GB942152A - Improvements in or relating to benzhydryl ethers - Google Patents

Improvements in or relating to benzhydryl ethers

Info

Publication number
GB942152A
GB942152A GB43068/60A GB4306860A GB942152A GB 942152 A GB942152 A GB 942152A GB 43068/60 A GB43068/60 A GB 43068/60A GB 4306860 A GB4306860 A GB 4306860A GB 942152 A GB942152 A GB 942152A
Authority
GB
United Kingdom
Prior art keywords
ethers
salts
chlorine
carbon atoms
bromine atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43068/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH53760A external-priority patent/CH382164A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB942152A publication Critical patent/GB942152A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

The invention comprises benzhydryl ethers (antihistaminics) of the general formula I, <FORM:0942152/C2/1> (wherein R1 represents a hydrogen, fluorine, chlorine or bromine atom, or an alkyl or alkoxy group containing from 1 to 3 carbon atoms, R2 represents an alkyl group containing from 1 to 4 carbon atoms, m is 0, 1, 2, or 3, n is 1 or 2 and m=n is at least 2), their acid addition salts (e.g. with hydrochloric, hydrobromic, sulphuric, citric, oxalic, tartaric, succinic, maleic acetic, benzoic, hexahydrobenzoic, fumaric, methanesulphonic and naphthalene -1,5- disulphonic acids), pharmaceutical compositions containing the ethers and/or their salts together with an inert carrier, and a process for preparing the ethers and salts by condensing a diphenyl-methyl compound (II) with a pyrrolidine or piperidine derivative (III): <FORM:0942152/C2/2> (wherein one of the two symbols X represents a hydroxyl group and the other represents a chlorine or bromine atom), optionally followed by salt formation.
GB43068/60A 1960-01-19 1960-12-14 Improvements in or relating to benzhydryl ethers Expired GB942152A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH53760A CH382164A (en) 1960-01-19 1960-01-19 Process for the production of new ethers
CH880760A CH389608A (en) 1960-01-19 1960-08-03 Process for the production of new ethers
CH1089760 1960-09-27

Publications (1)

Publication Number Publication Date
GB942152A true GB942152A (en) 1963-11-20

Family

ID=27172192

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43068/60A Expired GB942152A (en) 1960-01-19 1960-12-14 Improvements in or relating to benzhydryl ethers

Country Status (8)

Country Link
BR (1) BR6125965D0 (en)
CH (1) CH389608A (en)
CY (1) CY379A (en)
DE (1) DE1228262B (en)
ES (1) ES264077A1 (en)
FR (1) FR1279691A (en)
GB (1) GB942152A (en)
OA (1) OA00698A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5223068A (en) * 1975-08-13 1977-02-21 Nippon Kayaku Co Ltd Preparation of optically active 1-methyl -2-(2'-(alpha-methyl-p-chlorobenz hydryloxy) ethtyl) pyrrolidine fumarates
US8592397B2 (en) 2003-01-14 2013-11-26 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US8598185B2 (en) 2005-06-13 2013-12-03 Bristol-Myers Squibb & Gilead Sciences, Inc. Unitary pharmaceutical dosage form
US8871271B2 (en) 2005-06-13 2014-10-28 Gilead Sciences, Inc. Method and composition for pharmaceutical product
CN107011228A (en) * 2017-05-24 2017-08-04 浙江诚意药业股份有限公司 A kind of preparation method of clemastine fumarate

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307255A (en) * 1970-09-12 1973-02-14 Pfizer Ltd Substituted basic benzhydryl ethers
US4835164A (en) * 1987-02-20 1989-05-30 A. H. Robins Company, Incorporated Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE934890C (en) * 1951-10-07 1955-11-10 Chem Fab Promonta Ges Mit Besc Process for the preparation of basic benzhydryl ethers

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5223068A (en) * 1975-08-13 1977-02-21 Nippon Kayaku Co Ltd Preparation of optically active 1-methyl -2-(2'-(alpha-methyl-p-chlorobenz hydryloxy) ethtyl) pyrrolidine fumarates
US8592397B2 (en) 2003-01-14 2013-11-26 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US8716264B2 (en) 2003-01-14 2014-05-06 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US9457036B2 (en) 2003-01-14 2016-10-04 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US9744181B2 (en) 2003-01-14 2017-08-29 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US8598185B2 (en) 2005-06-13 2013-12-03 Bristol-Myers Squibb & Gilead Sciences, Inc. Unitary pharmaceutical dosage form
US8871271B2 (en) 2005-06-13 2014-10-28 Gilead Sciences, Inc. Method and composition for pharmaceutical product
US9018192B2 (en) 2005-06-13 2015-04-28 Bristol-Myers Squibb & Gilead Sciences, Inc. Unitary pharmaceutical dosage form
US9545414B2 (en) 2005-06-13 2017-01-17 Bristol-Myers Squibb & Gilead Sciences, Llc Unitary pharmaceutical dosage form
CN107011228A (en) * 2017-05-24 2017-08-04 浙江诚意药业股份有限公司 A kind of preparation method of clemastine fumarate
CN107011228B (en) * 2017-05-24 2019-08-09 浙江诚意药业股份有限公司 A kind of preparation method of clemastine fumarate

Also Published As

Publication number Publication date
DE1228262B (en) 1966-11-10
CY379A (en) 1967-03-04
BR6125965D0 (en) 1973-06-28
CH389608A (en) 1965-03-31
FR1279691A (en) 1961-12-22
ES264077A1 (en) 1961-07-16
OA00698A (en) 1967-07-15

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