GB809189A - Improvements in and relating to piperazine compounds - Google Patents

Abstract

The invention comprises piperazines of the following general formula <FORM:0809189/IV (b)/1> wherein R is a straight-chain alkyl radical containing 10-12 carbon atoms, and X- is the anion of a non-toxic acid. The compounds of the invention may be prepared by reacting 2,5-dimethylpiperazine with two equivalents of RX (X being iodide, bromide or toluenesulphonate) to give N,N1-diR-2,5-dimethylpiperazine which is then reacted with methyl iodide, toluenesulphonate, or sulphate to give the dimethiodide, dimethyl tosylate or dimethosulphate respectively. The iodide may be converted into the chloride by treatment with silver chloride or with methanolic hydrogen chloride. Other salts may be prepared by conventional methods. Alternatively 2,5-dimethylpiperazines may be reacted with formalin and formic acid to give N,N1 - bis - methyl - 2,5 - dimethylpiperazine which is then quaternized with R.X, where X is a halide. Examples describe the preparation, by the first method, of N,N1-bis-n - decyl -, n - undecyl -, and n - dodecyl - N,N1-bis - methyl - 2,5 - dimethylpiperazinium iodides and chlorides, and of N,N1 - bis - n - dodecyl-N,N1 - bis - methyl - 2,5 - dimethylpiperazinium lactate and methanesulphonate by reaction of the chloride with sodium lactate and silver methanesulphonate respectively. Compounds of the general formula wherein R is an alkyl radical containing 8, 13 and 14 carbon atoms as well as compounds of the general formula <FORM:0809189/IV (b)/2> where R is an alkyl group containing 8 or 10-14 carbon atoms, are also disclosed.