GB861379A - Therapeutic compositions comprising 1:2-benzisothiazolone derivatives - Google Patents

Therapeutic compositions comprising 1:2-benzisothiazolone derivatives

Info

Publication number
GB861379A
GB861379A GB822758A GB822758A GB861379A GB 861379 A GB861379 A GB 861379A GB 822758 A GB822758 A GB 822758A GB 822758 A GB822758 A GB 822758A GB 861379 A GB861379 A GB 861379A
Authority
GB
United Kingdom
Prior art keywords
benzisothiazolone
agents
bland
hydrogen
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB822758A
Inventor
John Selwyn Morley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB822758A priority Critical patent/GB861379A/en
Publication of GB861379A publication Critical patent/GB861379A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/408—Virucides, spermicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Solid, semi-solid and bland, high-boiling, substantially non-aqueous fluid pharmaceutical and veterinary compositions for the local treatment and/or prophylaxis of bacterial and/or fungal infections comprise non-toxic, pharmaceutical excipients and one or more 1 : 2-benzisothiazolone derivatives of general formula <FORM:0861379/VI/1> wherein R represents a hydrogen atom, an alkyl radical having not more than 3 carbon atoms, the benzyl, phenyl, or nitrophenyl radical, and R represents hydrogen; or, R is hydrogen and R1 is chlorine. Specific examples of such compounds given are: 2-benzyl-1 : 2-benzisothiazolone, 2 - methyl - 1 : 2 - benzisothiazolone and 5-chloro-1 : 2-benzisothiazolone. The compositions may be in known pharmaceutical forms suitable for local application: e.g. gels, creams, gauzes which may be shaped, e.g., into tampons, powders, e.g. for insufflation, pessaries, suppositories, solution tablets, solutions and suspensions in non-aqueous media. Numerous examples of suitable excipients are given including gelling agents, humectants, buffers, bland fluids, e.g. mineral and vegetable oils, waxes and greases, emulsifying, surface-active, disintegrating and effervescing agents, lubricants, binders and diluents. The proportion of active ingredient may be from 0.005 to 50% by weight, the range 0.005 to 10% being generally preferred. Other agents of known p therapeutic activity may be present, in particular anti-protozoal agents, other known antibacterial and/or fungicidal agents.
GB822758A 1958-03-14 1958-03-14 Therapeutic compositions comprising 1:2-benzisothiazolone derivatives Expired GB861379A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB822758A GB861379A (en) 1958-03-14 1958-03-14 Therapeutic compositions comprising 1:2-benzisothiazolone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB822758A GB861379A (en) 1958-03-14 1958-03-14 Therapeutic compositions comprising 1:2-benzisothiazolone derivatives

Publications (1)

Publication Number Publication Date
GB861379A true GB861379A (en) 1961-02-22

Family

ID=9848399

Family Applications (1)

Application Number Title Priority Date Filing Date
GB822758A Expired GB861379A (en) 1958-03-14 1958-03-14 Therapeutic compositions comprising 1:2-benzisothiazolone derivatives

Country Status (1)

Country Link
GB (1) GB861379A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315927A1 (en) * 1975-07-03 1977-01-28 Prephar SPERMICIDE COMPOSITION FOR VAGINAL APPLICATION
FR2404399A1 (en) * 1977-09-30 1979-04-27 Ici Ltd BIOCIDAL COMPOSITION CONSISTING OF A SOLUTION OF A SALT OF 1-2-BENZISOTHIAZOLINE-3-ONE
US5328926A (en) * 1991-11-07 1994-07-12 Buckman Laboratories International, Inc. Synergistic combinations of iodopropargyl compounds with 1,2-benzisothiazolin-3-one in controlling fungal and bacterial growth in aqueous fluids
US5373016A (en) * 1993-05-28 1994-12-13 Zeneca, Inc. Protection of isothiazolinone biocides from free radicals
EP2110018A1 (en) * 2006-12-13 2009-10-21 Unicharm Corporation Antibacterial sheet and absorbent article
CN102283213A (en) * 2005-10-04 2011-12-21 罗门哈斯公司 Microbicidal composition
CN105828637A (en) * 2013-12-30 2016-08-03 陶氏环球技术有限责任公司 Microbicidal Composition
US20180092908A1 (en) * 2015-01-20 2018-04-05 The Trustees Of Columbia University In The City Of New York Small molecule oxidizers of pdi and their use

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315927A1 (en) * 1975-07-03 1977-01-28 Prephar SPERMICIDE COMPOSITION FOR VAGINAL APPLICATION
FR2404399A1 (en) * 1977-09-30 1979-04-27 Ici Ltd BIOCIDAL COMPOSITION CONSISTING OF A SOLUTION OF A SALT OF 1-2-BENZISOTHIAZOLINE-3-ONE
US5328926A (en) * 1991-11-07 1994-07-12 Buckman Laboratories International, Inc. Synergistic combinations of iodopropargyl compounds with 1,2-benzisothiazolin-3-one in controlling fungal and bacterial growth in aqueous fluids
US5373016A (en) * 1993-05-28 1994-12-13 Zeneca, Inc. Protection of isothiazolinone biocides from free radicals
CN102283213B (en) * 2005-10-04 2014-05-07 罗门哈斯公司 Microbicidal composition
CN102283213A (en) * 2005-10-04 2011-12-21 罗门哈斯公司 Microbicidal composition
CN102293206A (en) * 2005-10-04 2011-12-28 罗门哈斯公司 Synergistic microbicidal compositions
US8476483B2 (en) 2006-12-13 2013-07-02 Unicharm Corporation Antibacterial sheet and absorbent article
EP2110018A4 (en) * 2006-12-13 2012-09-19 Unicharm Corp Antibacterial sheet and absorbent article
EP2110018A1 (en) * 2006-12-13 2009-10-21 Unicharm Corporation Antibacterial sheet and absorbent article
CN105828637A (en) * 2013-12-30 2016-08-03 陶氏环球技术有限责任公司 Microbicidal Composition
US20160324164A1 (en) * 2013-12-30 2016-11-10 Dow Global Technologies Llc Microbicidal composition
JP2017504597A (en) * 2013-12-30 2017-02-09 ダウ グローバル テクノロジーズ エルエルシー Bactericidal composition
US10212946B2 (en) * 2013-12-30 2019-02-26 Dow Global Technologies Llc Microbicidal composition
CN105828637B (en) * 2013-12-30 2020-03-24 陶氏环球技术有限责任公司 Microbicidal composition
US20180092908A1 (en) * 2015-01-20 2018-04-05 The Trustees Of Columbia University In The City Of New York Small molecule oxidizers of pdi and their use

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