GB779109A - A therapeutic composition containing an n-benzhydryl-n-benzyl piperazine derivative - Google Patents
A therapeutic composition containing an n-benzhydryl-n-benzyl piperazine derivativeInfo
- Publication number
- GB779109A GB779109A GB32171/55A GB3217155A GB779109A GB 779109 A GB779109 A GB 779109A GB 32171/55 A GB32171/55 A GB 32171/55A GB 3217155 A GB3217155 A GB 3217155A GB 779109 A GB779109 A GB 779109A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperazine
- hydrogen
- derivative
- piperazine derivative
- pyridoxine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Piperazine derivatives of the formula <FORM:0779109/IV(b)/1> where X is hydrogen or halogen, e.g. chlorine, and Y is hydrogen or lower alkyl (C1 to C6) group e.g. meta-methyl, are prepared by alkylation of piperazine under reductive conditions with a benzophenone derivative and a benzyl halide in either order, and admixed with pyridoxin in therapeutic compositions.ALSO:A therapeutic composition comprises pyridoxine with a piperazine derivative of formula: <FORM:0779109/VI/1> where X is hydrogen or halide, and Y is hydrogen or a lower alkyl (C1 to C6) group. The piperazine derivative may be used in the form of a water soluble salt e.g. dihydrochloride or dihydrobromide; or a salt of a non-toxic organic acid, e.g. citric, tartaric, acetic, succinic, maleic, glycolic, gluconic, glutaric or saccharic acid. The pyridoxin may be used as the hydrochloride or as a water soluble salt e.g. citrate, tartrate or acetate. The composition contains from one quarter to two parts by weight of the piperazine derivative, to one part by weight of pyridoxine. The example refers to tablets containing N - (p - chlorobenzhydryl) - N1 - (meta methyl benzyl) piperazine with pyridoxine hydrochloride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US779109XA | 1954-12-28 | 1954-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB779109A true GB779109A (en) | 1957-07-17 |
Family
ID=22140741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32171/55A Expired GB779109A (en) | 1954-12-28 | 1955-11-10 | A therapeutic composition containing an n-benzhydryl-n-benzyl piperazine derivative |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB779109A (en) |
-
1955
- 1955-11-10 GB GB32171/55A patent/GB779109A/en not_active Expired
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