GB875845A - Improvements in or relating to phenthiazine derivatives - Google Patents
Improvements in or relating to phenthiazine derivativesInfo
- Publication number
- GB875845A GB875845A GB12506/59A GB1250659A GB875845A GB 875845 A GB875845 A GB 875845A GB 12506/59 A GB12506/59 A GB 12506/59A GB 1250659 A GB1250659 A GB 1250659A GB 875845 A GB875845 A GB 875845A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- phenthiazine
- general formula
- prepared
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical class C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 title abstract 6
- -1 cyano, dimethylsulphamoyl Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 150000003053 piperidines Chemical class 0.000 abstract 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 2
- DNBWGFKLIBQQSL-UHFFFAOYSA-N n-methyl-1-pyridin-4-ylmethanamine Chemical compound CNCC1=CC=NC=C1 DNBWGFKLIBQQSL-UHFFFAOYSA-N 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- RGEQSTMITLEXKD-UHFFFAOYSA-N 1-benzyl-n-methylpiperidin-4-amine Chemical compound C1CC(NC)CCN1CC1=CC=CC=C1 RGEQSTMITLEXKD-UHFFFAOYSA-N 0.000 abstract 1
- YUBDLZGUSSWQSS-UHFFFAOYSA-N 1-benzylpiperidin-4-amine Chemical class C1CC(N)CCN1CC1=CC=CC=C1 YUBDLZGUSSWQSS-UHFFFAOYSA-N 0.000 abstract 1
- SJZKULRDWHPHGG-UHFFFAOYSA-N 1-benzylpiperidin-4-one Chemical compound C1CC(=O)CCN1CC1=CC=CC=C1 SJZKULRDWHPHGG-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 208000010513 Stupor Diseases 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 229940125683 antiemetic agent Drugs 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 238000006264 debenzylation reaction Methods 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical class OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000002688 maleic acid derivatives Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UGQXPTUMTGDBJJ-UHFFFAOYSA-N n-methyl-n-piperidin-4-ylacetamide Chemical compound CC(=O)N(C)C1CCNCC1 UGQXPTUMTGDBJJ-UHFFFAOYSA-N 0.000 abstract 1
- HAFXGJMDMTXZBI-UHFFFAOYSA-N n-methyl-n-piperidin-4-ylmorpholine-4-carboxamide Chemical compound C1COCCN1C(=O)N(C)C1CCNCC1 HAFXGJMDMTXZBI-UHFFFAOYSA-N 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- BGUWFUQJCDRPTL-UHFFFAOYSA-N pyridine-4-carbaldehyde Chemical compound O=CC1=CC=NC=C1 BGUWFUQJCDRPTL-UHFFFAOYSA-N 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 150000003873 salicylate salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 150000003890 succinate salts Chemical class 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR763790A FR1261878A (fr) | 1958-04-22 | 1958-04-22 | Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipéridinoalcoyle substituée et leur préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB875845A true GB875845A (en) | 1961-08-23 |
Family
ID=8706308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB85209D Active GB85209A (en:Method) | 1958-04-22 | ||
| GB12506/59A Expired GB875845A (en) | 1958-04-22 | 1959-04-13 | Improvements in or relating to phenthiazine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB85209D Active GB85209A (en:Method) | 1958-04-22 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3240779A (en:Method) |
| BE (1) | BE577922A (en:Method) |
| CH (4) | CH391705A (en:Method) |
| ES (1) | ES248588A1 (en:Method) |
| FR (1) | FR1261878A (en:Method) |
| GB (2) | GB875845A (en:Method) |
| LU (1) | LU36929A1 (en:Method) |
| NL (1) | NL108047C (en:Method) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453269A (en) * | 1966-01-28 | 1969-07-01 | Novo Terapeutisk Labor As | Novel chlorpromazine salts |
| EP3773597A4 (en) | 2018-04-06 | 2022-06-08 | Camp4 Therapeutics Corporation | PHENOTHIAZINE DERIVATIVES AND THEIR USES |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830987A (en) * | 1958-04-15 | Derivatives of phenthiazine | ||
| US2590125A (en) * | 1952-03-25 | Quaternary-ammonium alkyl | ||
| GB789703A (en) * | 1954-11-08 | 1958-01-29 | Rhone Poulenc Sa | New phenthiazine derivatives and processes for their preparation |
| FR1179968A (fr) * | 1956-08-01 | 1959-05-29 | Rhone Poulenc Sa | Dérivés nu-substitués de la diméthylsulfamido phénothiazine et leur procédé de préparation |
-
0
- NL NL108047D patent/NL108047C/xx active
- LU LU36929D patent/LU36929A1/xx unknown
- GB GB85209D patent/GB85209A/en active Active
- BE BE577922D patent/BE577922A/xx unknown
-
1958
- 1958-04-22 FR FR763790A patent/FR1261878A/fr not_active Expired
-
1959
- 1959-04-10 ES ES0248588A patent/ES248588A1/es not_active Expired
- 1959-04-13 GB GB12506/59A patent/GB875845A/en not_active Expired
- 1959-04-13 US US805694A patent/US3240779A/en not_active Expired - Lifetime
- 1959-04-13 CH CH1292664A patent/CH391705A/fr unknown
- 1959-04-13 CH CH1292864A patent/CH391706A/fr unknown
- 1959-04-13 CH CH1292764A patent/CH392512A/fr unknown
- 1959-04-13 CH CH7194659A patent/CH385209A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH391706A (fr) | 1965-05-15 |
| GB85209A (en:Method) | |
| NL108047C (en:Method) | |
| US3240779A (en) | 1966-03-15 |
| LU36929A1 (en:Method) | |
| CH385209A (fr) | 1964-12-15 |
| CH391705A (fr) | 1965-05-15 |
| BE577922A (en:Method) | |
| CH392512A (fr) | 1965-05-31 |
| FR1261878A (fr) | 1961-05-26 |
| ES248588A1 (es) | 1959-08-01 |
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