GB744490A - Improved process for the production of crystalline procaine penicillin - Google Patents
Improved process for the production of crystalline procaine penicillinInfo
- Publication number
- GB744490A GB744490A GB861453A GB861453A GB744490A GB 744490 A GB744490 A GB 744490A GB 861453 A GB861453 A GB 861453A GB 861453 A GB861453 A GB 861453A GB 744490 A GB744490 A GB 744490A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- salt
- procaine
- production
- procaine penicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procaine penicillin mainly in platelet form is produced by crystallizing the procaine penicillin in the presence of a water-soluble ethyl methyl cellulose ether. Preferably a salt of procaine such as the hydrochloride, phosphate or acetate is reacted with a salt of penicillin such as an amine or metal salt, e.g. the sodium salt, in aqueous solution in the presence of 0.05 to 1 per cent and especially 0.1 per cent (w./v.) of ethyl methyl cellulose ether. The concentration of penicillin in the reaction solution should not exceed 60,000 units per mil. The crystallization may be carried out in the presence of buffers such as sodium citrate and preservatives such as phenyl mercuric nitrate or sodium metabisulphite. Specification 681,140 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB861453A GB744490A (en) | 1953-03-28 | 1953-03-28 | Improved process for the production of crystalline procaine penicillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB861453A GB744490A (en) | 1953-03-28 | 1953-03-28 | Improved process for the production of crystalline procaine penicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB744490A true GB744490A (en) | 1956-02-08 |
Family
ID=9855873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB861453A Expired GB744490A (en) | 1953-03-28 | 1953-03-28 | Improved process for the production of crystalline procaine penicillin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB744490A (en) |
-
1953
- 1953-03-28 GB GB861453A patent/GB744490A/en not_active Expired
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