GB794738A - Recovery of tetracycline from fermentation broths - Google Patents

Recovery of tetracycline from fermentation broths

Info

Publication number
GB794738A
GB794738A GB15135/55A GB1513555A GB794738A GB 794738 A GB794738 A GB 794738A GB 15135/55 A GB15135/55 A GB 15135/55A GB 1513555 A GB1513555 A GB 1513555A GB 794738 A GB794738 A GB 794738A
Authority
GB
United Kingdom
Prior art keywords
tetracycline
acid
toxic
heavy metal
recovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15135/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Laboratories Ltd
Original Assignee
Bristol Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Laboratories Ltd filed Critical Bristol Laboratories Ltd
Publication of GB794738A publication Critical patent/GB794738A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Aqueous solutions of tetracycline for oral and parenteral use having a pH 3.5 to 9, and containing excess of 20 mgm./ml. tetracycline are prepared by mixing tetracycline, a non-toxic heavy metal salt, e.g. aluminium sulphate and tartaric acid or similar non-toxic sequestering agents such as citric acid, ethylene diamine, tetra-acetic acid, gluconic acid and phylic acid. Alternatively, a heavy metal salt of tetracycline may be mixed with the non-toxic sequestering agent. By heavy metal is meant any metal other than the alkali metals. Specification 770,065, [Group IV (b)], is referred to.
GB15135/55A 1954-05-26 1955-05-25 Recovery of tetracycline from fermentation broths Expired GB794738A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43238854A 1954-05-26 1954-05-26

Publications (1)

Publication Number Publication Date
GB794738A true GB794738A (en) 1958-05-07

Family

ID=23715957

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15135/55A Expired GB794738A (en) 1954-05-26 1955-05-25 Recovery of tetracycline from fermentation broths

Country Status (3)

Country Link
DE (1) DE1417312B2 (en)
ES (1) ES221596A1 (en)
GB (1) GB794738A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1381306A (en) * 1972-03-03 1975-01-22 Ici Ltd Separating bacterial cells from a liquid medium

Also Published As

Publication number Publication date
DE1417312B2 (en) 1975-08-28
DE1417312A1 (en) 1968-10-24
ES221596A1 (en) 1955-09-16

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