GB835468A - Recovery of tetracycline from solutions thereof - Google Patents
Recovery of tetracycline from solutions thereofInfo
- Publication number
- GB835468A GB835468A GB20992/57A GB2099257A GB835468A GB 835468 A GB835468 A GB 835468A GB 20992/57 A GB20992/57 A GB 20992/57A GB 2099257 A GB2099257 A GB 2099257A GB 835468 A GB835468 A GB 835468A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- tetracycline
- ketone
- aqueous phase
- preferred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
Abstract
Tetracycline free base in a pure form having improved colour characteristics is recovered from solutions thereof by contacting a methyl alkyl ketone solution of the crude tetracycline with acidulated water at a pH of 1.5 to 2, separating the resulting aqueous phase containing the tetracycline from the solvent phase, adjusting the pH of the aqueous phase to pH 2 to 4 and preferably 3.5, and recovering the tetracycline by crystallization from the aqueous phase. It is preferred that the quantity of acidulated water be small and that the pH of extraction be 1.8 to 2. Specified methyl alkyl ketones are methyl isobutyl ketone p (preferred), methyl butyl ketone, methyl propyl ketone, methyl isopropyl ketone and methyl amyl ketone. A preferred methyl isobutyl ketone solution of tetracycline is that obtained by extraction from a fermentation broth in the manner described and claimed in Specification 821,310. A methyl alkyl ketone solution may be prepared by extracting at pH 1.5 the filter cake obtained by adjusting a fermentation broth to pH 7 to 8.5 and filtering. The tetracycline free base may be used therapeutically without further purification; or may be treated with butanol, 2-ethoxyethanol and hydrochloric acid to form the hydrochloride. Reference has been directed by the Comptroller to Specification 747,779.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US835468XA | 1956-07-23 | 1956-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB835468A true GB835468A (en) | 1960-05-18 |
Family
ID=22179033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20992/57A Expired GB835468A (en) | 1956-07-23 | 1957-07-03 | Recovery of tetracycline from solutions thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB835468A (en) |
-
1957
- 1957-07-03 GB GB20992/57A patent/GB835468A/en not_active Expired
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