GB788335A - Improvements in a process for the production of optically active glutamic acid - Google Patents

Improvements in a process for the production of optically active glutamic acid

Info

Publication number
GB788335A
GB788335A GB25626/55A GB2562655A GB788335A GB 788335 A GB788335 A GB 788335A GB 25626/55 A GB25626/55 A GB 25626/55A GB 2562655 A GB2562655 A GB 2562655A GB 788335 A GB788335 A GB 788335A
Authority
GB
United Kingdom
Prior art keywords
glutamic acid
medium
urea
corn
cephalosporium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25626/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB788335A publication Critical patent/GB788335A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L(+)-Glutamic acid is prepared by cultivating a strain of a species of Cephalosporium in a nutrient medium containing urea and a source of carbohydrate under aerobic conditions until appreciable quantities of said glutamic acid are formed in the medium. The Cephalosporium strain is preferably one of the following species: C. salmosynnematum, C. diospyri and C. acremonium. Specified carbohydrate sources are sucrose, glucose, corn syrup, molasses and potato, corn or wheat starch. The urea may be supplemented by nitrates, ammonium salts, protein hydrolysates and proteins such as wheat gluten, corn gluten meal, soybean meal, distillers' solubles and cornsteep liquor. Salts such as sodium chloride, magnesium sulphate and potassium sulphate may also be added to the nutrient medium. The urea concentration is preferably 0.1 to 5 per cent by weight of the reaction medium and the urea may be added at the beginning of or during the fermentation. The temperature is preferably maintained between 25 DEG and 32 DEG C. Aerobic conditions may be maintained by passing through 0.5 to 2.5 volumes of air per volume of medium per minute. The glutamic acid is isolated from the fermentation medium by chromatographic adsorption or by extraction with a polar solvent. Specification 776,722 is referred to.
GB25626/55A 1954-10-28 1955-09-07 Improvements in a process for the production of optically active glutamic acid Expired GB788335A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US788335XA 1954-10-28 1954-10-28

Publications (1)

Publication Number Publication Date
GB788335A true GB788335A (en) 1957-12-23

Family

ID=22146483

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25626/55A Expired GB788335A (en) 1954-10-28 1955-09-07 Improvements in a process for the production of optically active glutamic acid

Country Status (1)

Country Link
GB (1) GB788335A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777571A1 (en) * 1998-04-21 1999-10-22 Revico Fermentative production of compounds of economic interest, especially flavors such as gamma-decalactone
US6036980A (en) * 1996-09-27 2000-03-14 Cerestar Holding B.V. Process for the production of glutamic acid and the use of protein hydrolysates in this process
US6518050B1 (en) 1998-04-21 2003-02-11 Revico Process for producing and extracting aromatic compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036980A (en) * 1996-09-27 2000-03-14 Cerestar Holding B.V. Process for the production of glutamic acid and the use of protein hydrolysates in this process
FR2777571A1 (en) * 1998-04-21 1999-10-22 Revico Fermentative production of compounds of economic interest, especially flavors such as gamma-decalactone
US6518050B1 (en) 1998-04-21 2003-02-11 Revico Process for producing and extracting aromatic compounds

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