GB864710A - Improvements in or relating to therapeutic compositions and the manufacture thereof - Google Patents

Improvements in or relating to therapeutic compositions and the manufacture thereof

Info

Publication number
GB864710A
GB864710A GB34935/57A GB3493557A GB864710A GB 864710 A GB864710 A GB 864710A GB 34935/57 A GB34935/57 A GB 34935/57A GB 3493557 A GB3493557 A GB 3493557A GB 864710 A GB864710 A GB 864710A
Authority
GB
United Kingdom
Prior art keywords
hydrocortisone
hydroxy
sodium
acids
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34935/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB864710A publication Critical patent/GB864710A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

A therapeutic composition comprises an 11-beta, 17-alpha, 21-trihydroxy pregnane-3,20 dione and an alkyl phenol-formaldehyde-ethylene oxide condensate as solubilizing agent. The composition may be made up in aqueous solution for topical application to tissues of the eye, ear, nose and throat. Specified hormones include hydrocortisone, 2-methylenehydrocortisone, D 1 - hydrocortisone, 6 - methylhydrocortisone, 6 - methyl - D 1 - hydrocortisone, 16-hydroxy - 9a - fluorohydrocortisone and 16-hydroxy - 9a - fluoro - D 1 - hydrocortisone, which may be used as free alcohols or as the 21-esters or 16,21 diesters of acids such as acetic, propionic, tertiarybutylacetic, diethylacetic, acrylic, mono-, di- and trichloracetic, succinic, tricarballylic, glutaric, b ,b - dimethylglutaric, aconitic, itaconic, benzoic, phenylacetic, phenoxyacetic, furoic, cyclopentylcarboxylic, cyclohexylcarboxylic and cyclopentylpropionic acids. Additives include antibiotics (neomycin, polymyxin, penicillin, tetracycline, oxytetracycline, chlortetracycline, streptomycin, erythromycin, bacitracin, gramicidin, novobiocin and their salts), preservatives (benzyl alcohol, phenyl mercuric nitrate, benzalkonium chloride, phenylethyl alcohol, methyl and propyl parabens, thiomersal, and p - chloro - phenyl - a - glycerol other) buffers (e.g. sodium citrate) and other drugs (phenylephrine hydrochloride, sodium sulphacetamide, chlorpropenpyridamine gluconate, thonzylamine hydrochloride and sodium propionate). Specification 594,745 is referred to.
GB34935/57A 1956-12-24 1957-11-08 Improvements in or relating to therapeutic compositions and the manufacture thereof Expired GB864710A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US864710XA 1956-12-24 1956-12-24

Publications (1)

Publication Number Publication Date
GB864710A true GB864710A (en) 1961-04-06

Family

ID=22198775

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34935/57A Expired GB864710A (en) 1956-12-24 1957-11-08 Improvements in or relating to therapeutic compositions and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB864710A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2567041C2 (en) * 2009-11-27 2015-10-27 Джованни БАРКО PHARMACEUTICAL COMPOSITIONS AND THERAPEUTICAL APPLICATION OF HYDROCORTISONE DERIVATIVES, DESIGNATED AS Deina

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2567041C2 (en) * 2009-11-27 2015-10-27 Джованни БАРКО PHARMACEUTICAL COMPOSITIONS AND THERAPEUTICAL APPLICATION OF HYDROCORTISONE DERIVATIVES, DESIGNATED AS Deina

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