GB886778A - Diagnostic composition - Google Patents
Diagnostic compositionInfo
- Publication number
- GB886778A GB886778A GB10679/60A GB1067960A GB886778A GB 886778 A GB886778 A GB 886778A GB 10679/60 A GB10679/60 A GB 10679/60A GB 1067960 A GB1067960 A GB 1067960A GB 886778 A GB886778 A GB 886778A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- hemin
- aminobenzthiazole
- pyridine
- nicotinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Compositions for detecting glucose comprise (a) glucose oxidase, (b) a metalloporphyrin, (c) a heterocyclic compound containing a ring nitrogen atom singly and doubly bonded to two carbon atoms and (d) a colour-forming substance oxidisable by hydrogen peroxide in the presence of (b) and (c). Specified metalloporphyrins (b) are hemin and metalloprophyrins in which the metal atom is Fe, Co, Ni, Mn, Mg, Cu, Zn or a complex such as VO. Specified heterocyclic compounds (c) are 2-aminobenzthiazole, pyridine, bipyridyl, bipyridyl-pyridine and nicotinic acid. Specified colour-forming substances (d) are 2:7-diaminofluorene, o-tolidine and leucoindophenols. Protective agents, wetting agents, a background dye and buffering mixtures (preferred pH is 3-7) may also be present in the composition, and the composition is prepared by separately preparing solutions of (a) and (d) and of (b) and (c) and thereafter impregnating a bibulous material with the first mentioned solution, drying, impregnating with the second solution and using wet or subsequently drying. In one example, only one end of a strip was impregnated with the diagnostic composition, the remainder having a water-impervious barrier of ethyl cellulose. In examples, the following combinations were employed: (1) first solution: aqueous algin, citrate buffer, gelatine, red substituted xanthone dye, 2:7-diaminofluorene dihydrochloride (in aqueous ethanol) and glucose oxidase (catalase present being destroyed by heating); second solution: hemin and 2-aminobenzthiazole in aqueous ethanol containing polyvinyl alcohol (wetting and stabilizing agent), (2) first solution: citrate buffer, gelatine, o-tolidine dihydrochloride (in ethanol) and glucose oxidase; second solution: hemin dissolved in pyridine and diluted with ethanol, (3) first solution as (2); second solution: hemin, nicotinic acid or 2-aminobenzthiazole in aqueous ethanol containing polyvinyl alcohol, (4) first solution as (1); second solution as (3), using nicotinic acid. Specifications 575,612, 784,548 and 808,742 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US802281A US3042496A (en) | 1959-03-27 | 1959-03-27 | Diagnostic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB886778A true GB886778A (en) | 1962-01-10 |
Family
ID=25183293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10679/60A Expired GB886778A (en) | 1959-03-27 | 1960-03-25 | Diagnostic composition |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3042496A (en) |
| DE (1) | DE1185841B (en) |
| GB (1) | GB886778A (en) |
| NL (1) | NL102893C (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL277911A (en) * | 1961-05-04 | |||
| NL288096A (en) * | 1962-01-24 | |||
| US3278394A (en) * | 1963-07-22 | 1966-10-11 | Miles Lab | Method and composition for diagnosing glucose |
| DE1260827B (en) * | 1964-12-09 | 1968-02-08 | Miles Lab | Preparation for the detection of glucose in urine |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| US4560534A (en) * | 1983-11-02 | 1985-12-24 | Miles Laboratories, Inc. | Polymer catalyst transducers |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| JPS60162957A (en) * | 1984-02-03 | 1985-08-24 | Kyowa Medetsukusu Kk | Method for measuring ceruloplasmin activity |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
-
0
- NL NL102893D patent/NL102893C/xx active
-
1959
- 1959-03-27 US US802281A patent/US3042496A/en not_active Expired - Lifetime
-
1960
- 1960-03-19 DE DEM44720A patent/DE1185841B/en active Pending
- 1960-03-25 GB GB10679/60A patent/GB886778A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1185841B (en) | 1965-01-21 |
| US3042496A (en) | 1962-07-03 |
| NL102893C (en) |
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