GB951559A - Newcastle disease vaccine and the preparation thereof - Google Patents
Newcastle disease vaccine and the preparation thereofInfo
- Publication number
- GB951559A GB951559A GB46315/61A GB4631561A GB951559A GB 951559 A GB951559 A GB 951559A GB 46315/61 A GB46315/61 A GB 46315/61A GB 4631561 A GB4631561 A GB 4631561A GB 951559 A GB951559 A GB 951559A
- Authority
- GB
- United Kingdom
- Prior art keywords
- calf
- kidney
- culture
- tissue culture
- kidney tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A vaccine comprises the Komarov KH strain of Newcastle disease virus cultivated on mammalian kidney tissue culture of one mammalian species, e.g. calf or more than one mammelian species, e.g. calf and pig. In general, more than one serial passage is used, e.g. 21 passages through calf kidney culture or 10 serial passages on calf kidney tissue culture followed by 11 serial passages on pig kidney tissue culture. Pieces of kidney are treated with a buffered saline solution of trypsin. The freed cells are suspended in Hank's solution, centrifuged and incubated in a nutrient medium comprising lactalbumin hydrolyate, yeast extract, calf serum, sodium penicillin and streptomycin sulphate in Hank's solution, at 37 DEG C. for 3 days, fresh nutrient medium added and incubation continued until a complete mono-layer developes. This is inoculated with KH strain of Newcastle disease virus in thick embryo allantoic fluid and diluted 1/100 with above nutrient fluid and incubated for three days at 37 DEG C. The culture is then frozen, thawed, shaken and centrifuged. The supernatant is inoculated into another kidney kidney tissue culture and the process repeated for the desired number of serial passages. The resultant culture fluid may be formulated into a vaccine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB46315/61A GB951559A (en) | 1961-12-27 | 1961-12-27 | Newcastle disease vaccine and the preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB46315/61A GB951559A (en) | 1961-12-27 | 1961-12-27 | Newcastle disease vaccine and the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB951559A true GB951559A (en) | 1964-03-04 |
Family
ID=10440743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46315/61A Expired GB951559A (en) | 1961-12-27 | 1961-12-27 | Newcastle disease vaccine and the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB951559A (en) |
-
1961
- 1961-12-27 GB GB46315/61A patent/GB951559A/en not_active Expired
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