 1961-08-28 Improvements in or relating to diagnostic compositions
GB16914/64A Expired GB1068533A (en) 1970-03-20 1964-04-23 Improvements relating to glucose testing

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB16914/64A Expired GB1068533A (en) 1970-03-20 1964-04-23 Improvements relating to glucose testing

Country Status (2)

Country Link
US (1) US3627698A (en)
GB (2) GB960167A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247845A1 (en) * 1986-05-30 1987-12-02 EASTMAN KODAK COMPANY (a New Jersey corporation) Use of methine dyes for the determination of hydrogen peroxide or analytes producing same

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7208092A (en) * 1972-06-14 1973-12-18
US3926732A (en) * 1973-02-16 1975-12-16 Alfa Laval Ab Method for assaying catalase in milk and other liquids
CS175782B1 (en) * 1974-10-16 1977-05-31
US4175923A (en) * 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
US4247297A (en) * 1979-02-23 1981-01-27 Miles Laboratories, Inc. Test means and method for interference resistant determination of oxidizing substances
US4344439A (en) * 1980-10-20 1982-08-17 Ulrico Jacobellis Catheter for use in localizing the origin of idiopathic microscopic hematuria
US4956300A (en) * 1982-01-05 1990-09-11 Helena Laboratories Corporation Aid for determining the presence of occult blood, method of making the aid, and method of using the aid
US5702913A (en) * 1983-12-21 1997-12-30 Helena Laboratories Corporation Chromgen-reagent test system
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US4615982A (en) * 1984-12-11 1986-10-07 Lawrence Paul J Fecal occult blood test
EP0477999A1 (en) * 1984-12-11 1992-04-01 LAWRENCE, Paul J. Fecal occult blood test reagent and methods
US4818702A (en) * 1986-06-02 1989-04-04 Litmus Concepts, Inc. Fecal occult blood test reagent
US5081040A (en) * 1987-06-29 1992-01-14 Helena Laboratories Corporation Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes
US5183751A (en) * 1988-04-20 1993-02-02 Maes Roland F Stabilization of peroxidase solutions by para-amino-salicyclic acid
US5217874A (en) * 1989-04-04 1993-06-08 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
GB9027131D0 (en) * 1990-12-14 1991-02-06 Rice Evans Catherine Diagnostic test
US6063631A (en) * 1997-05-21 2000-05-16 3M Innovative Properties Company Sterilization indicator
US6238623B1 (en) 1997-05-21 2001-05-29 3M Innovative Properties Company Labels and tracking systems for sterilization procedures
US6287518B1 (en) 1997-06-25 2001-09-11 3M Innovative Properties Company Sterilization monitors
US9034593B2 (en) 2010-11-22 2015-05-19 Kimberly-Clark Worldwide, Inc. Vaginal indicator to detect biomarkers of good health

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183173A (en) * 1963-06-10 1965-05-11 Miles Lab Test composition for detecting hydrogen peroxide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247845A1 (en) * 1986-05-30 1987-12-02 EASTMAN KODAK COMPANY (a New Jersey corporation) Use of methine dyes for the determination of hydrogen peroxide or analytes producing same

Also Published As

Publication number Publication date
US3627698A (en) 1971-12-14
GB1068533A (en) 1967-05-10

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