GB847701A - Basic thio-ethers and their preparation - Google Patents
Basic thio-ethers and their preparationInfo
- Publication number
- GB847701A GB847701A GB738358A GB738358A GB847701A GB 847701 A GB847701 A GB 847701A GB 738358 A GB738358 A GB 738358A GB 738358 A GB738358 A GB 738358A GB 847701 A GB847701 A GB 847701A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- general formula
- oxide
- acid addition
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula: <FORM:0847701/IV(b)/1> and their acid addition salts (wherein R is an unsubstituted or substituted pyridine-N-oxide or quinoline-N-oxide group attached to the sulphur atom in the 2-position, wherein the substituents are halogen atoms, or alkyl or alkoxy groups containing no more than three carbon atoms and are attached to carbon atoms, R1 is a hydrogen atom or an alkyl group containing not more than twelve carbon atoms, each R2 is a hydrogen atom or an alkyl group containing not more than four carbon atoms and n is two or three), and the preparation thereof by reacting a compound of the general formula: RX or its acid addition salt (wherein X is a halogen atom in the 2-position) with a compound of the general formula: <FORM:0847701/IV(b)/2> Compounds of the general formula RX may be prepared by oxidising and halogenating the corresponding 2-amino compounds.ALSO:Therapeutic compositions comprise compounds of the general formula: <FORM:0847701/VI/1> and their acid addition salts (wherein R is an unsubstituted or-substituted pyridine-N-oxide or quinoline-N-oxide group attached to the sulphur atom in the 2-position, wherein the substituents are halogen atoms, or alkyl or alkoxy groups containing not more than three carbon atoms and are attached to carbon atoms, R1 is a hydrogen atom or an alkyl group containing not more than twelve carbon atoms, each R2 is a hydrogen atom or an alkyl group containing not more than four carbon atoms and n is two or three) in admixture with pharmaceutical carriers. Compositions containing at least 0,1-95,0% by weight of an above compound as the principal active ingredient are useful. They may be applied as ointments, powders, emulsions or suspensions. Suitable extending agents may be hydrophilic (e.g. condensation products of ethylene and propylene oxide with ethylene and propylene glycol), hydrophobic (e.g. petrolatum and other hydrocarbon greases), lactose or sorbitol, or carboxyethylcellulose and alginic acid derivatives. The compositions are useful in the treatment of superficial mycoses. Suitable acid addition salts are the bromide, chloride, iodide, sulphate, phosphate, citrate, gluconate and tartrate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64749757A | 1957-03-21 | 1957-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB847701A true GB847701A (en) | 1960-09-14 |
Family
ID=24597215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB738358A Expired GB847701A (en) | 1957-03-21 | 1958-03-07 | Basic thio-ethers and their preparation |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE565868A (en) |
DE (1) | DE1136708B (en) |
GB (1) | GB847701A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4504667A (en) * | 1983-06-24 | 1985-03-12 | Olin Corporation | Process for oxidizing halopyridines to halopyridine-N-oxides |
US4585871A (en) * | 1982-03-26 | 1986-04-29 | Olin Corporation | Process for oxidizing halopyridines to halopyridine-N-oxides |
EP0196943A1 (en) * | 1985-03-04 | 1986-10-08 | Roussel-Uclaf | 8-Thiotetrahydroquinoleine derivatives and their salts |
WO2020201096A1 (en) | 2019-03-29 | 2020-10-08 | Université de Paris | Imidazoline derivatives as cxcr4 modulators |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3048488A (en) * | 1959-11-30 | 1962-08-07 | F & M Shaefer Brewing Company | Synthetic organic chemical preservative for beer |
-
0
- BE BE565868D patent/BE565868A/xx unknown
-
1958
- 1958-03-07 GB GB738358A patent/GB847701A/en not_active Expired
- 1958-03-21 DE DE1958P0020368 patent/DE1136708B/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4585871A (en) * | 1982-03-26 | 1986-04-29 | Olin Corporation | Process for oxidizing halopyridines to halopyridine-N-oxides |
US4504667A (en) * | 1983-06-24 | 1985-03-12 | Olin Corporation | Process for oxidizing halopyridines to halopyridine-N-oxides |
EP0196943A1 (en) * | 1985-03-04 | 1986-10-08 | Roussel-Uclaf | 8-Thiotetrahydroquinoleine derivatives and their salts |
WO2020201096A1 (en) | 2019-03-29 | 2020-10-08 | Université de Paris | Imidazoline derivatives as cxcr4 modulators |
Also Published As
Publication number | Publication date |
---|---|
DE1136708B (en) | 1962-09-20 |
BE565868A (en) |
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