GB880201A - 16ª--ú¼17ª--substituted pregnatrienes and derivatives thereof - Google Patents
16ª--ú¼17ª--substituted pregnatrienes and derivatives thereofInfo
- Publication number
- GB880201A GB880201A GB21978/59A GB2197859A GB880201A GB 880201 A GB880201 A GB 880201A GB 21978/59 A GB21978/59 A GB 21978/59A GB 2197859 A GB2197859 A GB 2197859A GB 880201 A GB880201 A GB 880201A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pregnadiene
- dione
- substituted
- steroid
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 16a ,17a -substituted steroids having the formula <FORM:0880201/IV (b)/1> in which R is a hydrogen atom or a lower alkanoyl radical containing 1-6 carbon atoms and =C9-C11- is <FORM:0880201/IV (b)/2> and a method for the preparation thereof which comprises (a) hydrolysing the corresponding 16a ,17a -isoalkylidenedioxy steroid, (b) and, if desired, alkanoylating to form the corresponding 16a -alkanoyloxy steroid. Hydrolysis may be effected with a mineral acid. Illustrative products of the invention are 9a -fluoro-11b , 16a ,17a -trihydroxy-1,4-pregnadiene-3,20-dione, 9a -chloro - 11b ,16a ,17a - trichydroxy - 1,4 - pregnadiene - 3,20 - dione, 16a - acetoxy - 17a - hydroxy - 1,4,9(11) - pregnatriene - 3,20 - dione, and 9a - fluoro - 16a ,17a - dihydroxy - 1,4 - pregnadiene - 3,11,20-trione.ALSO:Pharmaceutical compositions comprise a compound of the formula <FORM:0880201/VI/1> wherein R is H or a lower alkanoyl radical containing 1-6 carbon atoms and =C9-C11 is =C=CH-, <FORM:0880201/VI/2> and a pharmaceutical diluent. They are employed as tablets, powders and pills.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US880201XA | 1958-07-09 | 1958-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB880201A true GB880201A (en) | 1961-10-18 |
Family
ID=22208736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB21978/59A Expired GB880201A (en) | 1958-07-09 | 1959-06-26 | 16ª--ú¼17ª--substituted pregnatrienes and derivatives thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB880201A (en) |
-
1959
- 1959-06-26 GB GB21978/59A patent/GB880201A/en not_active Expired
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