GB750804A - Improved process for the production of crystalline procaine penicillin - Google Patents

Improved process for the production of crystalline procaine penicillin

Info

Publication number
GB750804A
GB750804A GB1916053A GB1916053A GB750804A GB 750804 A GB750804 A GB 750804A GB 1916053 A GB1916053 A GB 1916053A GB 1916053 A GB1916053 A GB 1916053A GB 750804 A GB750804 A GB 750804A
Authority
GB
United Kingdom
Prior art keywords
penicillin
procaine
production
salt
procaine penicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1916053A
Inventor
Ronald Levin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB1916053A priority Critical patent/GB750804A/en
Publication of GB750804A publication Critical patent/GB750804A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procaine penicillin mainly in platelet form is produced by crystallizing the procaine penicillin in the presence of a water-soluble ethyl hydroxyethyl cellulose. Preferably a salt of procaine such as the hydrochloride, phosphate or acetate is reacted with a metal or amine salt of penicillin, e.g. the sodium salt, in aqueous solution in the presence of 0.05 to 1 per cent and especially 0.1 per cent (w/v) of the ethyl hydroxyethyl cellulose. The concentration of penicillin in the reaction solution should not exceed 60,000 units per mil. The crystallization may be carried out in the presence of buffers such as sodium citrate and preservatives such as phenyl mercuric nitrate and sodium metabisulphite. Specification 681,140 is referred to.
GB1916053A 1953-07-10 1953-07-10 Improved process for the production of crystalline procaine penicillin Expired GB750804A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1916053A GB750804A (en) 1953-07-10 1953-07-10 Improved process for the production of crystalline procaine penicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1916053A GB750804A (en) 1953-07-10 1953-07-10 Improved process for the production of crystalline procaine penicillin

Publications (1)

Publication Number Publication Date
GB750804A true GB750804A (en) 1956-06-20

Family

ID=10124766

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1916053A Expired GB750804A (en) 1953-07-10 1953-07-10 Improved process for the production of crystalline procaine penicillin

Country Status (1)

Country Link
GB (1) GB750804A (en)

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