GB870387A - Steroid compounds and the preparation thereof - Google Patents
Steroid compounds and the preparation thereofInfo
- Publication number
- GB870387A GB870387A GB19683/59A GB1968359A GB870387A GB 870387 A GB870387 A GB 870387A GB 19683/59 A GB19683/59 A GB 19683/59A GB 1968359 A GB1968359 A GB 1968359A GB 870387 A GB870387 A GB 870387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- hydroxyl
- methyl
- fluorine
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises a compound having the formula (including the D 1, D 6 and D 16 analogues thereof): <FORM:0870387/IV (b)/1> wherein R1 is hydrogen or methyl, R2 is hydrogen, fluorine or methyl, R3 is hydrogen or hydroxyl, R4 is hydrogen, fluorine, methyl, methylene, hydroxyl or acylated hydroxyl, the acyl group containing only carbon, hydrogen and oxygen and being derived from a mono or dicarboxylic acid containing up to 10 carbon atoms, at least three of R1, R2, R3 and R4 always being hydrogen, X is hydrogen, a -halogen, a -methoxy, or a -ethoxy and Y is keto or b -hydroxyl, and a process for preparing compound having the Formula I (including the D 1, D 6 and D 16 analogues thereof) which comprises reacting with diazomethane in the presence of solvent the corresponding 21-aldehyde in anhydrous or monohydrate form. The reaction may be effected in an inert solvent at 0-25 DEG C. Illustrative products of the invention are 17b -(a ,b -oxido-propanoyl) -D 4-androstene11b -17a -diol-3-one, the corresponding D 14 and D 146- compounds and the 9-fluoro and 9-bromo derivatives thereof. Specifications 870,388, 870,389 and 870,390 are referred to.ALSO:Pharmaceutical compositions comprise, in admixture with a pharmaceutically acceptable carrier, a compound of the formula <FORM:0870387/VI/1> (or a D 1-, D 6- or D 1,6-analogue thereof), wherein R1 is hydrogen or methyl, R2 is hydrogen, fluorine or methyl, R3 is hydrogen or hydroxyl, R4 is hydrogen, fluorine, methyl, methylene, hydroxyl or acylated hydroxyl, the acyl group containing only carbon, hydrogen and oxygen and being derived from a mono or dicarboxylic acid containing up to 10 carbon atoms, at least three of R1, R2, R3 and R4 always being hydrogen, X is hydrogen, a -halogen, a -methoxy or a -ethoxy, and Y is keto or b -hydroxyl. The compositions may be in the form of tablets, aqueous suspensions, elixirs, ointments and salves. Specifications 870,388, 870,389 and 870,390 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US870387XA | 1958-06-09 | 1958-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB870387A true GB870387A (en) | 1961-06-14 |
Family
ID=22202757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19683/59A Expired GB870387A (en) | 1958-06-09 | 1959-06-09 | Steroid compounds and the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB870387A (en) |
-
1959
- 1959-06-09 GB GB19683/59A patent/GB870387A/en not_active Expired
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