WO1993002652A3 - Modified haptens useful as imaging and therapeutic agents - Google Patents

Modified haptens useful as imaging and therapeutic agents Download PDF

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Publication number
WO1993002652A3
WO1993002652A3 PCT/US1992/006360 US9206360W WO9302652A3 WO 1993002652 A3 WO1993002652 A3 WO 1993002652A3 US 9206360 W US9206360 W US 9206360W WO 9302652 A3 WO9302652 A3 WO 9302652A3
Authority
WO
WIPO (PCT)
Prior art keywords
imaging
therapeutic agents
degradation
aqueous solution
modified
Prior art date
Application number
PCT/US1992/006360
Other languages
French (fr)
Other versions
WO1993002652A2 (en
Inventor
Pavanasam N Balasubramanian
Charles P Lollo
Philip M Wanek
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of WO1993002652A2 publication Critical patent/WO1993002652A2/en
Publication of WO1993002652A3 publication Critical patent/WO1993002652A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

The present invention discloses a method for preserving a chemical compound associated with or attached to a strong beta emitter in an aqueous solution from radiolytic degradation by adding thereto a reducing oxidizing agent, preferably ascorbate ion, as a radioprotectant. For instance, degradation of haptens radiolabelled with a strong beta emitter, such as 90Yttrium, and stored in an aqueous solution can be substantially reduced by adding ascorbate ion to the solution. A method for preventing radiolytic degradation of compounds during the radiolabelling process is also provided.
PCT/US1992/006360 1991-08-01 1992-07-31 Modified haptens useful as imaging and therapeutic agents WO1993002652A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73962091A 1991-08-01 1991-08-01
US739,620 1991-08-01

Publications (2)

Publication Number Publication Date
WO1993002652A2 WO1993002652A2 (en) 1993-02-18
WO1993002652A3 true WO1993002652A3 (en) 1993-03-18

Family

ID=24973112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/006360 WO1993002652A2 (en) 1991-08-01 1992-07-31 Modified haptens useful as imaging and therapeutic agents

Country Status (2)

Country Link
AU (1) AU2541592A (en)
WO (1) WO1993002652A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314678A (en) * 1992-01-28 1994-05-24 Mallinckrodt Medical, Inc. Sodium iodide 131 I capsules
FR2727687B1 (en) * 1994-12-02 1997-01-24 Isotopchim Sarl STABILIZATION OF RADIOMARKED COMPOUNDS
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
US5961955A (en) 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
EP1808184A3 (en) * 2000-10-24 2008-08-13 CIS bio international Stabilisation of radiopharmaceutical compositions using a hydrophilic thioether or a hydrophilic 6-hydroxy chroman
KR20080022108A (en) * 2005-06-14 2008-03-10 니혼 메디피직스 가부시키가이샤 Radioactive diagnostic imaging agent
US20110112291A1 (en) * 2007-11-30 2011-05-12 Eva Hoess Stabilization of conjugates comprising a thiourea linker
ES2624637T3 (en) * 2008-05-30 2017-07-17 Atotech Deutschland Gmbh Electrogalvanoplasty additive for the deposition of an alloy of a metal of group IB / binary or ternary of group IB-group IIIA / ternary, quaternary or quinary of group IB, group IIIA-group VIA

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2309216A1 (en) * 1975-04-30 1976-11-26 Procter & Gamble STABLE RADIOGRAPHIC EXPLORATION AGENTS
FR2309215A1 (en) * 1975-04-30 1976-11-26 Hoffmann La Roche STABLE DIAGNOSTIC REAGENTS SUITABLE TO BE TRANSFORMED INTO RADIOMEDICINES
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
EP0217577A2 (en) * 1985-09-12 1987-04-08 Hybritech Incorporated Antibody complexes of hapten-modified diagnostic or therapeutic agents
WO1991004057A1 (en) * 1989-09-22 1991-04-04 Neorx Corporation Stable therapeutic radionuclide compositions and methods for preparation thereof
US5093105A (en) * 1991-04-09 1992-03-03 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416865A (en) * 1973-02-20 1983-11-22 Research Corporation Radiopharmaceuticals for localization of thromboembolic disease
FR2309216A1 (en) * 1975-04-30 1976-11-26 Procter & Gamble STABLE RADIOGRAPHIC EXPLORATION AGENTS
FR2309215A1 (en) * 1975-04-30 1976-11-26 Hoffmann La Roche STABLE DIAGNOSTIC REAGENTS SUITABLE TO BE TRANSFORMED INTO RADIOMEDICINES
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
EP0217577A2 (en) * 1985-09-12 1987-04-08 Hybritech Incorporated Antibody complexes of hapten-modified diagnostic or therapeutic agents
WO1991004057A1 (en) * 1989-09-22 1991-04-04 Neorx Corporation Stable therapeutic radionuclide compositions and methods for preparation thereof
US5093105A (en) * 1991-04-09 1992-03-03 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 111, 1989, Columbus, Ohio, US; abstract no. 53305, *

Also Published As

Publication number Publication date
AU2541592A (en) 1993-03-02
WO1993002652A2 (en) 1993-02-18

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