GB948785A - Improvements in or relating to 1-phthalidyl-1.2.3.4-tetrahydroisoquinoline derivatives - Google Patents
Improvements in or relating to 1-phthalidyl-1.2.3.4-tetrahydroisoquinoline derivativesInfo
- Publication number
- GB948785A GB948785A GB2580160A GB2580160A GB948785A GB 948785 A GB948785 A GB 948785A GB 2580160 A GB2580160 A GB 2580160A GB 2580160 A GB2580160 A GB 2580160A GB 948785 A GB948785 A GB 948785A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phthalidyl
- residue
- acid
- hydroxyl group
- free hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 1-phthalidyl-1,2,3,4,-tetrahydroisoquinolines of the formula: <FORM:0948785/C2/1> and their acid addition salts wherein R represents an aryl radical substituted by one or more alkoxy radicals and if desired, by a hydroxyl radical or an N-containing heterocyclic radical of aromatic character and the preparation thereof by esterifying the corresponding 5-hydroxymethyl-tetra hydroisoquinoline with an acid halide or anhydride of an acid R.COOH. Where the residue R contains a free hydroxyl group (e.g. R.CO- is a syringoyl residue) the free hydroxyl group is protected as the ester and subsequently liberated. Pharmaceutical compositions comprise the compounds of the invention together with an inert carrier. The compositions depress the cough reflex and act on the central nervous system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7990159A CH376109A (en) | 1959-10-27 | 1959-10-27 | Process for the preparation of previously unknown isoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948785A true GB948785A (en) | 1964-02-05 |
Family
ID=4537503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2580160A Expired GB948785A (en) | 1959-10-27 | 1960-07-25 | Improvements in or relating to 1-phthalidyl-1.2.3.4-tetrahydroisoquinoline derivatives |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU254568B1 (en) |
| CH (1) | CH376109A (en) |
| ES (1) | ES261964A1 (en) |
| GB (1) | GB948785A (en) |
-
1959
- 1959-10-27 CH CH7990159A patent/CH376109A/en unknown
-
1960
- 1960-07-25 GB GB2580160A patent/GB948785A/en not_active Expired
- 1960-10-26 ES ES0261964A patent/ES261964A1/en not_active Expired
- 1960-10-26 AU AU65978/60A patent/AU254568B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU254568B1 (en) | 1962-11-01 |
| CH376109A (en) | 1964-03-31 |
| ES261964A1 (en) | 1961-05-16 |
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