GB911229A - Improvements in or relating to ataractic compositions - Google Patents

Improvements in or relating to ataractic compositions

Info

Publication number
GB911229A
GB911229A GB6764/61A GB676461A GB911229A GB 911229 A GB911229 A GB 911229A GB 6764/61 A GB6764/61 A GB 6764/61A GB 676461 A GB676461 A GB 676461A GB 911229 A GB911229 A GB 911229A
Authority
GB
United Kingdom
Prior art keywords
free base
methyl
pharmaceutically acceptable
formula
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6764/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB911229A publication Critical patent/GB911229A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pharmaceutical preparation for the treatment of depression comprises a phenylcyclopropylamine base, preferably in the transconfiguration, or a non-toxic pharmaceutically acceptable acid addition salt thereof, the free base heaving the formula <FORM:0911229/VI/1> in which R1 and R2 represent hydrogen or methyl groups, in admixture with a 10-(o -aminoalkyl) phenothiazine free base or a non-toxic pharmaceutically acceptable acid addition salt thereof, the free base having the formula <FORM:0911229/VI/2> in which X is hydrogen, chloro, trifluoromethyl, methyl, methoxy or methylthio; A represents propylene or 2-methyl propylene and Z is dimethylamino, methylpiperazinyl, hydroxyethylpiperazinyl, hydroxyethoxyethylpiperazinyl, acetoxyethyl piperazinyl or methylpiperidyl. The salts may be the nitrate, phosphate, citrate, acetate, lactate, mandelate, salicylate, tartrate, ethanedisulphonate, sulphamate, acetylsalicylate, succinate, fumarate, maleate, hydrobromate and benzoate. The preparation is preferably admixed with a solid or liquid pharmaceutical carrier and may take the form of a tablet, capsule, elixir, aqueous injection or dispersion in vegetable oils.
GB6764/61A 1960-03-07 1961-02-23 Improvements in or relating to ataractic compositions Expired GB911229A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12917A US3011945A (en) 1960-03-07 1960-03-07 Phenylcyclopropylamine -10-(omega-aminoalkyl)-phenothiazine ataractic composition

Publications (1)

Publication Number Publication Date
GB911229A true GB911229A (en) 1962-11-21

Family

ID=21757361

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6764/61A Expired GB911229A (en) 1960-03-07 1961-02-23 Improvements in or relating to ataractic compositions

Country Status (4)

Country Link
US (1) US3011945A (en)
BE (1) BE600835A (en)
FR (1) FR981M (en)
GB (1) GB911229A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3515785A (en) * 1958-12-06 1970-06-02 Geigy Chem Corp Compositions and methods for treating endogenous depression with 3-chloro - 5 - (gamma - dimethylamino - propyl)-iminodibenzyl
NL273148A (en) * 1961-01-07
US3134676A (en) * 1961-06-21 1964-05-26 Smith Kline French Lab Animal feed compositions and methods for their administration
BE626236A (en) * 1961-12-18
GB1027611A (en) * 1962-01-04 1966-04-27 May & Baker Ltd Phenoxy- and phenylthio-alkylamines and acid addition salts thereof
US3192229A (en) * 1962-07-03 1965-06-29 Colgate Palmolive Co Phenylcyclopropyl amides
US3192207A (en) * 1963-03-11 1965-06-29 Robins Co Inc A H Aminoalkyl esters of 4-carboxyalkyl-2-pyrrolidinones and 4-carboxyalkyl-2-thionpyrrolidinones
US3621097A (en) * 1970-03-30 1971-11-16 Jan Marcel Didier Aron Samuel Method and compositions for treatment of mental illness
US4444789A (en) * 1980-05-30 1984-04-24 University Of Georgia Research Foundation, Inc. Use of 8-anilino-1-naphthalenesulfonate as a vaginal contraceptive
JP6980534B2 (en) 2015-06-25 2021-12-15 ザ チルドレンズ メディカル センター コーポレーション Methods and Compositions for Enlargement, Enrichment, and Maintenance of Hematopoietic Stem Cells
AU2017235461B2 (en) 2016-03-15 2023-02-23 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion

Also Published As

Publication number Publication date
US3011945A (en) 1961-12-05
FR981M (en) 1961-12-04
BE600835A (en) 1961-09-04

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