GB795942A - New dihydrostreptomycin salt - Google Patents

New dihydrostreptomycin salt

Info

Publication number
GB795942A
GB795942A GB3746955A GB3746955A GB795942A GB 795942 A GB795942 A GB 795942A GB 3746955 A GB3746955 A GB 3746955A GB 3746955 A GB3746955 A GB 3746955A GB 795942 A GB795942 A GB 795942A
Authority
GB
United Kingdom
Prior art keywords
dihydrostreptomycin
salt
pantothenate
sulphate
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3746955A
Inventor
Remo Sannicolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Luso Farmaco dItalia SpA
Original Assignee
Istituto Luso Farmaco dItalia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Luso Farmaco dItalia SpA filed Critical Istituto Luso Farmaco dItalia SpA
Priority to GB3746955A priority Critical patent/GB795942A/en
Publication of GB795942A publication Critical patent/GB795942A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dihydrostreptomycin d-pantothenate is prepared by reacting a solution of a dihydrostreptomycin salt with a salt of d-pantothenic acid. The reaction medium is water or a water-miscible solvent such as methanol, ethanol, acetone or dioxan. The preferred dihydrostreptomycin salt is the sulphate and the preferred d-pantothenic acid salt is the calcium salt, although the barium or strontium salt may also be used. The dihydrostreptomycin salt is preferably used in a concentrated solution, i.e. ratio of dihydrostreptomycin salt to solvent is 1:2. In the examples dihydrostreptomycin sulphate is reacted with calcium d-pantothenate in (a) water and (b) aqueous methanol. In the case of (a) methanol is added to facilitate precipitation of the calcium sulphate which is filtered off. The filtrate is concentrated at a temperature not greater than 20 DEG C. so that freeze drying occurs. Dihydrostreptomycin d-pantothenate is useful in therapy for the treatment of vestibular troubles (see Group VI). Reference has been directed by the Comptroller to Specification 771,338.ALSO:A therapeutic composition comprises dihydrostreptomycin d-pantothenate (see Group IV (b)) and a pharmaceutical carrier. Reference has been directed by the Comptroller to Specification 771,338.
GB3746955A 1955-12-30 1955-12-30 New dihydrostreptomycin salt Expired GB795942A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3746955A GB795942A (en) 1955-12-30 1955-12-30 New dihydrostreptomycin salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3746955A GB795942A (en) 1955-12-30 1955-12-30 New dihydrostreptomycin salt

Publications (1)

Publication Number Publication Date
GB795942A true GB795942A (en) 1958-06-04

Family

ID=10396717

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3746955A Expired GB795942A (en) 1955-12-30 1955-12-30 New dihydrostreptomycin salt

Country Status (1)

Country Link
GB (1) GB795942A (en)

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