GB837465A - Self-propelling, powder-dispensing compositions - Google Patents

Self-propelling, powder-dispensing compositions

Info

Publication number
GB837465A
GB837465A GB264458A GB264458A GB837465A GB 837465 A GB837465 A GB 837465A GB 264458 A GB264458 A GB 264458A GB 264458 A GB264458 A GB 264458A GB 837465 A GB837465 A GB 837465A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
propellant
preferably
less
powder
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB264458A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06Aerosols
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; MISCELLANEOUS COMPOSITIONS; MISCELLANEOUS APPLICATIONS OF MATERIALS
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00Materials not provided for elsewhere
    • C09K3/30Materials not provided for elsewhere for aerosols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00Detergent materials characterised by their shape or physical properties
    • C11D17/0043For use with aerosol devices
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/805Adrenocorticotropic hormone or derivatives

Abstract

A self-propelling composition capable of dispensing a powder in aerosol form comprises a finely divided powder suspended in a mixture of a liquefied propellant having a b.p. less than 65 DEG F. at atmospheric pressure and a liquid non-ionic surface-active agent. The powder should have a substantially uniform particle size not greater than 100 microns, preferably less than 25 microns, constitute 0.01-20% by weight of the composition and desirably be insoluble in the surface-active agent-propellant mixture. Many medicines are specified as powders. Particularly for water-soluble powders the moisture content of the composition should be less than 300 parts per million by weight. The propellant is preferably a fluorinated or fluorochlorinated alkane containing not more than two carbon atoms and at least one fluorine atom, i.e. a "Freon." Other propellants are named. The surface-active agent should be preferably soluble in the propellant and constitute 0.1-20% by weight of the composition and have a hydrophile-lipophile balance (HLB) ratio of less than 10, preferably 1-5. Many surface-active agents are named, the sorbitan oleates being preferred. An anhydrous non-reactive desiccant, e.g. silica gel, may be incorporated in the composition. The specific gravity of the powder should be at least as great as the specific gravity of the propellant, and where the specific gravity of the medicinal ingredient is less than the specific gravity of the propellant an auxiliary solid (several specified) should be added. A formula is provided for the minimum amount of auxiliary solid required in such cases. The amount of auxiliary solid employed should be 1-10, preferably 1-3, times this minimum.
GB264458A 1957-01-31 1958-01-27 Self-propelling, powder-dispensing compositions Expired GB837465A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US63735357 true 1957-01-31 1957-01-31
US68001657 true 1957-08-23 1957-08-23
US3014844A US3014844A (en) 1957-01-31 1958-01-03 Self-propelling powder dispensing compositions

Publications (1)

Publication Number Publication Date
GB837465A true true GB837465A (en) 1960-06-15

Family

ID=22180422

Family Applications (1)

Application Number Title Priority Date Filing Date
GB264458A Expired GB837465A (en) 1957-01-31 1958-01-27 Self-propelling, powder-dispensing compositions

Country Status (6)

Country Link
US (1) US3014844A (en)
BE (1) BE556587A (en)
DE (1) DE1178975B (en)
FR (1) FR1228811A (en)
GB (1) GB837465A (en)
NL (2) NL224547A (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124505A (en) * 1964-03-10 Aerosol concentrates containing a sta-
FR2531972A1 (en) * 1980-03-17 1984-02-24 Riker Laboratories Inc self-propelled aerosol composition for delivery of a powder and process for its Production
WO1991004011A1 (en) * 1989-09-20 1991-04-04 Riker Laboratories, Inc. Medicinal aerosol formulations
EP0460064A1 (en) * 1989-02-23 1991-12-11 Rorer International (Holdings), Inc. Therapeutic aerosol formulations
EP0499344A2 (en) 1988-12-06 1992-08-19 Riker Laboratories, Inc. Medicinal aerosol formulations
EP0563389A1 (en) * 1991-08-21 1993-10-06 ZHIRNOV, Oleg Petrovich Pharmaceutical aerosol preparation and its use for treatment and prophylaxis of viral diseases
US5439670A (en) * 1989-11-28 1995-08-08 Riker Laboratories, Inc. Medicinal aerosol formulations
US5605674A (en) * 1988-12-06 1997-02-25 Riker Laboratories, Inc. Medicinal aerosol formulations
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US5766573A (en) * 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US5952008A (en) * 1993-06-24 1999-09-14 Ab Astra Processes for preparing compositions for inhalation
US6306440B1 (en) 1993-06-24 2001-10-23 Astrazeneca Ab Therapeutic preparation for inhalation
US6436902B1 (en) 1994-12-22 2002-08-20 Astrazeneca Ab Therapeutic preparations for inhalation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6610653B1 (en) 1994-06-23 2003-08-26 Astrazeneca Ab Therapeutic preparation for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US6743413B1 (en) 1991-12-18 2004-06-01 3M Company Suspension aerosol formulations
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US7160538B2 (en) 1990-02-03 2007-01-09 Boehringer Ingelheim Kg Suspension aerosol formulations of pharmaceutical products
US7994197B2 (en) 2007-02-11 2011-08-09 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8080236B2 (en) 2002-04-17 2011-12-20 Nektar Therapeutics Uk, Ltd Particulate materials
WO2013059409A1 (en) 2011-10-21 2013-04-25 3M Innovative Properties Company Manufacture of medicinal aerosol canisters
WO2013188609A1 (en) 2012-06-14 2013-12-19 3M Innovative Properties Company Metered dose dispensing valve
WO2014081746A1 (en) 2012-11-23 2014-05-30 3M Innovative Properties Company Metered dose dispensing valve
US9067031B2 (en) 2006-10-19 2015-06-30 3M Innovative Properties Company Metered dose valves and dispensers

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US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
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Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124505A (en) * 1964-03-10 Aerosol concentrates containing a sta-
FR2531972A1 (en) * 1980-03-17 1984-02-24 Riker Laboratories Inc self-propelled aerosol composition for delivery of a powder and process for its Production
GB2125426A (en) * 1980-03-17 1984-03-07 Riker Laboratories Inc Powder aerosol composition
EP0653204A2 (en) 1988-12-06 1995-05-17 Riker Laboratories, Inc. Medicinal aerosol formulations
US5683677A (en) * 1988-12-06 1997-11-04 Riker Laboratories, Inc. Medicinal aerosol formulations
US5681545A (en) * 1988-12-06 1997-10-28 Riker Laboratories, Inc. Medicinal aerosol formulations
EP0499344A2 (en) 1988-12-06 1992-08-19 Riker Laboratories, Inc. Medicinal aerosol formulations
US5766573A (en) * 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US6352684B1 (en) 1988-12-06 2002-03-05 Riker Laboratories Inc. CRC-free medicinal aerosol formulations of 1,1,1,2-tetrafluoroethane (134A) with polar adjuvant
US5674473A (en) * 1988-12-06 1997-10-07 Riker Laboratories, Inc. Medicinal aerosol formulations
US5605674A (en) * 1988-12-06 1997-02-25 Riker Laboratories, Inc. Medicinal aerosol formulations
US5720940A (en) * 1988-12-06 1998-02-24 Riker Laboratories, Inc. Medicinal aerosol formulations
US5695743A (en) * 1988-12-06 1997-12-09 Riker Laboratories, Inc. Medicinal aerosol formulations
EP0460064A4 (en) * 1989-02-23 1992-04-01 Rorer International (Holdings) Inc. Therapeutic aerosol formulations
EP0460064A1 (en) * 1989-02-23 1991-12-11 Rorer International (Holdings), Inc. Therapeutic aerosol formulations
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US5439670A (en) * 1989-11-28 1995-08-08 Riker Laboratories, Inc. Medicinal aerosol formulations
US7160538B2 (en) 1990-02-03 2007-01-09 Boehringer Ingelheim Kg Suspension aerosol formulations of pharmaceutical products
EP0563389A4 (en) * 1991-08-21 1993-10-20 Oleg Petrovich Zhyrnov Pharmaceutical aerosol preparation and its use for treatment and prophylaxis of viral diseases
EP0563389A1 (en) * 1991-08-21 1993-10-06 ZHIRNOV, Oleg Petrovich Pharmaceutical aerosol preparation and its use for treatment and prophylaxis of viral diseases
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US6743413B1 (en) 1991-12-18 2004-06-01 3M Company Suspension aerosol formulations
US6306440B1 (en) 1993-06-24 2001-10-23 Astrazeneca Ab Therapeutic preparation for inhalation
US6846801B1 (en) 1993-06-24 2005-01-25 Astrazeneca Ab Systemic administration of a therapeutic preparation
US5952008A (en) * 1993-06-24 1999-09-14 Ab Astra Processes for preparing compositions for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US6610653B1 (en) 1994-06-23 2003-08-26 Astrazeneca Ab Therapeutic preparation for inhalation
US5830853A (en) * 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US6436902B1 (en) 1994-12-22 2002-08-20 Astrazeneca Ab Therapeutic preparations for inhalation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US8470301B2 (en) 2002-04-17 2013-06-25 Nektar Therapeutics Particulate materials
US9616060B2 (en) 2002-04-17 2017-04-11 Nektar Therapeutics Particulate materials
US8828359B2 (en) 2002-04-17 2014-09-09 Nektar Therapeutics Particulate materials
US8080236B2 (en) 2002-04-17 2011-12-20 Nektar Therapeutics Uk, Ltd Particulate materials
US9067031B2 (en) 2006-10-19 2015-06-30 3M Innovative Properties Company Metered dose valves and dispensers
US7994197B2 (en) 2007-02-11 2011-08-09 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US8119639B2 (en) 2007-02-11 2012-02-21 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US9833451B2 (en) 2007-02-11 2017-12-05 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
WO2013059409A1 (en) 2011-10-21 2013-04-25 3M Innovative Properties Company Manufacture of medicinal aerosol canisters
US9694149B2 (en) 2011-10-21 2017-07-04 3M Innovative Properties Company Manufacture of medicinal aerosol canisters
WO2013188609A1 (en) 2012-06-14 2013-12-19 3M Innovative Properties Company Metered dose dispensing valve
WO2014081746A1 (en) 2012-11-23 2014-05-30 3M Innovative Properties Company Metered dose dispensing valve

Also Published As

Publication number Publication date Type
FR1228811A (en) 1960-09-02 grant
DE1178975B (en) 1964-10-01 application
NL106832C (en) 1963-12-16 grant
BE556587A (en) 1957-04-11 grant
US3014844A (en) 1961-12-26 grant
NL224547A (en) application

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