GB867880A - N-acyl derivatives of (3:5-diamino-2:4:6-triiodobenzoyl)-amino acids and x-ray contrast media containing the same - Google Patents
N-acyl derivatives of (3:5-diamino-2:4:6-triiodobenzoyl)-amino acids and x-ray contrast media containing the sameInfo
- Publication number
- GB867880A GB867880A GB367858A GB367858A GB867880A GB 867880 A GB867880 A GB 867880A GB 367858 A GB367858 A GB 367858A GB 367858 A GB367858 A GB 367858A GB 867880 A GB867880 A GB 867880A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- compounds
- acetylamino
- acid
- tri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940039231 contrast media Drugs 0.000 title abstract 3
- 239000002872 contrast media Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 8
- -1 polymethylene group Chemical group 0.000 abstract 6
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 abstract 5
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- VPGHVKMBMPDAJD-UHFFFAOYSA-N 2,3-dinitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=CC(C(Cl)=O)=C1[N+]([O-])=O VPGHVKMBMPDAJD-UHFFFAOYSA-N 0.000 abstract 1
- QZRGKCOWNLSUDK-UHFFFAOYSA-N Iodochlorine Chemical compound ICl QZRGKCOWNLSUDK-UHFFFAOYSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- 238000003436 Schotten-Baumann reaction Methods 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- XZUAPPXGIFNDRA-UHFFFAOYSA-N ethane-1,2-diamine;hydrate Chemical compound O.NCCN XZUAPPXGIFNDRA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH21689A DE1125587B (de) | 1957-03-06 | 1957-03-06 | Roentgenkontrastmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB867880A true GB867880A (en) | 1961-05-10 |
Family
ID=7429122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB367858A Expired GB867880A (en) | 1957-03-06 | 1958-02-04 | N-acyl derivatives of (3:5-diamino-2:4:6-triiodobenzoyl)-amino acids and x-ray contrast media containing the same |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE564991A (en:Method) |
| DE (1) | DE1125587B (en:Method) |
| FR (1) | FR1282518A (en:Method) |
| GB (1) | GB867880A (en:Method) |
| NL (1) | NL104758C (en:Method) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953501A (en) * | 1972-02-16 | 1976-04-27 | Schering Aktiengesellschaft | Triiodoisophthalic acid monoamino acid amides |
| US4607123A (en) * | 1984-02-29 | 1986-08-19 | Dr. Franz Kohler Chemie Gmbh | Water soluble 3,5-diacetamido-2,4,6-triiodobenzoic acid derivatives |
| EP0810858A4 (en) * | 1994-12-27 | 2000-11-15 | Du Pont Pharm Co | BORONIC ACID AND ITS ESTER AS THROMBINE INHIBITORS |
| JP2009521467A (ja) * | 2005-12-23 | 2009-06-04 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
| WO2024093387A1 (zh) * | 2022-11-01 | 2024-05-10 | 科睿驰（深圳）医疗科技发展有限公司 | 显影化合物及其制备方法、显影栓塞材料及其制备方法 |
-
1957
- 1957-03-06 DE DESCH21689A patent/DE1125587B/de active Pending
-
1958
- 1958-02-04 GB GB367858A patent/GB867880A/en not_active Expired
- 1958-02-04 NL NL224625A patent/NL104758C/xx active
- 1958-02-17 FR FR758437A patent/FR1282518A/fr not_active Expired
- 1958-02-20 BE BE564991D patent/BE564991A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953501A (en) * | 1972-02-16 | 1976-04-27 | Schering Aktiengesellschaft | Triiodoisophthalic acid monoamino acid amides |
| US4607123A (en) * | 1984-02-29 | 1986-08-19 | Dr. Franz Kohler Chemie Gmbh | Water soluble 3,5-diacetamido-2,4,6-triiodobenzoic acid derivatives |
| EP0810858A4 (en) * | 1994-12-27 | 2000-11-15 | Du Pont Pharm Co | BORONIC ACID AND ITS ESTER AS THROMBINE INHIBITORS |
| JP2009521467A (ja) * | 2005-12-23 | 2009-06-04 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
| WO2024093387A1 (zh) * | 2022-11-01 | 2024-05-10 | 科睿驰（深圳）医疗科技发展有限公司 | 显影化合物及其制备方法、显影栓塞材料及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BE564991A (en:Method) | 1960-07-15 |
| DE1125587B (de) | 1962-03-15 |
| NL104758C (en:Method) | 1963-05-15 |
| FR1282518A (fr) | 1962-01-27 |
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