GB841701A - 4:4-diaminodiphenylsulphoxide derivatives - Google Patents
4:4-diaminodiphenylsulphoxide derivativesInfo
- Publication number
- GB841701A GB841701A GB1115557A GB1115557A GB841701A GB 841701 A GB841701 A GB 841701A GB 1115557 A GB1115557 A GB 1115557A GB 1115557 A GB1115557 A GB 1115557A GB 841701 A GB841701 A GB 841701A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- bis
- acid group
- carboxylic acid
- sulphoxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0841701/IV(b)/1> wherein R and R1 stand for hydrogen, a hydrocarbon radical having at least one sulphonic or carboxylic acid group, an acyl radical having at least one carboxylic acid group, or a glucose residue having a sulphonic acid group, provided that when R stands for hydrogen R1 does not stand for hydrogen or the b -carboxypropionyl radical, and salts of these compounds. The compounds may be used in the treatment of leprosy. Compounds in which R and/or R1 is a -sulphoethyl, a ,b -disulpho-g -phenyl-n-propyl, carboxymethyl, b -carboxypropionyl, or 1-sulphoglucosyl, are mentioned. 4,41-diaminodiphenyl-sulphoxide may be reacted with an aliphatic or aromatic saturated or unsaturated aldehyde in the presence of sulphurous acid or an alkali metal bisulphite or metabisulphite to form compounds in which R and/or R1 is a hydrocarbon radical having a sulphonic acid group. The aldehyde may be acetaldehyde, cinnamaldehyde, or glucose. To obtain a compound in which R and/or R1 is a hydrocarbon radical bearing a carboxylic acid group, 4,41-diamino-diphenylsulphoxide may be reacted with a halogeno-alkane carboxylic acid such as monochloracetic acid. Compounds in which R and/or R1 is an acyl radical bearing a carboxylic acid group may be obtained by reacting 4,41-diaminodiphenylsulphoxide with the anhydride of a dicarboxylic acid e.g. succinic anhydride. The compounds may be used in the form of their alkali metal salts e.g. the sodium and potassium salts. Examples describe the preparation of the disodium salt of 4.41-bis-glucosyl-aminodiphenylsulphoxide-a , a 1-disulphonic acid, disodium 4,41-bis-ethylaminodiphenylsulphoxide-a , a 1-disulphonate, 4-carboxymethylamino - 41 - aminodiphenylsulphoxide, disodium 4-amino-41-g -phenyl-n-propylaminodiphenylsulphoxide-a -b -disulphonate, the potassium salt of 4,41-bis-g -phenyl-n-propylaminodi-phenyl - sulphoxide - a b , a 1b 1 - tetrasulphonic acid, and 4,41-bis-(b -carboxypropionylamino)-diphenyl-sulphoxide. Di-sodium 4,41-bis-sulphinomethylamino-diphenyl sulphoxide tetrahydrate is described in the Provisional Specification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1115557A GB841701A (en) | 1957-04-05 | 1957-04-05 | 4:4-diaminodiphenylsulphoxide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1115557A GB841701A (en) | 1957-04-05 | 1957-04-05 | 4:4-diaminodiphenylsulphoxide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB841701A true GB841701A (en) | 1960-07-20 |
Family
ID=9981035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1115557A Expired GB841701A (en) | 1957-04-05 | 1957-04-05 | 4:4-diaminodiphenylsulphoxide derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB841701A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0083204A2 (en) * | 1981-12-28 | 1983-07-06 | Ono Pharmaceutical Co., Ltd. | 2-Aminophenol derivatives and process for their preparation |
| EP0102476A1 (en) * | 1982-08-06 | 1984-03-14 | American Cyanamid Company | Method of modulating the immune response system in mammals |
-
1957
- 1957-04-05 GB GB1115557A patent/GB841701A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0083204A2 (en) * | 1981-12-28 | 1983-07-06 | Ono Pharmaceutical Co., Ltd. | 2-Aminophenol derivatives and process for their preparation |
| EP0083204A3 (en) * | 1981-12-28 | 1983-08-24 | Ono Pharmaceutical Co., Ltd. | 2-aminophenol derivatives and process for their preparation |
| EP0102476A1 (en) * | 1982-08-06 | 1984-03-14 | American Cyanamid Company | Method of modulating the immune response system in mammals |
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