GB936505A - New chemotherapeutically active pyridazine derivatives and method of preparing the same - Google Patents
New chemotherapeutically active pyridazine derivatives and method of preparing the sameInfo
- Publication number
- GB936505A GB936505A GB254561A GB254561A GB936505A GB 936505 A GB936505 A GB 936505A GB 254561 A GB254561 A GB 254561A GB 254561 A GB254561 A GB 254561A GB 936505 A GB936505 A GB 936505A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- preparing
- new
- same
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises sulpha-pyridazines of the formula <FORM:0936505/IV(a)/1> and salts thereof, wherein R is a C1-4 branched or unbranched alkyl group, e.g. CH3, C2H5, and their preparation by oxidising a 3-amino-6-alkylthiopyridazine, suitably by treating with 30% aqueous hydrogen peroxide at 60-80 DEG C., reacting the resulting 3-amino-6-alkylsulphinyl-pyridazine (e.g. the 6-methylsulphinyl or 6-ethylsulphinyl 3-amino-pyridazines) with a benzenesulphohalide X,C6H4,SO2,Hal, wherein X is an amino radical or a radical convertible to an amino group by hydrolysis, e.g. a carbethoxyamino group, in the presence of a hydrogen halide-binding agent, e.g. pyridine, at an elevated temperature, preferably at 75-85 DEG C., and if necessary converting the para-substituent, X, into an amino group.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS44760 | 1960-01-21 | ||
| CS639760 | 1960-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB936505A true GB936505A (en) | 1963-09-11 |
Family
ID=25745285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB254561A Expired GB936505A (en) | 1960-01-21 | 1961-01-23 | New chemotherapeutically active pyridazine derivatives and method of preparing the same |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH390262A (en) |
| GB (1) | GB936505A (en) |
-
1961
- 1961-01-18 CH CH57361A patent/CH390262A/en unknown
- 1961-01-23 GB GB254561A patent/GB936505A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH390262A (en) | 1965-04-15 |
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