GB831071A - Analgesic compounds - Google Patents

Analgesic compounds

Info

Publication number
GB831071A
GB831071A GB1288756A GB1288756A GB831071A GB 831071 A GB831071 A GB 831071A GB 1288756 A GB1288756 A GB 1288756A GB 1288756 A GB1288756 A GB 1288756A GB 831071 A GB831071 A GB 831071A
Authority
GB
United Kingdom
Prior art keywords
phenol
ethyl
meta
carbamate
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1288756A
Inventor
Philip Guy Marshall
Patrick Anthony Mccrea
Marguerite Vera Avelin Chapman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRITISH SCHERING Ltd
Original Assignee
BRITISH SCHERING Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRITISH SCHERING Ltd filed Critical BRITISH SCHERING Ltd
Priority to GB1288756A priority Critical patent/GB831071A/en
Priority to ES0235077A priority patent/ES235077A1/en
Publication of GB831071A publication Critical patent/GB831071A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Carbonates of phenols which are substituted with alkyl or alkoxy groups containing from one to three carbon atoms are prepared by reacting the substituted phenol with an alkali metal cyanate, e.g. sodium cyanate, and trichloroacetic acid in a solvent, e.g. carbon tetrachloride or by reacting the substituted phenol with phosgene and caustic alkali followed by treatment with ammonia. Specified carbamates are those of meta-cresol having a melting-point of 135 DEG to 137 DEG C., o- and p-cresol, 2 : 3-, 3 : 4-, 2 : 4- and 2 : 5-dimethylphenol, 2 : 3 : 4-, 2 : 3 : 5-, 2 : 4 : 5- and 3 : 4 : 5 - trimethylphenol, 2 : 3 : 4 : 5 - tetramethylphenol, meta-ethyl- and meta-n-propylphenol, ortho-, meta- and para-methoxyphenol, ortho - alkyl - phenol, 2 - n propyl-phenol, 2 - n - propyl - 3 : 5 - dimethyl - phenol, 3 - methyl - 4 - ethyl - and 3 - methyl - 4 - n - propyl - phenol, 2 - ethyl - 5 - methyl - phenol, 2 - ethyl - 3 : 5 - dimethyl - phenol, 2 - ethyl - 4:5 - dimethyl - phenol, 3 - ethyl - 5 - methylphenol, 4 - ethyl - 2:5 - dimethyl - phenol, p-isopropyl - phenol, 2 - n - propyl - 5 - methyl - phenol and a - and b -naphthol. Specification 761,817 is referred to.ALSO:A therapeutic preparation contains a carbamate of a substituted phenol, the substituent or substituents being alkyl or alkoxy groups containing from one to three carbon atoms, admixed with a non-toxic, inert non-aqueous liquid or an inert solid substance. The carbamate, examples of which are listed, may be substituted in the meta position to the carbamate residue, and may have at least one free position ortho to the carbamate residue. The preparation, which may contain from 5 to 95% carbamate, may take the form of a tablet or capsule for oral administration, or an injectable solution or dispersion. Specified nonaqueous liquids are vegetable and mineral oils, e.g. arachis and paraffin oil, and polyoxyethylene glycols, and solid substances specified are starch, lactose, acacia gum, talc and magnesium stearate. Specification 761,817 is referred to.
GB1288756A 1956-04-26 1956-04-26 Analgesic compounds Expired GB831071A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB1288756A GB831071A (en) 1956-04-26 1956-04-26 Analgesic compounds
ES0235077A ES235077A1 (en) 1956-04-26 1957-04-25 Analgesic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1288756A GB831071A (en) 1956-04-26 1956-04-26 Analgesic compounds

Publications (1)

Publication Number Publication Date
GB831071A true GB831071A (en) 1960-03-23

Family

ID=10012958

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1288756A Expired GB831071A (en) 1956-04-26 1956-04-26 Analgesic compounds

Country Status (2)

Country Link
ES (1) ES235077A1 (en)
GB (1) GB831071A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056635A (en) 1974-03-28 1977-11-01 Imperial Chemical Industries Limited 2,6-Diisopropylphenol as an anaesthetic agent
US4452817A (en) * 1974-03-28 1984-06-05 Imperial Chemical Industries Plc Anaesthetic compositions containing 2,6-diisopropylphenol
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions

Also Published As

Publication number Publication date
ES235077A1 (en) 1957-11-16

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