Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23291/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Publication of GB773630ApublicationCriticalpatent/GB773630A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
14-Bromocodeinone is manufactured by reacting thebaine with an N-bromoamide or an N-bromoimide, advantageously in the presence of a ketone or an aqueous solution thereof and at a temperature below 30 DEG C. (e.g. 10-20 DEG C.). In examples, thebaine is treated at 15-18 DEG C. with: (1) N-bromosuccinimide in aqueous acetone; (2) N-bromoacetamide in aqueous acetone; (3) N-bromophthalide in aqueous methyl ethyl ketone. Reference is also made to the use of N-bromopropionamide and N-bromoglutarimide, and, as solvents, diethyl, methyl n-propyl, methyl heptyl and methyl isobutyl ketones and cyclohexanone, in aqueous solution.
GB23291/55A1954-08-161955-08-12Preparation of 14-bromocodeinone
ExpiredGB773630A
(en)