GB822736A - New indoles and process for their manufacture - Google Patents
New indoles and process for their manufactureInfo
- Publication number
- GB822736A GB822736A GB22294/56A GB2229456A GB822736A GB 822736 A GB822736 A GB 822736A GB 22294/56 A GB22294/56 A GB 22294/56A GB 2229456 A GB2229456 A GB 2229456A GB 822736 A GB822736 A GB 822736A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- indole
- salts
- methyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
The invention comprises indoles of the formula <FORM:0822736/IV (a)/1> where R is alkyl, substituted alkyl or aralkyl, and R1 is H, alkyl, hydroxyl or substituted hydroxyl, and salts thereof. The salts are obtained by reacting an amino-nitrile <FORM:0822736/IV (a)/2> with a suitable compound RX, where X is e.g. halogen, benzenesulphonate or p-toluenesulphonate, if desired in the presence of a solvent. The salts can be converted into the free bases from which other salts may be obtained. Examples show the production of 1-methyl-2-amino-indole, 1-benzyl-2-amino-indole, 1-carbethoxymethyl - 2 - amino - indole, 1 - ethyl - 2-amino - indole, 1 - methyl - 2 - amino - 5 - methoxyindole and 1-methyl-2-amino-5-benzyloxy-indole, from which 1-methyl-2-amino-5-hydroxyindole can be obtained by hydrogenolysis. 2-Amino-benzyl cyanides can be made by reducing the corresponding 2-nitro compounds, the preparation of 2-amino-5-methoxy-benzyl cyanide and 2-amino-5-benzyloxy-benzyl cyanide being mentioned.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH822736X | 1955-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB822736A true GB822736A (en) | 1959-10-28 |
Family
ID=4539605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB22294/56A Expired GB822736A (en) | 1955-07-18 | 1956-07-18 | New indoles and process for their manufacture |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB822736A (en) |
-
1956
- 1956-07-18 GB GB22294/56A patent/GB822736A/en not_active Expired
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