GB775738A - Process for the preparation of sarcosine - Google Patents
Process for the preparation of sarcosineInfo
- Publication number
- GB775738A GB775738A GB31240/55A GB3124055A GB775738A GB 775738 A GB775738 A GB 775738A GB 31240/55 A GB31240/55 A GB 31240/55A GB 3124055 A GB3124055 A GB 3124055A GB 775738 A GB775738 A GB 775738A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylamine
- salt
- alkali
- sarcosine
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sarcosine is prepared by dispersing a monohaloacetic acid or salt thereof in finely divided form (solid, liquid or solution) in methylamine at room temperature or below, preferably around 0 DEG C., using methylamine in considerable excess over the theoretical amount. The reaction is completed by standing at room temperature or by heating to 20-130 DEG C. in a pressure vessel. When anhydrous methylamine is used the temperature is preferably below -6 DEG C. Alkali may be present in the methylamine to absorb the hydrogen halide liberated, to decompose any methylamine salt of sarcosine formed and to produce the alkali salt of sarcosine if this is desired. Alternatively, the alkali may be added after the haloacetic acid salt. Examples are given of the process using chloracetic acid and its sodium salt as reactants, a minor proportion of disarcosine being obtained as by-product. Bromo-and iodo-acetic acids are also mentioned and the alkali may also be potassium hydroxide or carbonate, calcium oxide or hydroxide, pyridine, piperidine or excess methylamine. The mixing may take place as low as -70 DEG C. and is preferably carried out slowly with vigorous agitation. Batch processes are preferred to continuous operation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US775738XA | 1954-11-17 | 1954-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB775738A true GB775738A (en) | 1957-05-29 |
Family
ID=22138867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31240/55A Expired GB775738A (en) | 1954-11-17 | 1955-11-01 | Process for the preparation of sarcosine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB775738A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115322122A (en) * | 2022-09-14 | 2022-11-11 | 宁夏太康药业有限公司 | Method for preparing creatine monohydrate from creatine chelated calcium aqueous solution |
| CN115772100A (en) * | 2022-12-16 | 2023-03-10 | 山东阳谷华泰化工股份有限公司 | Method for continuously producing creatine monohydrate through micro-channel reaction device |
| CN115819259A (en) * | 2022-09-02 | 2023-03-21 | 宁夏太康药业有限公司 | Method for preparing sarcosine by chelating calcium |
-
1955
- 1955-11-01 GB GB31240/55A patent/GB775738A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115819259A (en) * | 2022-09-02 | 2023-03-21 | 宁夏太康药业有限公司 | Method for preparing sarcosine by chelating calcium |
| CN115322122A (en) * | 2022-09-14 | 2022-11-11 | 宁夏太康药业有限公司 | Method for preparing creatine monohydrate from creatine chelated calcium aqueous solution |
| CN115772100A (en) * | 2022-12-16 | 2023-03-10 | 山东阳谷华泰化工股份有限公司 | Method for continuously producing creatine monohydrate through micro-channel reaction device |
| CN115772100B (en) * | 2022-12-16 | 2024-06-11 | 山东阳谷华泰化工股份有限公司 | Method for continuously producing creatine monohydrate by micro-channel reaction device |
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